Early evidence of beneficial and protective effects of Protectin DX treatment on behavior responses and type-1 diabetes mellitus related-parameters: A non-clinical approach

Protectin DX (PDX), a specialized pro-resolving lipid mediator, presents potential therapeutic applications across various medical conditions due to its anti-inflammatory and antioxidant properties. Since type-1 diabetes mellitus (T1DM) is a disease with an inflammatory and oxidative profile, explor...

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Bibliographic Details
Published in:	Progress in neuro-psychopharmacology & biological psychiatry Vol. 133; p. 111028
Main Authors:	Waltrick, Ana Paula Farias, Radulski, Débora Rasec, de Oliveira, Kauê Marcel, Acco, Alexandra, Verri, Waldiceu Aparecido, da Cunha, Joice Maria, Zanoveli, Janaina Menezes
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 13.07.2024
Subjects:	Animals Antioxidants - pharmacology Antioxidants - therapeutic use Anxiety Anxiety - drug therapy Anxiety - etiology Behavior, Animal - drug effects Depression Depression - drug therapy Depression - etiology Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - psychology Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - psychology Diabetic neuropathic pain Diabetic Neuropathies - drug therapy Docosahexaenoic Acids - pharmacology Docosahexaenoic Acids - therapeutic use Hippocampus - drug effects Hippocampus - metabolism Hyperalgesia - drug therapy Male Prefrontal Cortex - drug effects Rats Rats, Wistar Specialized pro-resolving mediators Streptozotocin Depression Anxiety Diabetic neuropathic pain Streptozotocin Specialized pro-resolving mediators
ISSN:	0278-5846, 1878-4216, 1878-4216
Online Access:	Get full text
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