Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis: Results of Phase 1/2 and 2a Clinical Trials

Preclinical studies have shown that neurotrophic growth factors (NTFs) extend the survival of motor neurons in amyotrophic lateral sclerosis (ALS) and that the combined delivery of these neurotrophic factors has a strong synergistic effect. We have developed a culture-based method for inducing mesen...

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Veröffentlicht in:	JAMA neurology Jg. 73; H. 3; S. 337
Hauptverfasser:	Petrou, Panayiota, Gothelf, Yael, Argov, Zohar, Gotkine, Marc, Levy, Yossef S, Kassis, Ibrahim, Vaknin-Dembinsky, Adi, Ben-Hur, Tamir, Offen, Daniel, Abramsky, Oded, Melamed, Eldad, Karussis, Dimitrios
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.03.2016
Schlagworte:	Adult Aged Amyotrophic Lateral Sclerosis - therapy Female Follow-Up Studies Humans Male Mesenchymal Stem Cell Transplantation - adverse effects Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stromal Cells - secretion Middle Aged Nerve Growth Factors - secretion Outcome Assessment (Health Care) Transplantation, Autologous Young Adult
ISSN:	2168-6157, 2168-6157
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