Primary lymphocytic hypophysitis: Clinical characteristics and treatment of 50 cases in a single centre in China over 18 years

Summary Objective Primary lymphocytic hypophysitis (LYH) is rare, and it is often evaluated in a small case series. This study aimed to describe the diagnosis and treatment of primary LYH in a larger cohort. Design A retrospective study of the diagnosis and treatment of primary LYH was conducted at...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical endocrinology (Oxford) Jg. 87; H. 2; S. 177 - 184
Hauptverfasser:	Wang, Shuchang, Wang, Linjie, Yao, Yong, Feng, Feng, Yang, Hongbo, Liang, Zhiyong, Deng, Kan, You, Hui, Sun, Jian, Xing, Bing, Jin, Zimeng, Wang, Renzhi, Pan, Hui, Zhu, Huijuan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Wiley Subscription Services, Inc 01.08.2017
Schlagworte:	Adrenal Insufficiency - complications Adrenocorticotropic hormone Autoimmune Hypophysitis - diagnosis Autoimmune Hypophysitis - diagnostic imaging Autoimmune Hypophysitis - drug therapy China Diabetes insipidus Diabetes Insipidus, Neurogenic - complications Follicle-stimulating hormone Glucocorticoids Glucocorticoids - therapeutic use Hypogonadism Hypogonadism - complications Insulin-like growth factor I Insulin-Like Growth Factor I - deficiency Logistic Models Luteinizing hormone lymphocytic hypophysitis Magnetic Resonance Imaging Medical diagnosis Pituitary (anterior) Pituitary Gland - pathology Pituitary Hormones, Anterior - deficiency Retrospective Studies surgery treatment treatment glucocorticoids lymphocytic hypophysitis surgery
ISSN:	0300-0664, 1365-2265, 1365-2265
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	Summary Objective Primary lymphocytic hypophysitis (LYH) is rare, and it is often evaluated in a small case series. This study aimed to describe the diagnosis and treatment of primary LYH in a larger cohort. Design A retrospective study of the diagnosis and treatment of primary LYH was conducted at Peking Union Medical College Hospital from 1999 to 2016. Patients Fifty patients (28 histologically diagnosed and 22 clinically‐diagnosed) were eligible for inclusion. Measurements Clinical, endocrine, pathological and imaging findings; therapies and outcomes were assessed. Ordinal logistic regression analysis was used to evaluate the association between the clinical parameters and outcomes (eg, improvements in pituitary function, regression of lesion size on MRI and disease recurrence). Results Central diabetes insipidus (CDI) (72.0%) was the most common endocrine dysfunction. Hypogonadotropic hypogonadism was the most frequently observed (60.0%) manifestation of anterior pituitary dysfunction; adrenal insufficiency was the third most common (26.0%) manifestation; and IGF‐1 axis defects were the least frequent (22.0%). Thickening of the pituitary stalk was the most frequent (96.0%) imaging finding, and 78.0% of the patients exhibited both intrasellar and suprasellar expansion. Pharmacological dose of glucocorticoids was identified to be significantly associated with increased odds of anterior pituitary function improvement. No observed covariates were significantly associated with improvement of CDI and recurrence. Conclusion The sequence of anterior pituitary deficiencies in Chinese primary LYH patients was atypical (LH/FSH>TSH>ACTH>IGF‐1 axis deficiency). A pharmacological dose of glucocorticoids was significantly associated with the improved anterior pituitary insufficiency.
AbstractList	Summary Objective Primary lymphocytic hypophysitis (LYH) is rare, and it is often evaluated in a small case series. This study aimed to describe the diagnosis and treatment of primary LYH in a larger cohort. Design A retrospective study of the diagnosis and treatment of primary LYH was conducted at Peking Union Medical College Hospital from 1999 to 2016. Patients Fifty patients (28 histologically diagnosed and 22 clinically‐diagnosed) were eligible for inclusion. Measurements Clinical, endocrine, pathological and imaging findings; therapies and outcomes were assessed. Ordinal logistic regression analysis was used to evaluate the association between the clinical parameters and outcomes (eg, improvements in pituitary function, regression of lesion size on MRI and disease recurrence). Results Central diabetes insipidus (CDI) (72.0%) was the most common endocrine dysfunction. Hypogonadotropic hypogonadism was the most frequently observed (60.0%) manifestation of anterior pituitary dysfunction; adrenal insufficiency was the third most common (26.0%) manifestation; and IGF‐1 axis defects were the least frequent (22.0%). Thickening of the pituitary stalk was the most frequent (96.0%) imaging finding, and 78.0% of the patients exhibited both intrasellar and suprasellar expansion. Pharmacological dose of glucocorticoids was identified to be significantly associated with increased odds of anterior pituitary function improvement. No observed covariates were significantly associated with improvement of CDI and recurrence. Conclusion The sequence of anterior pituitary deficiencies in Chinese primary LYH patients was atypical (LH/FSH>TSH>ACTH>IGF‐1 axis deficiency). A pharmacological dose of glucocorticoids was significantly associated with the improved anterior pituitary insufficiency. Primary lymphocytic hypophysitis (LYH) is rare, and it is often evaluated in a small case series. This study aimed to describe the diagnosis and treatment of primary LYH in a larger cohort. A retrospective study of the diagnosis and treatment of primary LYH was conducted at Peking Union Medical College Hospital from 1999 to 2016. Fifty patients (28 histologically diagnosed and 22 clinically-diagnosed) were eligible for inclusion. Clinical, endocrine, pathological and imaging findings; therapies and outcomes were assessed. Ordinal logistic regression analysis was used to evaluate the association between the clinical parameters and outcomes (eg, improvements in pituitary function, regression of lesion size on MRI and disease recurrence). Central diabetes insipidus (CDI) (72.0%) was the most common endocrine dysfunction. Hypogonadotropic hypogonadism was the most frequently observed (60.0%) manifestation of anterior pituitary dysfunction; adrenal insufficiency was the third most common (26.0%) manifestation; and IGF-1 axis defects were the least frequent (22.0%). Thickening of the pituitary stalk was the most frequent (96.0%) imaging finding, and 78.0% of the patients exhibited both intrasellar and suprasellar expansion. Pharmacological dose of glucocorticoids was identified to be significantly associated with increased odds of anterior pituitary function improvement. No observed covariates were significantly associated with improvement of CDI and recurrence. The sequence of anterior pituitary deficiencies in Chinese primary LYH patients was atypical (LH/FSH>TSH>ACTH>IGF-1 axis deficiency). A pharmacological dose of glucocorticoids was significantly associated with the improved anterior pituitary insufficiency. Primary lymphocytic hypophysitis (LYH) is rare, and it is often evaluated in a small case series. This study aimed to describe the diagnosis and treatment of primary LYH in a larger cohort.OBJECTIVEPrimary lymphocytic hypophysitis (LYH) is rare, and it is often evaluated in a small case series. This study aimed to describe the diagnosis and treatment of primary LYH in a larger cohort.A retrospective study of the diagnosis and treatment of primary LYH was conducted at Peking Union Medical College Hospital from 1999 to 2016.DESIGNA retrospective study of the diagnosis and treatment of primary LYH was conducted at Peking Union Medical College Hospital from 1999 to 2016.Fifty patients (28 histologically diagnosed and 22 clinically-diagnosed) were eligible for inclusion.PATIENTSFifty patients (28 histologically diagnosed and 22 clinically-diagnosed) were eligible for inclusion.Clinical, endocrine, pathological and imaging findings; therapies and outcomes were assessed. Ordinal logistic regression analysis was used to evaluate the association between the clinical parameters and outcomes (eg, improvements in pituitary function, regression of lesion size on MRI and disease recurrence).MEASUREMENTSClinical, endocrine, pathological and imaging findings; therapies and outcomes were assessed. Ordinal logistic regression analysis was used to evaluate the association between the clinical parameters and outcomes (eg, improvements in pituitary function, regression of lesion size on MRI and disease recurrence).Central diabetes insipidus (CDI) (72.0%) was the most common endocrine dysfunction. Hypogonadotropic