Fast and Memory-Efficient Dynamic Programming Approach for Large-Scale EHH-Based Selection Scans

Abstract Haplotype-based statistics are widely used for finding genomic regions under positive selection. At the heart of many such statistics is the computation of extended haplotype homozygosity (EHH), which captures the decay of homozygosity away from a focal site. This computation, repeated for...

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Vydané v:	Molecular biology and evolution Ročník 42; číslo 11
Hlavní autori:	Rahman, Amatur, Smith, T Quinn, Szpiech, Zachary A
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	UK Oxford University Press 01.11.2025
Predmet:	Algorithms Computation Computer Simulation Dynamic Programming Genomics Genotypes Haplotypes Homozygosity Homozygote Humans Machine learning Models, Genetic Positive selection Run time (computers) Selection, Genetic Software Source code Statistics population genetics haplotypes positive selection software
ISSN:	0737-4038, 1537-1719, 1537-1719
On-line prístup:	Získať plný text
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