The Noncoding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions

While the coding genome of pancreatic cancer has been characterized in detail, features of the noncoding genome remain relatively unexplored. We used whole-genome sequencing to study the coding and noncoding genomes (promoters, enhancers, and noncoding-nonenhancer regions) in two unique patient coho...

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Veröffentlicht in:	Cancer research communications Jg. 5; H. 10; S. 1839 - 1851
Hauptverfasser:	Hayashi, Akimasa, Ho, Yu-Jui, Makohon-Moore, Alvin P., Zucker, Amanda, Hong, Jungeui, Umeda, Shigeaki, Karnoub, Elias-Ramzey, Huang, Jinlong, Baez, Priscilla, Kappagantula, Rajya, Melchor, Jerry P., Park, Wungki, O’Reilly, Eileen M., Socci, Nicholas D., Oki, Shinya, Iacobuzio-Donahue, Christine A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2025
Schlagworte:	Animals Enhancer Elements, Genetic Gene Expression Regulation, Neoplastic Humans Mice Mutation Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Promoter Regions, Genetic Whole Genome Sequencing
ISSN:	2767-9764, 2767-9764
Online-Zugang:	Volltext
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