microRNA‐146a and ‐155, upregulated by periodontitis and type 2 diabetes in oral fluids, are predicted to regulate SARS‐CoV‐2 oral receptor genes
Background Type 2 diabetes and periodontitis predispose to a higher risk of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Recent studies show upregulation of innate immuno‐regulatory microRNA‐146a and ‐155 in oral fluids of patients with type 2 diabetes as well as of patien...
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| Published in: | Journal of periodontology (1970) Vol. 92; no. 7; pp. 35 - 43 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
01.07.2021
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| ISSN: | 0022-3492, 1943-3670, 1943-3670 |
| Online Access: | Get full text |
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| Abstract | Background
Type 2 diabetes and periodontitis predispose to a higher risk of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Recent studies show upregulation of innate immuno‐regulatory microRNA‐146a and ‐155 in oral fluids of patients with type 2 diabetes as well as of patients with periodontitis. The aim was to investigate whether upregulation of these microRNAs may relate to patient susceptibility to the infection via modulation of SARS‐CoV‐2 cellular entry factors expression.
Methods
Due to limited experimental feasibility and health risks in Coronavirus Disease 2019, bioinformatic analyses combining with system biology were used as initial investigation of interaction between microRNA‐146 and ‐155 and genes encoding SARS‐CoV‐2 entry factors.
Results
SARS‐CoV‐2 cellular entry factors are expressed in salivary glands and masticatory mucosa (tongue) at different expression levels, comparable with those measured in lungs and tonsil. MicroRNA‐146 and ‐155 are widely involved in the regulation of SARS‐CoV‐2 oral cellular entry factors and may enhance expression of ACE2 and modulate genes involved in host immunity.
Conclusions
Diabetes‐ and periodontitis‐induced increase in microRNA‐146a and ‐155 in oral cavity is predicted to upregulate angiotensin‐converting enzyme 2 expression, essential SARS‐CoV‐2 entry receptors, and modulate host antiviral response. As it could suggest increased infectivity of diabetes and periodontitis patients, additional protective measures for periodontists are recommended. |
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| AbstractList | Background
Type 2 diabetes and periodontitis predispose to a higher risk of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Recent studies show upregulation of innate immuno‐regulatory microRNA‐146a and ‐155 in oral fluids of patients with type 2 diabetes as well as of patients with periodontitis. The aim was to investigate whether upregulation of these microRNAs may relate to patient susceptibility to the infection via modulation of SARS‐CoV‐2 cellular entry factors expression.
Methods
Due to limited experimental feasibility and health risks in Coronavirus Disease 2019, bioinformatic analyses combining with system biology were used as initial investigation of interaction between microRNA‐146 and ‐155 and genes encoding SARS‐CoV‐2 entry factors.
Results
SARS‐CoV‐2 cellular entry factors are expressed in salivary glands and masticatory mucosa (tongue) at different expression levels, comparable with those measured in lungs and tonsil. MicroRNA‐146 and ‐155 are widely involved in the regulation of SARS‐CoV‐2 oral cellular entry factors and may enhance expression of ACE2 and modulate genes involved in host immunity.
