Thyroid and islet autoantibodies predict autoimmune thyroid disease already at Type 1 diabetes diagnosis
CONTEXT: Screening of autoimmune thyroid disease in children and young adults with Type 1 diabetes is important but vary greatly between clinics. OBJECTIVE: The aim was to determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA- DQ at diagnosis of Ty...
Uloženo v:
| Vydáno v: | The journal of clinical endocrinology and metabolism Ročník 102; číslo 4; s. jc.2016-2335 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
2017
|
| Témata: | |
| ISSN: | 0021-972X, 1945-7197, 1945-7197 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | CONTEXT: Screening of autoimmune thyroid disease in children and young adults with Type 1 diabetes is important but vary greatly between clinics.
OBJECTIVE: The aim was to determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA- DQ at diagnosis of Type 1 diabetes for autoimmune thyroid disease during subsequent follow-up.
SETTING: 43 Paediatric Endocrinology units Sweden. Design, patients and main outcome measures: At diagnosis of Type 1 diabetes, samples from 2433 children were analysed for autoantibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb), glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated protein-2 (IA-2A), and the three variants of the zinc transporter 8 (ZnT8W/R/QA) as well as HLA-DQA1-B1 genotypes and thyroid function. After 5.1-9.5 years disease duration, children treated with thyroxine were identified in the Swedish National Board of Health and Welfare Prescribed Drug Register.
RESULTS: Thyroxine had been prescribed to 6% (147/2433; 66% girls). In patients below 5 years, female gender (HR=4.60, p=0.008) and GADA (HR=5.80, p=0.02) were significant predictors. In patients 5-10 years, TPOAb (HR=20.56, p<0.0001), TGAb (HR=3.40, p=0.006) and TSH outside the reference limit (HR=3.64, p<0.001) were predictors while in the 10-15 year olds, TPOAb (HR=17.00, p<0.001) and TSH outside the reference limit (HR=4.11, p<0.001) predicted future thyroxine prescription.
CONCLUSION: In addition to TPOAb and TSH, positive GADA tested at the diagnosis of type 1 diabetes is important for the prediction of autoimmune thyroid disease in children below 5 years of age. |
|---|---|
| AbstractList | CONTEXT: Screening of autoimmune thyroid disease in children and young adults with Type 1 diabetes is important but vary greatly between clinics. OBJECTIVE: The aim was to determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA- DQ at diagnosis of Type 1 diabetes for autoimmune thyroid disease during subsequent follow-up. SETTING: 43 Paediatric Endocrinology units Sweden. Design, patients and main outcome measures: At diagnosis of Type 1 diabetes, samples from 2433 children were analysed for autoantibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb), glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated protein-2 (IA-2A), and the three variants of the zinc transporter 8 (ZnT8W/R/QA) as well as HLA-DQA1-B1 genotypes and thyroid function. After 5.1-9.5 years disease duration, children treated with thyroxine were identified in the Swedish National Board of Health and Welfare Prescribed Drug Register. RESULTS: Thyroxine had been prescribed to 6% (147/2433; 66% girls). In patients below 5 years, female gender (HR=4.60, p=0.008) and GADA (HR=5.80, p=0.02) were significant predictors. In patients 5-10 years, TPOAb (HR=20.56, p<0.0001), TGAb (HR=3.40, p=0.006) and TSH outside the reference limit (HR=3.64, p<0.001) were predictors while in the 10-15 year olds, TPOAb (HR=17.00, p<0.001) and TSH outside the reference limit (HR=4.11, p<0.001) predicted future thyroxine prescription. CONCLUSION: In addition to TPOAb and TSH, positive GADA tested at the diagnosis of type 1 diabetes is important for the prediction of autoimmune thyroid disease in children below 5 years of age. CONTEXT: Screening of autoimmune thyroid disease in children and young adults with Type 1 diabetes is important