hypogonadism was the most frequently observed (60.0%) manifestation of anterior pituitary dysfunction; adrenal insufficiency was the third most common (26.0%) manifestation; and IGF-1 axis defects were the least frequent (22.0%). Thickening of the pituitary stalk was the most frequent (96.0%) imaging finding, and 78.0% of the patients exhibited both intrasellar and suprasellar expansion. Pharmacological dose of glucocorticoids was identified to be significantly associated with increased odds of anterior pituitary function improvement. No observed covariates were significantly associated with improvement of CDI and recurrence.RESULTSCentral diabetes insipidus (CDI) (72.0%) was the most common endocrine dysfunction. Hypogonadotropic hypogonadism was the most frequently observed (60.0%) manifestation of anterior pituitary dysfunction; adrenal insufficiency was the third most common (26.0%) manifestation; and IGF-1 axis defects were the least frequent (22.0%). Thickening of the pituitary stalk was the most frequent (96.0%) imaging finding, and 78.0% of the patients exhibited both intrasellar and suprasellar expansion. Pharmacological dose of glucocorticoids was identified to be significantly associated with increased odds of anterior pituitary function improvement. No observed covariates were significantly associated with improvement of CDI and recurrence.The sequence of anterior pituitary deficiencies in Chinese primary LYH patients was atypical (LH/FSH>TSH>ACTH>IGF-1 axis deficiency). A pharmacological dose of glucocorticoids was significantly associated with the improved anterior pituitary insufficiency.CONCLUSIONThe sequence of anterior pituitary deficiencies in Chinese primary LYH patients was atypical (LH/FSH>TSH>ACTH>IGF-1 axis deficiency). A pharmacological dose of glucocorticoids was significantly associated with the improved anterior pituitary insufficiency. ObjectivePrimary lymphocytic hypophysitis (LYH) is rare, and it is often evaluated in a small case series. This study aimed to describe the diagnosis and treatment of primary LYH in a larger cohort.DesignA retrospective study of the diagnosis and treatment of primary LYH was conducted at Peking Union Medical College Hospital from 1999 to 2016.PatientsFifty patients (28 histologically diagnosed and 22 clinically‐diagnosed) were eligible for inclusion.MeasurementsClinical, endocrine, pathological and imaging findings; therapies and outcomes were assessed. Ordinal logistic regression analysis was used to evaluate the association between the clinical parameters and outcomes (eg, improvements in pituitary function, regression of lesion size on MRI and disease recurrence).ResultsCentral diabetes insipidus (CDI) (72.0%) was the most common endocrine dysfunction. Hypogonadotropic hypogonadism was the most frequently observed (60.0%) manifestation of anterior pituitary dysfunction; adrenal insufficiency was the third most common (26.0%) manifestation; and IGF‐1 axis defects were the least frequent (22.0%). Thickening of the pituitary stalk was the most frequent (96.0%) imaging finding, and 78.0% of the patients exhibited both intrasellar and suprasellar expansion. Pharmacological dose of glucocorticoids was identified to be significantly associated with increased odds of anterior pituitary function improvement. No observed covariates were significantly associated with improvement of CDI and recurrence.ConclusionThe sequence of anterior pituitary deficiencies in Chinese primary LYH patients was atypical (LH/FSH>TSH>ACTH>IGF‐1 axis deficiency). A pharmacological dose of glucocorticoids was significantly associated with the improved anterior pituitary insufficiency.
Author	Pan, Hui Wang, Linjie Yang, Hongbo Sun, Jian Zhu, Huijuan Jin, Zimeng Liang, Zhiyong Wang, Shuchang Feng, Feng Xing, Bing You, Hui Yao, Yong Deng, Kan Wang, Renzhi
