Multi-scale simulations of MUT-16 scaffold protein phase separation and client recognition

Phase separation of proteins plays a critical role in cellular organization. How phase-separated protein condensates underpin biological function and how condensates achieve specificity remain elusive. We investigated the phase separation of MUT-16, a scaffold protein in Mutator foci, and its role i...

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Veröffentlicht in:	Biophysical journal Jg. 124; H. 22; S. 3987
Hauptverfasser:	Gaurav, Kumar, Busetto, Virginia, Páez-Moscoso, Diego Javier, Changiarath, Arya, Hanson, Sonya M, Falk, Sebastian, Ketting, René F, Stelzl, Lukas S
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 18.11.2025
Schlagworte:	Animals Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - chemistry Caenorhabditis elegans Proteins - metabolism Molecular Dynamics Simulation Phase Separation Protein Binding
ISSN:	1542-0086, 1542-0086
Online-Zugang:	Weitere Angaben
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