but vary greatly between clinics. OBJECTIVE: The aim was to determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA- DQ at diagnosis of Type 1 diabetes for autoimmune thyroid disease during subsequent follow-up. SETTING: 43 Paediatric Endocrinology units Sweden. Design, patients and main outcome measures: At diagnosis of Type 1 diabetes, samples from 2433 children were analysed for autoantibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb), glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated protein-2 (IA-2A), and the three variants of the zinc transporter 8 (ZnT8W/R/QA) as well as HLA-DQA1-B1 genotypes and thyroid function. After 5.1-9.5 years disease duration, children treated with thyroxine were identified in the Swedish National Board of Health and Welfare Prescribed Drug Register. RESULTS: Thyroxine had been prescribed to 6% (147/2433; 66% girls). In patients below 5 years, female gender (HR=4.60, p=0.008) and GADA (HR=5.80, p=0.02) were significant predictors. In patients 5-10 years, TPOAb (HR=20.56, p<0.0001), TGAb (HR=3.40, p=0.006) and TSH outside the reference limit (HR=3.64, p<0.001) were predictors while in the 10-15 year olds, TPOAb (HR=17.00, p<0.001) and TSH outside the reference limit (HR=4.11, p<0.001) predicted future thyroxine prescription. CONCLUSION: In addition to TPOAb and TSH, positive GADA tested at the diagnosis of type 1 diabetes is important for the prediction of autoimmune thyroid disease in children below 5 years of age. |
| Author | Jonsdottir, Berglind Larsson, Christer Marcus, Claude Ludvigsson, Johnny Forsander, Gun Elding Larsson, Helena Samuelsson, Ulf Carlsson, Annelie Lernmark, Åke Ivarsson, Sten Anders Örtqvist, Eva |
| Author_xml | – sequence: 1 givenname: Berglind surname: Jonsdottir fullname: Jonsdottir, Berglind – sequence: 2 givenname: Christer surname: Larsson fullname: Larsson, Christer – sequence: 3 givenname: Annelie surname: Carlsson fullname: Carlsson, Annelie – sequence: 4 givenname: Gun surname: Forsander fullname: Forsander, Gun – sequence: 5 givenname: Sten Anders surname: Ivarsson fullname: Ivarsson, Sten Anders – sequence: 6 givenname: Åke surname: Lernmark fullname: Lernmark, Åke – sequence: 7 givenname: Johnny surname: Ludvigsson fullname: Ludvigsson, Johnny – sequence: 8 givenname: Claude surname: Marcus fullname: Marcus, Claude – sequence: 9 givenname: Ulf surname: Samuelsson fullname: Samuelsson, Ulf – sequence: 10 givenname: Eva surname: Örtqvist fullname: Örtqvist, Eva – sequence: 11 givenname: Helena surname: Elding Larsson fullname: Elding Larsson, Helena |
| BackLink | https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-134863$$DView record from Swedish Publication Index (Linköpings universitet) |
| BookMark | eNp1UU1v1DAQtVCR2H7c-AH5AaT4K3FyrAoUpEpclqq30cQed73KxpHtCO2_J8uWC4LTjGbem_dG75JdTHEixt4Lfiuk4B_39lZy0dZSqeYN24heN7URvblgG86lqHsjn9-xy5z3nAutG7Vhu-3umGJwFU6uCnmkUuFSIk4lDNEFytWcyAV7HofDYZmoKq8cFzJhpgrHROiOFZZqe5ypEusGByore21epphDvmZvPY6Zbl7rFfvx5fP2_mv9-P3h2_3dY22l0bqmnjuU2HrPfedb33XKtJYL0xqPDeeO1OAalK1q-sH21hhqtEdNtP7jUKkrhue7-SfNywBzCgdMR4gYYI6p4AiJVtvJ7mBcIBOsqDFYLCFOGWTvJJnOgfCWg-atBHTkQOnGE2rTCqNXjfq_Gp_C0x3E9AJjWEAo3bUnT_KMtynmnMiDDeW3YEkYRhAcTvnB3sIpPzjlt5I-_EX6I_NP-C-i_KJW |
| CitedBy_id | crossref_primary_10_1155_2018_1856137 crossref_primary_10_3389_fimmu_2020_01922 crossref_primary_10_1007_s12016_018_8709_9 crossref_primary_10_15557_PiMR_2023_0050 crossref_primary_10_3389_fendo_2020_00476 crossref_primary_10_1159_000479964 |
| ContentType | Journal Article |
| CorporateAuthor | for the BDD Study group Pediatrik, Lund Section V Institutionen för kliniska vetenskaper, Lund Profile areas and other strong research environments Lunds universitet Department of Clinical Sciences, Malmö Department of Laboratory Medicine Lund University Sektion V Institutionen för laboratoriemedicin Celiac Disease and Diabetes Unit Department of Clinical Sciences, Lund Strategiska forskningsområden (SFO) EXODIAB: Excellence of Diabetes Research in Sweden Faculty of Medicine Celiaki och diabetes Strategic research areas (SRA) Paediatrics (Lund) Medicinska fakulteten Profilområden och andra starka forskningsmiljöer Pediatrisk endokrinologi Institutionen för kliniska vetenskaper, Malmö Paediatric Endocrinology |