Author_xml	– sequence: 1 givenname: Shuchang orcidid: 0000-0001-8191-1188 surname: Wang fullname: Wang, Shuchang organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 2 givenname: Linjie surname: Wang fullname: Wang, Linjie organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 3 givenname: Yong surname: Yao fullname: Yao, Yong organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 4 givenname: Feng surname: Feng fullname: Feng, Feng organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 5 givenname: Hongbo surname: Yang fullname: Yang, Hongbo organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 6 givenname: Zhiyong surname: Liang fullname: Liang, Zhiyong organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 7 givenname: Kan surname: Deng fullname: Deng, Kan organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 8 givenname: Hui surname: You fullname: You, Hui organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 9 givenname: Jian surname: Sun fullname: Sun, Jian organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 10 givenname: Bing surname: Xing fullname: Xing, Bing organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 11 givenname: Zimeng surname: Jin fullname: Jin, Zimeng organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 12 givenname: Renzhi surname: Wang fullname: Wang, Renzhi organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 13 givenname: Hui surname: Pan fullname: Pan, Hui email: panhui20111111@163.com organization: Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 14 givenname: Huijuan surname: Zhu fullname: Zhu, Huijuan email: shengxin2004@163.com organization: Chinese Academy of Medical Sciences and Peking Union Medical College
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28423475$$D View this record in MEDLINE/PubMed
BookMark	eNp1kc1u1DAUhS1URKeFBS-ALLEpi7T-iR2bHYpaWqkCFrC2bMchrhI72BmqrHgVnqVPhoeZbiq4mytdfefo6pwTcBRicAC8xugcl7mwLpxjSln9DGww5awihLMjsEEUoQpxXh-Dk5zvEEJMoOYFOCaiJrRu2Ab8-pL8pNMKx3Wah2jXxVs4rHOchzX7xef3sB198FaP0A46abu45HOhMtShg0tyeplcWGDsIUPQ6uwy9AFqmH34PjpYnivQ7tQOPmgYf7oEsXj4vTqd8kvwvNdjdq8O-xR8u7r82l5Xt58_3rQfbitLuKgrjQwzxhnTcCRqQ2VvMDF9x02jmSTW1jWXspOGoo6IxgpquCBGCIooa6ykp-Bs7zun-GPr8qImn60bRx1c3GaFhcRISMGbgr59gt7FbQrlO4UlFgKhhuwM3xyorZlcp-Z9juox2gJc7AGbYs7J9cr6RS8-lji0HxVGaleeKvmov-UVxbsnikfTf7EH93s_uvX_oGovP-0VfwAVwKj7
CitedBy_id	crossref_primary_10_1210_clinem_dgab839 crossref_primary_10_1016_j_jep_2019_111952 crossref_primary_10_1038_s41572_021_00252_7 crossref_primary_10_12998_wjcc_v10_i3_1041 crossref_primary_10_3389_fimmu_2024_1368572 crossref_primary_10_1111_jne_12954 crossref_primary_10_3389_fendo_2021_735655 crossref_primary_10_1007_s11154_024_09898_6 crossref_primary_10_1007_s00381_024_06680_6 crossref_primary_10_1210_clinem_dgab672 crossref_primary_10_1177_0300060519887832 crossref_primary_10_1016_j_jocn_2020_08_001 crossref_primary_10_1093_ejendo_lvae101 crossref_primary_10_1080_07435800_2020_1817064 crossref_primary_10_1210_jc_2018_01021 crossref_primary_10_1210_jc_2018_02297 crossref_primary_10_4158_EP_2018_0550 crossref_primary_10_1007_s11102_022_01232_0 crossref_primary_10_1007_s11102_022_01274_4 crossref_primary_10_1080_17446651_2019_1598260 crossref_primary_10_1111_cen_15075 crossref_primary_10_1016_j_endinu_2023_01_001 crossref_primary_10_1016_S2352_4642_21_00088_2 crossref_primary_10_1016_j_wneu_2022_12_108 crossref_primary_10_1016_j_endien_2023_01_001 crossref_primary_10_1016_j_eprac_2022_06_009 crossref_primary_10_1016_j_ncl_2018_09_001 crossref_primary_10_1155_2018_7637435 crossref_primary_10_1007_s11547_019_01120_x crossref_primary_10_7759_cureus_59396 crossref_primary_10_4158_EP171969_VV crossref_primary_10_1016_j_beem_2019_101371 crossref_primary_10_1016_j_tem_2019_06_004 crossref_primary_10_1097_MD_0000000000041232 crossref_primary_10_1016_j_yaoo_2020_05_013 crossref_primary_10_1016_S1155_1941_24_46684_5 crossref_primary_10_1007_s11154_018_9480_1 crossref_primary_10_1016_j_wneu_2019_01_250 crossref_primary_10_1016_j_wneu_2018_03_086 crossref_primary_10_1093_ejendo_lvad003 crossref_primary_10_1089_whr_2019_0028
Cites_doi	10.1159/000110611 10.3174/ajnr.A1714 10.1097/00006123-200005000-00053 10.1007/s004310050690 10.18632/oncotarget.9618 10.1007/s11102-014-0622-5 10.1007/BF02739954 10.1159/000446544 10.3171/jns.2004.101.2.0262 10.1227/00006123-199505000-00018 10.1210/jc.2009-1097 10.3803/EnM.2014.29.4.470 10.1007/s11102-016-0769-3 10.3171/jns.2003.99.3.0591 10.1210/jc.2015-2152 10.1007/s11102-016-0736-z 10.1016/j.autrev.2014.01.021 10.1210/jc.2015-2146 10.1007/s11102-006-6598-z 10.1210/er.2004-0011 10.1111/j.1365-2265.2009.03765.x 10.1136/jnnp.67.3.398 10.1007/s701-002-8273-5 10.4103/1008-682X.145072 10.1080/02688690120057664 10.1080/07435800902841306 10.1007/s11102-013-0550-9 10.1210/jc.2010-1692 10.1097/00006123-199704000-00010 10.1530/eje.1.02183 10.1210/jc.2009-2354