Conclusions
Diabetes‐ and periodontitis‐induced increase in microRNA‐146a and ‐155 in oral cavity is predicted to upregulate angiotensin‐converting enzyme 2 expression, essential SARS‐CoV‐2 entry receptors, and modulate host antiviral response. As it could suggest increased infectivity of diabetes and periodontitis patients, additional protective measures for periodontists are recommended. Type 2 diabetes and periodontitis predispose to a higher risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recent studies show upregulation of innate immuno-regulatory microRNA-146a and -155 in oral fluids of patients with type 2 diabetes as well as of patients with periodontitis. The aim was to investigate whether upregulation of these microRNAs may relate to patient susceptibility to the infection via modulation of SARS-CoV-2 cellular entry factors expression.BACKGROUNDType 2 diabetes and periodontitis predispose to a higher risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recent studies show upregulation of innate immuno-regulatory microRNA-146a and -155 in oral fluids of patients with type 2 diabetes as well as of patients with periodontitis. The aim was to investigate whether upregulation of these microRNAs may relate to patient susceptibility to the infection via modulation of SARS-CoV-2 cellular entry factors expression.Due to limited experimental feasibility and health risks in Coronavirus Disease 2019, bioinformatic analyses combining with system biology were used as initial investigation of interaction between microRNA-146 and -155 and genes encoding SARS-CoV-2 entry factors.METHODSDue to limited experimental feasibility and health risks in Coronavirus Disease 2019, bioinformatic analyses combining with system biology were used as initial investigation of interaction between microRNA-146 and -155 and genes encoding SARS-CoV-2 entry factors.SARS-CoV-2 cellular entry factors are expressed in salivary glands and masticatory mucosa (tongue) at different expression levels, comparable with those measured in lungs and tonsil. MicroRNA-146 and -155 are widely involved in the regulation of SARS-CoV-2 oral cellular entry factors and may enhance expression of ACE2 and modulate genes involved in host immunity.RESULTSSARS-CoV-2 cellular entry factors are expressed in salivary glands and masticatory mucosa (tongue) at different expression levels, comparable with those measured in lungs and tonsil. MicroRNA-146 and -155 are widely involved in the regulation of SARS-CoV-2 oral cellular entry factors and may enhance expression of ACE2 and modulate genes involved in host immunity.Diabetes- and periodontitis-induced increase in microRNA-146a and -155 in oral cavity is predicted to upregulate angiotensin-converting enzyme 2 expression, essential SARS-CoV-2 entry receptors, and modulate host antiviral response. As it could suggest increased infectivity of diabetes and periodontitis patients, additional protective measures for periodontists are recommended.CONCLUSIONSDiabetes- and periodontitis-induced increase in microRNA-146a and -155 in oral cavity is predicted to upregulate angiotensin-converting enzyme 2 expression, essential SARS-CoV-2 entry receptors, and modulate host antiviral response. As it could suggest increased infectivity of diabetes and periodontitis patients, additional protective measures for periodontists are recommended. |
| Author | Roganović, Jelena R. |
