The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network

N 6 -methyladenosine (m6A) is the most abundant modification in eukaryotic messenger RNAs (mRNAs), and plays important roles in many bioprocesses. However, its functions in bladder cancer (BCa) remain elusive. Here, we discovered that methyltransferase-like 3 (METTL3), a major RNA N 6 -adenosine met...

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Veröffentlicht in:	Oncogene Jg. 38; H. 19; S. 3667 - 3680
Hauptverfasser:	Cheng, Maosheng, Sheng, Lu, Gao, Qian, Xiong, Qiuchan, Zhang, Haojie, Wu, Mingqing, Liang, Yu, Zhu, Fengyu, Zhang, Yingyin, Zhang, Xiuhong, Yuan, Quan, Li, Yang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 09.05.2019 Nature Publishing Group
Schlagworte:	13/31 13/89 13/95 38/39 45/91 631/208/176 631/67/589/1336 64/60 96/63 Adenosine Apoptosis Bladder cancer Cell Biology Cell growth Cell proliferation Cell survival DNA-directed RNA polymerase Gene expression Human Genetics Internal Medicine Medicine Medicine & Public Health Myc protein N6-methyladenosine NF-κB protein Oncology Polymerase chain reaction Ribonucleic acid RNA Tumorigenicity
ISSN:	0950-9232, 1476-5594, 1476-5594
Online-Zugang:	Volltext
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