ContentType	Journal Article
Copyright	2017 John Wiley & Sons Ltd 2017 John Wiley & Sons Ltd. Copyright © 2017 John Wiley & Sons Ltd
Copyright_xml	– notice: 2017 John Wiley & Sons Ltd – notice: 2017 John Wiley & Sons Ltd. – notice: Copyright © 2017 John Wiley & Sons Ltd
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QP K9. NAPCQ 7X8
DOI	10.1111/cen.13354
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Calcium & Calcified Tissue Abstracts ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Calcium & Calcified Tissue Abstracts MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic ProQuest Health & Medical Complete (Alumni)
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1365-2265
EndPage	184
ExternalDocumentID	28423475 10_1111_cen_13354 CEN13354
Genre	article Journal Article
GrantInformation_xml	– fundername: National Key Program of Clinical Science, China funderid: WBYZ2011‐873
GroupedDBID	--- .3N .55 .GA .GJ .Y3 05W 08P 0R~ 10A 1OB 1OC 29B 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 6J9 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AAHQN AAIPD AAKAS AAMNL AANHP AANLZ AAONW AAQQT AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABJNI ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZCM ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFWVQ AFZJQ AHBTC AHEFC AHMBA AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 DUUFO EBS EJD EMOBN ESX EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M J5H K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MJL MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 R.K REN RIWAO RJQFR ROL RX1 SAMSI SUPJJ TEORI UB1 V8K W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WRC WUP WVDHM WXI WXSBR X7M XG1 YOC YUY ZGI ZXP ZZTAW ~IA ~WT AAMMB AAYXX AEFGJ AEYWJ AGHNM AGQPQ AGXDD AGYGG AIDQK AIDYY AIQQE CITATION O8X CGR CUY CVF ECM EIF NPM 7QP K9. NAPCQ 7X8
ID	FETCH-LOGICAL-c2684-a0b5bbebb76084b39fb12bfd6b7a592cc44699d9b30d287c83b682b8830357c93
IEDL.DBID	DRFUL
ISSN	0300-0664 1365-2265
IngestDate	Fri Sep 05 13:08:52 EDT 2025 Mon Oct 06 18:02:42 EDT 2025 Wed Feb 19 02:44:08 EST 2025 Sat Nov 29 02:50:18 EST 2025 Tue Nov 18 21:58:03 EST 2025 Wed Jan 22 16:42:30 EST 2025
IsPeerReviewed	true
IsScholarly	true
Issue	2
Keywords	treatment glucocorticoids lymphocytic hypophysitis surgery
Language	English
License	http://onlinelibrary.wiley.com/termsAndConditions#vor 2017 John Wiley & Sons Ltd.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c2684-a0b5bbebb76084b39fb12bfd6b7a592cc44699d9b30d287c83b682b8830357c93
Notes	Funding information This study was supported by a grant from the National Key Program of Clinical Science (National Health Family Planning Commission), China (WBYZ2011‐873). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0001-8191-1188
PMID	28423475
PQID	1918800729
PQPubID	36523
PageCount	8
ParticipantIDs	proquest_miscellaneous_1891089867 proquest_journals_1918800729 pubmed_primary_28423475 crossref_citationtrail_10_1111_cen_13354 crossref_primary_10_1111_cen_13354 wiley_primary_10_1111_cen_13354_CEN13354
PublicationCentury	2000
PublicationDate	August 2017 2017-08-00 2017-Aug 20170801
PublicationDateYYYYMMDD	2017-08-01
PublicationDate_xml	– month: 08 year: 2017 text: August 2017
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England – name: Oxford
PublicationTitle	Clinical endocrinology (Oxford)
PublicationTitleAlternate	Clin Endocrinol (Oxf)
PublicationYear	2017
Publisher	Wiley Subscription Services, Inc
Publisher_xml	– name: Wiley Subscription Services, Inc
References	2004; 101 2017; 20 1997; 40 2015; 17 2016; 19 2015; 18 1995; 36 2000; 46 2015; 100 2006; 9 1997; 156 1999; 67 2011; 96 1992 2014; 29 2005; 26 2001; 22 2006; 155 2003; 99 2009; 34 2016; 7 2009; 30 2009; 94 2009; 50 2002; 144 2014; 13 2001; 15 2007; 68 2017; 104 2010; 73 2010; 95 1998; 9 e_1_2_6_32_1 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_30_1 Reeves WB (e_1_2_6_22_1) 1992 e_1_2_6_19_1 Thorner MO (e_1_2_6_17_1) 1992 e_1_2_6_13_1 e_1_2_6_14_1 e_1_2_6_35_1 e_1_2_6_11_1 e_1_2_6_34_1 e_1_2_6_12_1 e_1_2_6_33_1 Menon SK (e_1_2_6_36_1) 2009; 50 e_1_2_6_18_1 Nakasu Y (e_1_2_6_29_1) 2001; 22 e_1_2_6_15_1 e_1_2_6_16_1 e_1_2_6_21_1 e_1_2_6_20_1 e_1_2_6_9_1 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_4_1 e_1_2_6_7_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_28_1 e_1_2_6_27_1 e_1_2_6_26_1