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| Cites_doi | 10.1016/j.bone.2019.115041 10.1128/MCB.05958-11 10.1007/s00109-017-1524-6 10.1016/j.cell.2020.04.004 10.1016/j.mehy.2020.109969 10.1016/j.coph.2009.05.003 10.1002/eji.200425273 10.1093/ehjcvp/pvaa028 10.1111/jcpe.12888 10.1371/journal.pone.0237004 10.1016/j.cell.2020.02.058 10.1002/emmm.201200217 10.1016/j.cell.2020.02.052 10.1016/j.antiviral.2013.09.028 10.3390/biology9080235 10.3109/01902148.2013.808285 10.1186/s12979-020-00192-y 10.1111/odi.13653 10.7554/eLife.05005 10.1038/s41368-020-0074-x 10.1016/j.biopha.2018.12.103 10.3389/fimmu.2019.02867 10.1038/nrm3335 10.3390/ijms21082809 10.1371/journal.pone.0233352 10.1099/vir.0.049528-0 10.1038/s41392-020-00426-x 10.1038/ncomms4729 10.1016/j.cytogfr.2020.06.001 10.1177/0022034520933589 10.2337/db20-0669 10.1152/ajpheart.00068.2005 10.1016/j.cell.2004.12.035 10.1186/s41544-018-0004-7 10.4331/wjbc.v5.i4.437 10.1038/s41569-020-0387-7 10.1055/a-1155-0501 10.1002/iub.2222 10.1016/j.yexcr.2017.01.011 10.1126/science.1260419 |
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| References_xml | – year: 2011 – volume: 39 start-page: 275 issue: 7 year: 2013 end-page: 282 article-title: Upregulation of miR‐146a contributes to the suppression of inflammatory responses in LPS‐induced acute lung injury publication-title: Exp Lung Res – volume: 4 year: 2015 article-title: Predicting effective microRNA target sites in mammalian mRNAs publication-title: Elife – volume: 69 start-page: 2691 issue: 12 year: 2020 end-page: 2699 article-title: Expression of ACE2, the SARS‐CoV‐2 receptor, in lung tissue of patients with Type 2 diabetes publication-title: Diabetes – year: 2020 article-title: Dental diseases are associated with increased odds ratio for coronavirus disease 19 publication-title: Oral Dis – volume: 5 start-page: 283 issue: 1 year: 2020 article-title: CD147‐spike protein is a novel route for SARS‐CoV‐2 infection to host cells publication-title: Signal Transduct Target Ther – volume: 128 year: 2019 article-title: The angiotensin converting enzyme 2/angiotensin‐(1‐7)/Mas Receptor axis as a key player in alveolar bone remodeling publication-title: Bone – volume: 5 start-page: 3729 year: 2014 article-title: Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4 publication-title: Nat Commun – volume: 35 start-page: 243 issue: 1 year: 2005 end-page: 251 article-title: Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3‐kinase‐mediated intracellular signaling publication-title: Eur J Immunol – volume: 181 start-page: 281 issue: 2 year: 2020 end-page: 292.e6 article-title: Structure, function, and antigenicity of the SARS‐CoV‐2 spike glycoprotein publication-title: Cell – volume: 99 start-page: 1120 issue: 10 year: 2020 end-page: 1121 article-title: TMPRSS2 and ACE2 Coexpression in SARS‐CoV‐2 Salivary Glands Infection publication-title: J Dent Res – volume: 347 issue: 6220 year: 2015 article-title: Proteomics. Tissue‐based map of the human proteome publication-title: Science – volume: 94 start-page: 985 issue: Pt 5 year: 2013 end-page: 995 article-title: Host microRNA molecular signatures associated with human H1N1 and H3N2 influenza A viruses reveal an unanticipated antiviral activity for miR‐146a publication-title: J Gen Virol – volume: 144 year: 2020 article-title: Is periodontal disease a risk factor for severe COVID‐19 illness? publication-title: Med Hypotheses – volume: 4 start-page: 412 issue: 5 year: 2012 end-page: 423 article-title: Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharide publication-title: EMBO Mol Med – volume: 32 start-page: 399 issue: 2 year: 2012 end-page: 414 article-title: Integration of regulatory networks by NKX3‐1 promotes androgen‐dependent prostate cancer survival publication-title: Mol Cell Biol – volume: 289 start-page: H1013 issue: 3 year: 2005 end-page: H1019 article-title: Angiotensin II AT1 receptors regulate ACE2 and angiotensin‐(1‐7) expression in the aorta of spontaneously hypertensive rats publication-title: Am J Physiol Heart Circ Physiol – volume: 15 issue: 8 year: 2020 article-title: Salivary microRNA 155, 146a/b and 203: a pilot study for potentially non‐invasive diagnostic biomarkers of periodontitis and diabetes mellitus publication-title: PLoS One – year: 2020 article-title: SARS‐CoV‐2 infection: the role of cytokines in COVID‐19 disease publication-title: Cytokine Growth Factor Rev – volume: 1 start-page: 1 issue: 1 year: 2019 article-title: microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines publication-title: ExRNA – volume: 72 start-page: 343 issue: 3 year: 2020 end-page: 360 article-title: The role of miR‐146a in viral infection publication-title: IUBMB Life – volume: 181 start-page: 905 issue: 4 year: 2020 end-page: 913.e7 article-title: Inhibition of SARS‐CoV‐2 infections in engineered human tissues using clinical‐grade soluble human ACE2 publication-title: Cell – volume: 17 start-page: 21 year: 2020 article-title: SARS‐CoV‐2 disease severity and diabetes: why the connection and what is to be done? publication-title: Immun Ageing – volume: 9 start-page: 514 issue: 4 year: 2009 end-page: 520 article-title: microRNAs and the immune response publication-title: Curr Opin Pharmacol – volume: 181 start-page: 271 issue: 2 year: 2020 end-page: 280.e8 article-title: SARS‐CoV‐2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor publication-title: Cell – volume: 111 start-page: 740 year: 2019 end-page: 750 article-title: Downregulation of miR‐146a inhibits influenza A virus replication by enhancing the type I interferon response in vitro and in vivo publication-title: Biomed Pharmacother – volume: 45 start-page: 663 issue: 6 year: 2018 end-page: 671 article-title: MicroRNA‐146a and microRNA‐155 as novel crevicular fluid biomarkers for periodontitis in non‐diabetic and type 2 diabetic patients publication-title: J Clin Periodontol – volume: 52 start-page: 257 issue: 5 year: 2020 end-page: 263 article-title: The ACE‐2 in COVID‐19: foe or friend? publication-title: Horm Metab Res – volume: 12 start-page: 8 issue: 1 year: 2020 article-title: High expression of ACE2 receptor of 2019‐nCoV on the epithelial cells of oral mucosa publication-title: Int J Oral Sci – volume: 5 start-page: 437 issue: 4 year: 2014 end-page: 456 article-title: Identification of host miRNAs that may limit human rhinovirus replication publication-title: World J Biol Chem – year: 2020 – volume: 120 start-page: 15 issue: 1 year: 2005 end-page: 20 article-title: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets publication-title: Cell – volume: 352 start-page: 184 issue: 2 year: 2017 end-page: 192 article-title: MicroRNA‐146a induction during influenza H3N2 virus infection targets and regulates TRAF6 levels in human nasal epithelial cells (hNECs) publication-title: Exp Cell Res – volume: 9 start-page: 235 issue: 8 year: 2020 article-title: ACE2 protein landscape in the head and neck region: the conundrum of SARS‐CoV‐2 infection publication-title: Biology (Basel) – volume: 6 start-page: 135 issue: 3 year: 2020 end-page: 136 article-title: Neprilysin inhibitor‐angiotensin II receptor blocker combination (sacubitril/valsartan): rationale for adoption in SARS‐CoV‐2 patients publication-title: Eur Heart J Cardiovasc Pharmacother – volume: 10 start-page: 2867 year: 2019 article-title: CLEC2 and CLEC5A: pathogenic host factors in acute viral infections publication-title: Front Immunol – volume: 100 start-page: 605 issue: 3 year: 2013 end-page: 614 article-title: Proteolytic activation of the SARS‐coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research publication-title: Antiviral Res – year: 2020 article-title: A single‐cell RNA expression map of human coronavirus entry factors publication-title: bioRxiv – volume: 21 start-page: 2809 issue: 8 year: 2020 article-title: Salivary small extracellular