High feasibility of salivary therapeutic drug monitoring in linezolid, but lower feasibility in tedizolid: a single-dose study in healthy subjects and a monocentric prospective exploratory study in patients who received linezolid

Salivary therapeutic drug monitoring (TDM) offers the potential to reduce the risks, burden, time and costs of blood-based TDM, but its feasibility for use with oxazolidinone antibiotics and the influence of food intake remain unknown. We conducted a healthy subject study with 12 healthy participant...

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Bibliographic Details
Published in:	Journal of antimicrobial chemotherapy Vol. 80; no. 8; p. 2080
Main Authors:	Kawasuji, Hitoshi, Tsuji, Yasuhiro, Miyaki, Keiko, Aoyama, Takahiko, Kurosaki, Fumihiro, Ezaki, Masayoshi, Koshiyama, Yuki, Takegoshi, Yusuke, Kaneda, Makito, Murai, Yushi, Kimoto, Kou, Nagaoka, Kentaro, Yamamoto, Yoshihiro
Format:	Journal Article
Language:	English
Published:	England 01.08.2025
Subjects:	Adult Aged Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Chromatography, High Pressure Liquid Drug Monitoring - methods Feasibility Studies Female Healthy Volunteers Humans Linezolid - administration & dosage Linezolid - pharmacokinetics Male Middle Aged Oxazolidinones - administration & dosage Oxazolidinones - pharmacokinetics Prospective Studies Saliva - chemistry Tetrazoles - administration & dosage Tetrazoles - pharmacokinetics Young Adult
ISSN:	1460-2091, 1460-2091
Online Access:	Get more information
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