References_xml	– volume: 18 start-page: 630 year: 2015 end-page: 641 article-title: Hypophysitis: a single‐center case series publication-title: Pituitary – volume: 99 start-page: 591 year: 2003 end-page: 596 article-title: Stereotactic radiotherapy for the treatment of lymphocytic hypophysitis. Report of two cases publication-title: J Neurosurg – volume: 36 start-page: 1009 year: 1995 end-page: 1012 article-title: Candidal pituitary abscess: case report publication-title: Neurosurgery – volume: 29 start-page: 470 year: 2014 end-page: 478 article-title: Clinical characteristics, management, and outcome of 22 cases of primary hypophysitis publication-title: Endocrinol Metab (Seoul) – volume: 40 start-page: 713 year: 1997 end-page: 722 article-title: Lymphocytic and granulomatous hypophysitis: experience with nine cases publication-title: Neurosurgery – volume: 15 start-page: 242 year: 2001 end-page: 245 article-title: Lymphocytic and granulocytic hypophysitis: a single centre experience publication-title: Br J Neurosurg – volume: 26 start-page: 599 year: 2005 end-page: 614 article-title: Autoimmune hypophysitis publication-title: Endocr Rev – volume: 155 start-page: 101 year: 2006 end-page: 107 article-title: Primary hypophysitis: clinical‐pathological correlations publication-title: Eur J Endocrinol – volume: 68 start-page: 145 issue: Suppl 5 year: 2007 end-page: 150 article-title: Lymphocytic hypophysitis publication-title: Horm Res – volume: 104 start-page: 280 year: 2017 end-page: 290 article-title: An overview of diagnosis of primary autoimmune hypophysitis in a single prospective monocentric experience publication-title: Neuroendocrinology – volume: 9 start-page: 71 year: 1998 end-page: 78 article-title: Lymphocytic hypophysitis: light and electron microscopic findings and correlation to clinical appearance publication-title: Endocr Pathol – volume: 95 start-page: 2536 year: 2010 end-page: 2559 article-title: Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline publication-title: J Clin Endocrinol Metab – volume: 100 start-page: 3841 year: 2015 end-page: 3849 article-title: Diagnosis of primary hypophysitis in Germany publication-title: J Clin Endocrinol Metab – volume: 22 start-page: 1528 year: 2001 end-page: 1533 article-title: Tentorial enhancement on MR images is a sign of cavernous sinus involvement in patients with sellar tumors publication-title: AJNR Am J Neuroradiol – volume: 30 start-page: 1766 year: 2009 end-page: 1772 article-title: A radiologic score to distinguish autoimmune hypophysitis from nonsecreting pituitary adenoma preoperatively publication-title: AJNR Am J Neuroradiol – volume: 17 start-page: 497 year: 2015 end-page: 502 article-title: Reversal of idiopathic hypogonadotropic hypogonadism: a cohort study in Chinese patients publication-title: Asian J Androl – volume: 101 start-page: 262 year: 2004 end-page: 271 article-title: Primary hypophysitis: a single‐center experience in 16 cases publication-title: J Neurosurg – volume: 19 start-page: 625 year: 2016 end-page: 642 article-title: Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects publication-title: Pituitary – volume: 20 start-page: 241 year: 2017 end-page: 250 article-title: Lymphocytic hypophysitis: modern day management with limited role for surgery publication-title: Pituitary – volume: 7 start-page: 43557 year: 2016 end-page: 43569 article-title: Targeted next‐generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis publication-title: Oncotarget – volume: 13 start-page: 412 year: 2014 end-page: 416 article-title: Diagnosis and classification of autoimmune hypophysitis publication-title: Autoimmun Rev – volume: 96 start-page: 273 year: 2011 end-page: 288 article-title: Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline publication-title: J Clin Endocrinol Metab – volume: 46 start-page: 1268 year: 2000 article-title: Lymphocytic and granulomatous hypophysitis: experience with nine cases publication-title: Neurosurgery – volume: 100 start-page: 3460 year: 2015 end-page: 3469 article-title: Treatment of primary hypophysitis in Germany publication-title: J Clin Endocrinol Metab – volume: 94 start-page: 4216 