Effects of citicoline on level of consciousness, serum level of fetuin-A and matrix Gla-protein (MGP) in trauma patients with diffuse axonal injury (DAI) and GCS≤8
Citicoline, a neuroprotective drug, has been suggested to improve level of consciousness, mitigating secondary to brain damage and ectopic vascular calcification, following post-traumatic neurogenesis and angiogenesis, inducing calcification modulators, like fetuin-A and matrix Gla-protein (MGP). Th...
Gespeichert in:
| Veröffentlicht in: | Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES Jg. 20; H. 6; S. 410 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Turkey
01.11.2014
|
| Schlagworte: | |
| ISSN: | 1307-7945, 1307-7945 |
| Online-Zugang: | Weitere Angaben |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Citicoline, a neuroprotective drug, has been suggested to improve level of consciousness, mitigating secondary to brain damage and ectopic vascular calcification, following post-traumatic neurogenesis and angiogenesis, inducing calcification modulators, like fetuin-A and matrix Gla-protein (MGP). This study aimed to investigate effects of citicoline on levels of consciousness, serum levels of fetuin-A and MGP in patients with severe traumatic brain injury.
This double blind randomized controlled trial (RCT) was conducted on patients with diagnosis of diffuse axonal injury (DAI) and GCS≤8. The cases were treated with citicoline (500 mg every 6 hours) intravenously for fifteen days. Daily GCS assessment and intermittent blood sampling were done for both cases and controls.
Fifty-eight patients were included in the study and during the study period, mean GCS levels improved in both groups; however, the difference was inconsiderable (p>0.05). Serum levels of fetuin-A, a negative phase reactant, increased in the group treated with citicoline (p=0.012), while these changes were insignificant for the controls (p=0.455). Serum levels of MGP, a calcification inhibitor, increased in the cases (p=0.046). The alterations were inconsequential in the control group (p=0.405).
The findings of this study suggest neutral effects of citicoline on level of consciousness and GCS. Through increasing levels of fetuin-A and MGP, citicoline may have protective effects against inflammatory damage and vascular calcification secondary to head trauma. |
|---|---|
| AbstractList | Citicoline, a neuroprotective drug, has been suggested to improve level of consciousness, mitigating secondary to brain damage and ectopic vascular calcification, following post-traumatic neurogenesis and angiogenesis, inducing calcification modulators, like fetuin-A and matrix Gla-protein (MGP). This study aimed to investigate effects of citicoline on levels of consciousness, serum levels of fetuin-A and MGP in patients with severe traumatic brain injury.
This double blind randomized controlled trial (RCT) was conducted on patients with diagnosis of diffuse axonal injury (DAI) and GCS≤8. The cases were treated with citicoline (500 mg every 6 hours) intravenously for fifteen days. Daily GCS assessment and intermittent blood sampling were done for both cases and controls.
Fifty-eight patients were included in the study and during the study period, mean GCS levels improved in both groups; however, the difference was inconsiderable (p>0.05). Serum levels of fetuin-A, a negative phase reactant, increased in the group treated with citicoline (p=0.012), while these changes were insignificant for the controls (p=0.455). Serum levels of MGP, a calcification inhibitor, increased in the cases (p=0.046). The alterations were inconsequential in the control group (p=0.405).
