A Rare Presentation of Undiagnosed Systemic Syphilis: A Case Report and Review of Literature

Within the specialties of infectious diseases and dermatology, few rashes involve the palms and soles. The syphilitic rash has a pathognomonic association with these body surfaces and signals physicians to investigate this disease. However, the distinct presentations and symptoms associated with syp...

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Vydáno v:Curēus (Palo Alto, CA) Ročník 14; číslo 8; s. e27911
Hlavní autoři: Ruiz de Villa, Ariel, Haider, Asad A, Frimer, Leora, Lleshi, Amina, Bazikian, Yvette
Médium: Journal Article
Jazyk:angličtina
Vydáno: Palo Alto Springer Nature B.V 12.08.2022
Cureus
Témata:
Abdomen
Antibodies
Antigens
Biopsy
Blood
Brain diseases
Case reports
Cytomegalovirus
Headaches
Hepatitis
Infections
Infectious Disease
Internal Medicine
Laboratories
Migraine
Penicillin
Polymerase chain reaction
Proteins
Pruritus
Serology
Skin
Syphilis
Tumor necrosis factor-TNF
Viral infections
ISSN:2168-8184, 2168-8184
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Popis
Shrnutí:Within the specialties of infectious diseases and dermatology, few rashes involve the palms and soles. The syphilitic rash has a pathognomonic association with these body surfaces and signals physicians to investigate this disease. However, the distinct presentations and symptoms associated with syphilis and the various stages of the disease make it diagnostically challenging. We herein report a rather intricate and unusual case of a patient who presented with a new-onset headache and blurred vision and a two-month history of diffuse pruritic maculopapular rash sparing the palms and soles. Several physicians had not established a diagnosis in the outpatient setting. Inpatient workup eventually revealed that the patient was suffering from secondary syphilis with neurological and ocular involvement. Management included a prolonged course of intravenous penicillin G leading to a complete recovery. We share images of the skin findings and the details of the intricate workup and hospital course, as well as a review of the literature.
Bibliografie:ObjectType-Case Study-2
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.27911