year: 2009 end-page: 4223 article-title: ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly publication-title: J Clin Endocrinol Metab – volume: 18 start-page: 16 year: 2015 end-page: 22 article-title: Primary (autoimmune) hypophysitis: a single centre experience publication-title: Pituitary – volume: 50 start-page: 1080 year: 2009 end-page: 1084 article-title: Autoimmune hypophysitis: a single centre experience publication-title: Singapore Med J – volume: 156 start-page: 684 year: 1997 end-page: 688 article-title: Lymphocytic hypophysitis presenting with diabetes insipidus in a 14‐year‐old girl: case report and review of the literature publication-title: Eur J Pediatr – start-page: 252 year: 1992 end-page: 253 – volume: 73 start-page: 18 year: 2010 end-page: 21 article-title: How reliably can autoimmune hypophysitis be diagnosed without pituitary biopsy publication-title: Clin Endocrinol (Oxf) – volume: 67 start-page: 398 year: 1999 end-page: 402 article-title: Lymphocytic hypophysitis: non‐invasive diagnosis and treatment by high dose methylprednisolone pulse therapy? publication-title: J Neurol Neurosurg Psychiatry – volume: 144 start-page: 47 year: 2002 end-page: 56 article-title: Inflammatory hypophysitis—the spectrum of disease publication-title: Acta Neurochir (Wien) – start-page: 333 year: 1992 end-page: 338 – volume: 34 start-page: 10 year: 2009 end-page: 17 article-title: Empty sella may be the final outcome in lymphocytic hypophysitis publication-title: Endocr Res – volume: 9 start-page: 35 year: 2006 end-page: 45 article-title: Lymphocytic hypophysitis: disease spectrum and approach to diagnosis and therapy publication-title: Pituitary – ident: e_1_2_6_30_1 doi: 10.1159/000110611 – ident: e_1_2_6_16_1 doi: 10.3174/ajnr.A1714 – ident: e_1_2_6_28_1 doi: 10.1097/00006123-200005000-00053 – ident: e_1_2_6_8_1 doi: 10.1007/s004310050690 – ident: e_1_2_6_14_1 doi: 10.18632/oncotarget.9618 – ident: e_1_2_6_24_1 doi: 10.1007/s11102-014-0622-5 – ident: e_1_2_6_3_1 doi: 10.1007/BF02739954 – ident: e_1_2_6_31_1 doi: 10.1159/000446544 – ident: e_1_2_6_33_1 doi: 10.3171/jns.2004.101.2.0262 – ident: e_1_2_6_27_1 doi: 10.1227/00006123-199505000-00018 – ident: e_1_2_6_18_1 doi: 10.1210/jc.2009-1097 – ident: e_1_2_6_26_1 doi: 10.3803/EnM.2014.29.4.470 – ident: e_1_2_6_6_1 doi: 10.1007/s11102-016-0769-3 – ident: e_1_2_6_13_1 doi: 10.3171/jns.2003.99.3.0591 – ident: e_1_2_6_25_1 doi: 10.1210/jc.2015-2152 – ident: e_1_2_6_2_1 doi: 10.1007/s11102-016-0736-z – start-page: 252 volume-title: Williams Textbook of Endocrinology year: 1992 ident: e_1_2_6_17_1 – ident: e_1_2_6_5_1 doi: 10.1016/j.autrev.2014.01.021 – ident: e_1_2_6_32_1 doi: 10.1210/jc.2015-2146 – ident: e_1_2_6_4_1 doi: 10.1007/s11102-006-6598-z – volume: 22 start-page: 1528 year: 2001 ident: e_1_2_6_29_1 article-title: Tentorial enhancement on MR images is a sign of cavernous sinus involvement in patients with sellar tumors publication-title: AJNR Am J Neuroradiol – ident: e_1_2_6_11_1 doi: 10.1210/er.2004-0011 – volume: 50 start-page: 1080 year: 2009 ident: e_1_2_6_36_1 article-title: Autoimmune hypophysitis: a single centre experience publication-title: Singapore Med J – ident: e_1_2_6_15_1 doi: 10.1111/j.1365-2265.2009.03765.x – ident: e_1_2_6_9_1 doi: 10.1136/jnnp.67.3.398 – ident: e_1_2_6_35_1 doi: 10.1007/s701-002-8273-5 – ident: e_1_2_6_20_1 doi: 10.4103/1008-682X.145072 – start-page: 333 volume-title: Williams Textbook of Endocrinology year: 1992 ident: e_1_2_6_22_1 – ident: e_1_2_6_34_1 doi: 10.1080/02688690120057664 – ident: e_1_2_6_10_1 doi: 10.1080/07435800902841306 – ident: e_1_2_6_23_1 doi: 10.1007/s11102-013-0550-9 – ident: e_1_2_6_21_1 doi: 10.1210/jc.2010-1692 – ident: e_1_2_6_7_1 doi: 10.1097/00006123-199704000-00010 – ident: e_1_2_6_12_1 doi: 10.1530/eje.1.02183 – ident: e_1_2_6_19_1 doi: 10.1210/jc.2009-2354
SSID	ssj0005807
Score	2.4487498
Snippet	Summary Objective Primary lymphocytic hypophysitis (LYH) is rare, and it is often evaluated in a small case series. This study aimed to describe the diagnosis... Primary lymphocytic hypophysitis (LYH) is rare, and it is often evaluated in a small case series. This study aimed to describe the diagnosis and treatment of... ObjectivePrimary lymphocytic hypophysitis (LYH) is rare, and it is often evaluated in a small case series. This study aimed to describe the diagnosis and...