The findings of this study suggest neutral effects of citicoline on level of consciousness and GCS. Through increasing levels of fetuin-A and MGP, citicoline may have protective effects against inflammatory damage and vascular calcification secondary to head trauma. Citicoline, a neuroprotective drug, has been suggested to improve level of consciousness, mitigating secondary to brain damage and ectopic vascular calcification, following post-traumatic neurogenesis and angiogenesis, inducing calcification modulators, like fetuin-A and matrix Gla-protein (MGP). This study aimed to investigate effects of citicoline on levels of consciousness, serum levels of fetuin-A and MGP in patients with severe traumatic brain injury.BACKGROUNDCiticoline, a neuroprotective drug, has been suggested to improve level of consciousness, mitigating secondary to brain damage and ectopic vascular calcification, following post-traumatic neurogenesis and angiogenesis, inducing calcification modulators, like fetuin-A and matrix Gla-protein (MGP). This study aimed to investigate effects of citicoline on levels of consciousness, serum levels of fetuin-A and MGP in patients with severe traumatic brain injury.This double blind randomized controlled trial (RCT) was conducted on patients with diagnosis of diffuse axonal injury (DAI) and GCS≤8. The cases were treated with citicoline (500 mg every 6 hours) intravenously for fifteen days. Daily GCS assessment and intermittent blood sampling were done for both cases and controls.METHODSThis double blind randomized controlled trial (RCT) was conducted on patients with diagnosis of diffuse axonal injury (DAI) and GCS≤8. The cases were treated with citicoline (500 mg every 6 hours) intravenously for fifteen days. Daily GCS assessment and intermittent blood sampling were done for both cases and controls.Fifty-eight patients were included in the study and during the study period, mean GCS levels improved in both groups; however, the difference was inconsiderable (p>0.05). Serum levels of fetuin-A, a negative phase reactant, increased in the group treated with citicoline (p=0.012), while these changes were insignificant for the controls (p=0.455). Serum levels of MGP, a calcification inhibitor, increased in the cases (p=0.046). The alterations were inconsequential in the control group (p=0.405).RESULTSFifty-eight patients were included in the study and during the study period, mean GCS levels improved in both groups; however, the difference was inconsiderable (p>0.05). Serum levels of fetuin-A, a negative phase reactant, increased in the group treated with citicoline (p=0.012), while these changes were insignificant for the controls (p=0.455). Serum levels of MGP, a calcification inhibitor, increased in the cases (p=0.046). The alterations were inconsequential in the control group (p=0.405).The findings of this study suggest neutral effects of citicoline on level of consciousness and GCS. Through increasing levels of fetuin-A and MGP, citicoline may have protective effects against inflammatory damage and vascular calcification secondary to head trauma.CONCLUSIONThe findings of this study suggest neutral effects of citicoline on level of consciousness and GCS. Through increasing levels of fetuin-A and MGP, citicoline may have protective effects against inflammatory damage and vascular calcification secondary to head trauma. |
| Author | Shokouhi, Ghaffar Haghjoo, Amir Ghorbani Asghari, Mohammad Sattarnezhad, Neda Asghari, Ali Sattarnezhad, Aida Pezeshki, Arastoo |
| Author_xml | – sequence: 1 givenname: Ghaffar surname: Shokouhi fullname: Shokouhi, Ghaffar organization: Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 2 givenname: Amir Ghorbani surname: Haghjoo fullname: Haghjoo, Amir Ghorbani organization: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 3 givenname: Neda surname: Sattarnezhad fullname: Sattarnezhad, Neda organization: Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 4 givenname: Mohammad surname: Asghari fullname: Asghari, Mohammad organization: Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 5 givenname: Aida surname: Sattarnezhad fullname: Sattarnezhad, Aida organization: Department of Pharmacy, Eastern Mediterranean University, Famagusta, Cyprus – sequence: 6 givenname: Ali surname: Asghari fullname: Asghari, Ali organization: Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 7 givenname: Arastoo surname: Pezeshki fullname: Pezeshki, Arastoo organization: Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25541919$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkEFOwzAQRS0EglLYs0JethIptmsn8bIqJVQqAglYV248Fq4Sp8QOtEfgHnAxTkJUimA1XzNPf77-Mdp3lQOEzigZCEHEZVgG8ANGKB8QkcRyD3XokCRRIrnY_6cP0RETglNJZQd9ToyBPHhcGZzbYPOqsA5w5XABr1Bs15Xzua0a78D7C-yhbsq_q4HQWBeNsHIalyrUdo2zQkWrugpgHe7dZvd93IpQq6ZUeKWCBdc-fLPhGWtrTOMBq3XlVNFiy6be4N7VaNrfGmbjh6_3j_QEHRhVeDjdzS56up48jm-i2V02HY9mUc4SGqKY8jjWRhnJNehkyCHlQhlmCAPGNDAtEpMKkgiQqTLpAqhWwhiaUCkXKWFd1PvxbdO_NODDvLQ-h6JQDtoC5jTmJBUtzlv0fIc2ixL0fFXbUtWb-W-17Buv3X0f |