vesicles associated miRNAs in periodontal status‐A pilot study publication-title: Int J Mol Sci – volume: 13 start-page: 328 issue: 5 year: 2012 end-page: 335 article-title: Intercellular communication: diverse structures for exchange of genetic information publication-title: Nat Rev Mol Cell Biol – volume: 95 start-page: 461 year: 2017 end-page: 463 article-title: The renin‐angiotensin system and prolylcarboxypeptidase publication-title: J Mol Med – volume: 17 start-page: 378 issue: 6 year: 2020 article-title: Mechanisms by which angiotensin‐receptor blockers increase ACE2 levels publication-title: Nat Rev Cardiol – volume: 15 issue: 5 year: 2020 article-title: Airway mir‐155 responses are associated with TH1 cytokine polarization in young children with viral respiratory infections publication-title: PLoS One – ident: e_1_2_7_29_1 doi: 10.1016/j.bone.2019.115041 – ident: e_1_2_7_31_1 doi: 10.1128/MCB.05958-11 – ident: e_1_2_7_24_1 doi: 10.1007/s00109-017-1524-6 – ident: e_1_2_7_32_1 doi: 10.1016/j.cell.2020.04.004 – ident: e_1_2_7_5_1 doi: 10.1016/j.mehy.2020.109969 – ident: e_1_2_7_7_1 doi: 10.1016/j.coph.2009.05.003 – ident: e_1_2_7_35_1 doi: 10.1002/eji.200425273 – ident: e_1_2_7_40_1 doi: 10.1093/ehjcvp/pvaa028 – ident: e_1_2_7_9_1 doi: 10.1111/jcpe.12888 – ident: e_1_2_7_10_1 doi: 10.1371/journal.pone.0237004 – ident: e_1_2_7_15_1 doi: 10.1016/j.cell.2020.02.058 – ident: e_1_2_7_30_1 doi: 10.1002/emmm.201200217 – ident: e_1_2_7_14_1 doi: 10.1016/j.cell.2020.02.052 – ident: e_1_2_7_17_1 doi: 10.1016/j.antiviral.2013.09.028 – ident: e_1_2_7_23_1 doi: 10.3390/biology9080235 – ident: e_1_2_7_37_1 doi: 10.3109/01902148.2013.808285 – ident: e_1_2_7_3_1 doi: 10.1186/s12979-020-00192-y – ident: e_1_2_7_4_1 doi: 10.1111/odi.13653 – ident: e_1_2_7_20_1 doi: 10.7554/eLife.05005 – year: 2020 ident: e_1_2_7_13_1 article-title: A single‐cell RNA expression map of human coronavirus entry factors publication-title: bioRxiv – ident: e_1_2_7_22_1 doi: 10.1038/s41368-020-0074-x – ident: e_1_2_7_42_1 doi: 10.1016/j.biopha.2018.12.103 – ident: e_1_2_7_33_1 doi: 10.3389/fimmu.2019.02867 – ident: e_1_2_7_12_1 doi: 10.1038/nrm3335 – ident: e_1_2_7_11_1 doi: 10.3390/ijms21082809 – ident: e_1_2_7_38_1 doi: 10.1371/journal.pone.0233352 – ident: e_1_2_7_43_1 doi: 10.1099/vir.0.049528-0 – ident: e_1_2_7_16_1 doi: 10.1038/s41392-020-00426-x – ident: e_1_2_7_27_1 – ident: e_1_2_7_34_1 doi: 10.1038/ncomms4729 – ident: e_1_2_7_2_1 doi: 10.1016/j.cytogfr.2020.06.001 – ident: e_1_2_7_21_1 doi: 10.1177/0022034520933589 – volume-title: Implications of the virus‐encoded miRNA and host miRNA in the pathogenicity of SARS‐CoV‐2 year: 2020 ident: e_1_2_7_8_1 – ident: e_1_2_7_28_1 doi: 10.2337/db20-0669 – ident: e_1_2_7_26_1 doi: 10.1152/ajpheart.00068.2005 – ident: e_1_2_7_19_1 doi: 10.1016/j.cell.2004.12.035 – ident: e_1_2_7_6_1 doi: 10.1186/s41544-018-0004-7 – ident: e_1_2_7_41_1 doi: 10.4331/wjbc.v5.i4.437 – ident: e_1_2_7_25_1 doi: 10.1038/s41569-020-0387-7 – ident: e_1_2_7_39_1 doi: 10.1055/a-1155-0501 – ident: e_1_2_7_36_1 doi: 10.1002/iub.2222 – ident: e_1_2_7_44_1 doi: 10.1016/j.yexcr.2017.01.011 – ident: e_1_2_7_18_1 doi: 10.1126/science.1260419 |
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Type 2 diabetes and periodontitis predispose to a higher risk of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Recent... Type 2 diabetes and periodontitis predispose to a higher risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recent studies show... |
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| Title | microRNA‐146a and ‐155, upregulated by periodontitis and type 2 diabetes in oral fluids, are predicted to regulate SARS‐CoV‐2 oral receptor genes |
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