SourceID	proquest pubmed crossref wiley
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	177
SubjectTerms	Adrenal Insufficiency - complications Adrenocorticotropic hormone Autoimmune Hypophysitis - diagnosis Autoimmune Hypophysitis - diagnostic imaging Autoimmune Hypophysitis - drug therapy China Diabetes insipidus Diabetes Insipidus, Neurogenic - complications Follicle-stimulating hormone Glucocorticoids Glucocorticoids - therapeutic use Hypogonadism Hypogonadism - complications Insulin-like growth factor I Insulin-Like Growth Factor I - deficiency Logistic Models Luteinizing hormone lymphocytic hypophysitis Magnetic Resonance Imaging Medical diagnosis Pituitary (anterior) Pituitary Gland - pathology Pituitary Hormones, Anterior - deficiency Retrospective Studies surgery treatment
Title	Primary lymphocytic hypophysitis: Clinical characteristics and treatment of 50 cases in a single centre in China over 18 years
URI	https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcen.13354 https://www.ncbi.nlm.nih.gov/pubmed/28423475 https://www.proquest.com/docview/1918800729 https://www.proquest.com/docview/1891089867
Volume	87
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVWIB databaseName: Wiley Online Library - Journals customDbUrl: eissn: 1365-2265 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005807 issn: 0300-0664 databaseCode: DRFUL dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB61W4S4UN4slGpAHLgEZZM4tuFUla44lFWFKNpb5FfUSqukatpKe-pf4bf0l3XseAMrQELiFsUT2fF4PA_PfAZ46_hEO61EQq1FUvgyGWlT2gy9buPUZEPA7fshn83EfC6PNuDjqhamx4cYAm5eMsJ-7QVc6e4XITeueU8OFis2YSujdctGsPXp6_T48GeGR6yWzn3xdFkWEVjIJ_IMH6-ro99szHWTNeic6fZ_jfYB3I-mJu71a-MhbLjmEdz9Eg_TH8P1UY80gYslsbQ1S6LDk-VZG6IdF6fdB4yooQs067jOqBqLQ446tjWyFA0pxA5PG1ToAxALhyHz0_lX4Zpu9OmiOBE3P5YkX90TOJ4efNv_nMT7GBLjMWESlWqmiX2al6kodC5rPcl0bUvNFZOZMeRaSmmlzlNLjpgRuS5FpoUgNcm4kflTGDVt454DWu6UrJ2c1MoWZWEly3Wau1ppZkVmxBjerdhSmQhW7u_MWFQrp4X-oAoTOoY3A-lZP29_ItpZ8baKQtpV5KrS7uWh08fwemgm8fJnJqpx7SXRCLKnhBQlH8Ozfk0MvZBmz_KCMxpsYP3fu6_2D2bh4cW_k76Ee5k3IUKy4Q6MLs4v3Su4Y66I_-e7sMnnYjeu-FskAwP0
linkProvider	Wiley-Blackwell
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB6VFgEXypuFAgPiwCUomzixjbhUpatW3a4q1KLeIr8iKq2SqttW2lP_Cr-FX8bY8aZdARIStyieyI5nxvPw-DPAe8eH2mklEmplCfPHZKRNaTH0to1Tkw0Jt29jPpmI42N5sAKfF2dhOnyIPuHmNSOs117BfUL6hpYb13ykCKtgt2CNkRiRfK99-To6Gl-XeMTj0rk_PV2WLCIL-Uqe_uNle_Sbk7nsswajM1r_v-E-gPvR2cTNTjoewoprHsGd_bid_hiuDjqsCZzOiamtmRMdfp-ftiHfcX4y-4QRN3SKZhnZGVVjsa9Sx7bGIkVDJnGGJw0q9CmIqcNQ--n8q3BRN_qCURyKnz_mpGGzJ3A02j7c2knijQyJ8agwiUp1oYmBmpepYDqXtR5mural5qqQmTEUXEpppc5TS6GYEbkuRaaFIENZcCPzp7DatI17Dmi5U7J2clgry0pmZZHrNHe10oUVmRED-LDgS2UiXLm_NWNaLcIW-oMqTOgA3vWkp928_YloY8HcKqrprKJgldYvD54-gLd9MymY3zVRjWsviEaQRyWkKPkAnnVC0fdCtj3LGS9osIH3f---2tqehIcX_076Bu7uHO6Pq_HuZO8l3Mu8QxFKDzdg9fzswr2C2-aSZOHsdRT8X4u-Bvw
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR3LbtQwcFS2qOJCebO0wIA4cAnKJk5sV1xQ2xWIZbVCFPUW-RVRaZWsui3SnvgVvoUv69jxBlaAhMQtiiey45nxPDwPgBeOj7TTSiQ0yhLm02SkTekw9LKN05ANDrfPEz6ditNTOduC1-tcmK4-RO9w85wRzmvP4G5h61-43LjmFVlYBbsG28w3kRnA9tHH8cnkZ4hHTJfOffZ0WbJYWchH8vQfb8qj35TMTZ01CJ3x7v8t9xbcjMomvumo4zZsueYO7HyI1-l34dusqzWB8xUhtTUrgsMvq0Ub_B0XZ8sDjHVD52g2Kzujaiz2UerY1likaEgkLvGsQYXeBTF3GGI_nX8VGnWjDxjFkfjxfUUctrwHJ-PjT4dvk9iRITG-KkyiUl1oQqDmZSqYzmWtR5mubam5KmRmDBmXUlqp89SSKWZErkuRaSFIUBbcyPw-DJq2cQ8BLXdK1k6OamVZyawscp3mrla6sCIzYggv13ipTCxX7rtmzKu12UJ_UIUNHcLzHnTR7dufgPbXyK0imy4rMlbp_PLF04fwrB8mBvO3Jqpx7SXBCNKohBQlH8KDjij6WUi2ZznjBS024P7v01eHx9Pw8OjfQZ_CzuxoXE3eTd_vwY3M6xMh8nAfBhfnl-4xXDdfiRTOn0S6vwINdAZ3
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Primary+lymphocytic+hypophysitis%3A+Clinical+characteristics+and+treatment+of+50+cases+in+a+single+centre+in+China+over+18%C2%A0years&rft.jtitle=Clinical+endocrinology+%28Oxford%29&rft.au=Wang%2C+Shuchang&rft.au=Wang%2C+Linjie&rft.au=Yao%2C+Yong&rft.au=Feng%2C+Feng&rft.date=2017-08-01&rft.issn=0300-0664&rft.eissn=1365-2265&rft.volume=87&rft.issue=2&rft.spage=177&rft.epage=184&rft_id=info:doi/10.1111%2Fcen.13354&rft.externalDBID=10.1111%252Fcen.13354&rft.externalDocID=CEN13354
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0300-0664&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0300-0664&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0300-0664&client=summon