| CorporateAuthor_xml | – name: for the BDD Study group – name: Faculty of Medicine – name: Medicinska fakulteten – name: Strategiska forskningsområden (SFO) – name: Celiaki och diabetes – name: Department of Laboratory Medicine – name: Celiac Disease and Diabetes Unit – name: Institutionen för kliniska vetenskaper, Malmö – name: Institutionen för kliniska vetenskaper, Lund – name: Strategic research areas (SRA) – name: Lunds universitet – name: Department of Clinical Sciences, Lund – name: Profilområden och andra starka forskningsmiljöer – name: Paediatric Endocrinology – name: Paediatrics (Lund) – name: Lund University – name: EXODIAB: Excellence of Diabetes Research in Sweden – name: Institutionen för laboratoriemedicin – name: Sektion V – name: Pediatrik, Lund – name: Profile areas and other strong research environments – name: Section V – name: Pediatrisk endokrinologi – name: Department of Clinical Sciences, Malmö |
| DBID | AAYXX CITATION ADTPV AOWAS DG8 D95 |
| DOI | 10.1210/jc.2016-2335 |
| DatabaseName | CrossRef SwePub SwePub Articles SWEPUB Linköpings universitet SWEPUB Lunds universitet |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1945-7197 |
| ExternalDocumentID | oai_portal_research_lu_se_publications_29d2e78d_1fc0_4062_aded_345fea476174 oai_DiVA_org_liu_134863 10_1210_jc_2016_2335 |
| GroupedDBID | --- -~X .55 .XZ 08P 0R~ 18M 1TH 29K 2WC 34G 354 39C 4.4 48X 53G 5GY 5RS 5YH 8F7 AABZA AACZT AAIMJ AAPQZ AAPXW AARHZ AAUAY AAVAP AAWTL AAYXX ABBLC ABDFA ABEJV ABGNP ABJNI ABLJU ABMNT ABNHQ ABOCM ABPMR ABPPZ ABPQP ABPTD ABQNK ABVGC ABWST ABXVV ABXZS ACGFO ACGFS ACPRK ACUTJ ACYHN ADBBV ADGKP ADGZP ADHKW ADNBA ADQBN ADRTK ADVEK AEHZK AELWJ AEMDU AEMQT AENEX AENZO AEOTA AETBJ AEWNT AFCHL AFFZL AFGWE AFOFC AFRAH AFXAL AFYAG AGINJ AGQXC AGUTN AHMBA AHMMS AJEEA ALMA_UNASSIGNED_HOLDINGS ALXQX APIBT ARIXL ASPBG ATGXG AVWKF AZFZN BAWUL BAYMD BCRHZ BEYMZ BSWAC BTRTY C45 CDBKE CITATION CS3 D-I DAKXR DIK E3Z EBS EJD EMOBN ENERS F5P FECEO FHSFR FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 HZ~ H~9 KBUDW KOP KSI KSN L7B M5~ MHKGH MJL N9A NLBLG NOMLY NOYVH NU- NVLIB O9- OAUYM OBH OCB ODMLO OFXIZ OGEVE OHH OJZSN OK1 OPAEJ OVD OVIDX P2P P6G REU ROX ROZ TEORI TJX TLC TR2 TWZ VVN W8F WOQ X7M YBU YFH YHG YOC YSK ZY1 ~02 ~H1 .GJ 3O- 7X7 88E 8FI 8FJ AAJQQ AAKAS AAPGJ AAQQT AAUQX AAWDT AAYJJ ABDPE ABUWG ACFRR ACVCV ACZBC ADMTO ADTPV ADZCM AERZD AFFHD AFFNX AFFQV AFKRA AGKRT AGMDO AHGBF AI. AJBYB AJDVS AOWAS APJGH AQDSO AQKUS AVNTJ BENPR BPHCQ BVXVI CCPQU DG8 EIHJH FEDTE FYUFA HMCUK HVGLF IAO IHR INH ITC J5H M1P MBLQV N4W OBFPC PHGZM PHGZT PJZUB PPXIY PQQKQ PROAC PSQYO TMA UKHRP VH1 WHG X52 ZGI ZXP D95 |
| ID | FETCH-LOGICAL-c2744-e90da2a6ff0f8f6f88376c01767fa500de3bd5a26359bc9c77e54fa4ee445da33 |
| ISSN | 0021-972X 1945-7197 |
| IngestDate | Thu Nov 27 03:11:42 EST 2025 Tue Nov 04 17:01:22 EST 2025 Sat Nov 29 02:29:10 EST 2025 Tue Nov 18 22:13:56 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c2744-e90da2a6ff0f8f6f88376c01767fa500de3bd5a26359bc9c77e54fa4ee445da33 |
| ParticipantIDs | swepub_primary_oai_portal_research_lu_se_publications_29d2e78d_1fc0_4062_aded_345fea476174 swepub_primary_oai_DiVA_org_liu_134863 crossref_citationtrail_10_1210_jc_2016_2335 crossref_primary_10_1210_jc_2016_2335 |
| PublicationCentury | 2000 |
| PublicationDate | 2017 |
| PublicationDateYYYYMMDD | 2017-01-01 |
| PublicationDate_xml | – year: 2017 text: 2017 |
| PublicationDecade | 2010 |
| PublicationTitle | The journal of clinical endocrinology and metabolism |
| PublicationYear | 2017 |
| SSID | ssj0014453 |
| Score | 2.2055185 |
| Snippet | CONTEXT: Screening of autoimmune thyroid disease in children and young adults with Type 1 diabetes is important but vary greatly between clinics.
