Preparation and Study of Solid Dispersions of Acyclovir with Starch and Carboxymethylcellulose

Solid dispersions based on acyclovir and polysaccharides (starch and sodium carboxymethylcellulose) have been prepared by means of mechanochemistry. Mechanical co-processing of the drug and the polymers in a ball mill, an extruder, and a pulse mechanical action cell has led to amorphization of acycl...

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Bibliographic Details
Published in:Polymer science. Series C Vol. 66; no. 1; pp. 39 - 45
Main Authors: Kryuk, T. V., Popyrina, T. N., Romanenko, N. A., Ivanov, P. L., Svishcheva, N. B., Akopova, T. A., Khavpachev, M. A.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01.09.2024
Springer Nature B.V
Subjects:
Aluminum
Amorphization
Bioavailability
Carboxymethyl cellulose
Chemistry
Chemistry and Materials Science
Dispersions
Drug delivery systems
Drug dosages
Explosions
Pharmaceuticals
Polymer Sciences
Polymers
Polysaccharides
Reagents
Rheology
Shear stress
United States > US
Japan
Germany
Russia
ISSN:1811-2382, 1555-614X
Online Access:Get full text
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Summary:Solid dispersions based on acyclovir and polysaccharides (starch and sodium carboxymethylcellulose) have been prepared by means of mechanochemistry. Mechanical co-processing of the drug and the polymers in a ball mill, an extruder, and a pulse mechanical action cell has led to amorphization of acyclovir, followed by its uniform distribution in the polymer matrix. A set of the IR and UV spectroscopy, DSC, and X-ray diffraction analysis data has revealed the presence of intermolecular interactions between the polysaccharide matrix and the drug. The obtained materials can be considered as potential system for further investigation as solid formulations of acyclovir with improved bioavailability.
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ISSN:1811-2382
1555-614X
DOI:10.1134/S1811238224600101