| CitedBy_id | crossref_primary_10_3390_nu12103113 crossref_primary_10_3390_life13020369 crossref_primary_10_4103_1673_5374_382861 crossref_primary_10_3390_ijms222111313 crossref_primary_10_3390_ph14050410 crossref_primary_10_3390_brainsci11111504 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.5505/tjtes.2014.05769 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| EISSN | 1307-7945 |
| ExternalDocumentID | 25541919 |
| Genre | Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c271t-61466dfaf94ded734e845af2f02e22de2d57f85075e98af8be1da5ff17199b802 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 11 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000346128500003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1307-7945 |
| IngestDate | Fri Jul 11 11:54:42 EDT 2025 Thu Jan 02 22:26:02 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c271t-61466dfaf94ded734e845af2f02e22de2d57f85075e98af8be1da5ff17199b802 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://doi.org/10.5505/tjtes.2014.05769 |
| PMID | 25541919 |
| PQID | 1640851714 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1640851714 pubmed_primary_25541919 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-11-01 |
| PublicationDateYYYYMMDD | 2014-11-01 |
| PublicationDate_xml | – month: 11 year: 2014 text: 2014-11-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Turkey |
| PublicationPlace_xml | – name: Turkey |
| PublicationTitle | Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES |
| PublicationTitleAlternate | Ulus Travma Acil Cerrahi Derg |
| PublicationYear | 2014 |
| Score | 2.0076919 |
| Snippet | Citicoline, a neuroprotective drug, has been suggested to improve level of consciousness, mitigating secondary to brain damage and ectopic vascular... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 410 |
| SubjectTerms | Adolescent Adult Aged alpha-2-HS-Glycoprotein - metabolism Brain Injuries - blood Brain Injuries - complications Brain Injuries - drug therapy Calcium-Binding Proteins - blood Consciousness Cytidine Diphosphate Choline - administration & dosage Cytidine Diphosphate Choline - therapeutic use Diffuse Axonal Injury - complications Double-Blind Method Extracellular Matrix Proteins - blood Female Glasgow Coma Scale Humans Male Matrix Gla Protein Middle Aged Nootropic Agents - administration & dosage Nootropic Agents - therapeutic use Treatment Outcome Young Adult |
| Title | Effects of citicoline on level of consciousness, serum level of fetuin-A and matrix Gla-protein (MGP) in trauma patients with diffuse axonal injury (DAI) and GCS≤8 |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/25541919 https://www.proquest.com/docview/1640851714 |
| Volume | 20 |
| WOSCitedRecordID | wos000346128500003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NattAEF6aOodc-kPTxE1bptCDDVUirVfS6lSMW7s92BiSgm9mpZ0FG1t2I7nkFfIeyYv1STojyfhWCr0IoT_E7Le738zOzifERxP4PrKgiVOh9pRE6lJxKqlfqVQGNCFExq_EJuLJRM9mybQJuBVNWuV-TKwGarvJOEZ-RbSe2UEcqM_bnx6rRvHqaiOhcSRaPaIyjOp4Vu1-49qHBLWwXplkGn5VLom8cTKXuiSSEv2FU1Zzy_D5__7VC_GsYZXQr2HwUjzB_JV4rCsTF7BxkHGSG-vzIGxyWHGmUHWZMJdxFiwPeJ-A4LhbH-46LHeL3OuDyS2suZb_HYxWxqtqOyxy6IxH0y7QSXlrdmsDTY3WAji4Cyy9sisQzB2TfXpsSc0HnS_9793qg6PB9e_7B30qfgy_3gy-eY0qg5fJOCjJ11RRZJ1xibJo455CrULjpPMlSmlR2jB2mmhmiIk2TqcYWBM6R0ZKklT78rV4mm9yPBcQ2V6iiQJqpVKVImpyboJUZpEKM0tgaYsPe6vPCfW8lGFyJKPMD3Zvi7O66ebbujzHnJwkRV5o8uYf3r4QJwyIenPhW9Fy1OfxnTjOfpWL4vZ9BSc6TqbjP7zO15w |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+citicoline+on+level+of+consciousness%2C+serum+level+of+fetuin-A+and+matrix+Gla-protein+%28MGP%29+in+trauma+patients+with+diffuse+axonal+injury+%28DAI%29+and+GCS%E2%89%A48&rft.jtitle=Ulusal+travma+ve+acil+cerrahi+dergisi+%3D+Turkish+journal+of+trauma+%26+emergency+surgery+%3A+TJTES&rft.au=Shokouhi%2C+Ghaffar&rft.au=Haghjoo%2C+Amir+Ghorbani&rft.au=Sattarnezhad%2C+Neda&rft.au=Asghari%2C+Mohammad&rft.date=2014-11-01&rft.issn=1307-7945&rft.eissn=1307-7945&rft.volume=20&rft.issue=6&rft.spage=410&rft_id=info:doi/10.5505%2Ftjtes.2014.05769&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1307-7945&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1307-7945&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1307-7945&client=summon |