OBJECTIVE:... CONTEXT: Screening of autoimmune thyroid disease in children and young adults with Type 1 diabetes is important but vary greatly between clinics. OBJECTIVE:... |
| SourceID | swepub crossref |
| SourceType | Open Access Repository Enrichment Source Index Database |
| StartPage | jc.2016-2335 |
| SubjectTerms | Clinical Medicine Endocrinology and Diabetes Endokrinologi och diabetes Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap |
| Title | Thyroid and islet autoantibodies predict autoimmune thyroid disease already at Type 1 diabetes diagnosis |
| URI | https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-134863 |
| Volume | 102 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1945-7197 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0014453 issn: 1945-7197 databaseCode: 7X7 dateStart: 20170101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1945-7197 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0014453 issn: 1945-7197 databaseCode: BENPR dateStart: 20170101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9QwFLaGKUJcEKs6bPIBuIwiZXHi-DiUVhygqlCpKi5W4qVNFZJRkqnan8S_5Dl2MjOlSOXAJRp57CTy--K3-L3PCL3TKk8iGSce9ZXwSEC0l_tUeqGMw1gmTEd9QP_kCz08TE9P2dFk8muohbksaVWlV1ds-V9FDW0gbFM6-w_iHm8KDfAbhA5XEDtc7yj466YupN0VaEsT0111NUxgkdcmZdDQAshC2ObClIcosD7tGLddMzcspZm8NpWOxlGdB-sYrbS5eUW7adYasG1wUIzllqqSNSxL1Zro6afqAHblQFxoTwtowTXuChs3UM0ZjJZjohA43u2QGWAWpHU28V7WlMN_C5OuU4wgPaibti_b6cP-q2oztmGLOMcqg8BjtD9qHfSUXZwZiT0a2Hxet-BeGBrKIPHCyLKe_KERwKU1GuFGt23i7RsKcUxTNA4SjOcXgpvR3Iy-h3ZCGrN0inY-7h8efRu3rAhxlKfuxV2VhSmR2nz6lv2zxU7bWzTHj9Ej54rghYXQEzRR1VP04KtLtniGzh2SMMwk7pGEt5GEHZLwGknYIQk7JGGHJJx12CAJB3hAEh6R9Bx9P9g_3vvsuYM5PGEIJT3FfJmFWaK1r1Od6DQFNSVAfgnV5oQNqaJcxpnhOWK5YIJSFROdEaVgkmQWRS_QtKortYswS0JfZSmoBa2JAPc79HMqIsWEonGm8hmaD9PFhWOtN4enlPw24czQ-7H30rK1_KXfBzvzYy_Dsv6pOFnwujnjZbHiQUTSJJqhH7d0tJ4xd3Rc57xc8Vbx5UacnYdMhoqmkgda-Bys5pBnUkkekVirjFBwHMjLO77tK_TQfBw28PcaTbtmpd6g--KyK9rmrcPhbwwcwIE |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Thyroid+and+islet+autoantibodies+predict+autoimmune+thyroid+disease+already+at+Type+1+diabetes+diagnosis&rft.jtitle=The+journal+of+clinical+endocrinology+and+metabolism&rft.au=Jonsdottir%2C+Berglind&rft.au=Larsson%2C+Christer&rft.au=Carlsson%2C+Annelie&rft.au=Forsander%2C+Gun&rft.date=2017&rft.issn=0021-972X&rft.eissn=1945-7197&rft.spage=jc.2016-2335&rft_id=info:doi/10.1210%2Fjc.2016-2335&rft.externalDBID=n%2Fa&rft.externalDocID=10_1210_jc_2016_2335 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-972X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-972X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-972X&client=summon |