Meningoencephalitis Due to HIV Replication Despite Plasmatic Viral Control

We report a symptomatic case of HIV replication in CSF (Cerebro Spinal Fluid) despite low plasmatic viral load. The patient, known HIV positive since 3 years, under HAART (Highly Active Antiretroviral therapy), presented an acute meningoencephalitis which was improved by optimization of treatment fo...

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Veröffentlicht in:Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Jg. 10; H. 6; S. 345 - 348
Hauptverfasser: Dinh, Aurélien, Salomon, Jérôme, Du, Damien Le, Mathez, Dominique, Carlier, Robert, Bernard, Louis, Truchis, Pierre de
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States SAGE PUBLICATIONS, INC 01.11.2011
Schlagworte:
Anti-HIV Agents - therapeutic use
Antiretroviral drugs
Antiretroviral therapy
Antiretroviral Therapy, Highly Active
Central nervous system
Drug therapy
Encephalitis
HIV
HIV Infections - drug therapy
HIV-1
Human immunodeficiency virus
Humans
Medical treatment
Meningitis
Meningoencephalitis
Nervous system
Optimization
Penetration
Prescription drugs
Reproducibility
Therapy
Viral Load
ISSN:2325-9574, 1557-0886, 1557-0886, 2325-9582
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Zusammenfassung:We report a symptomatic case of HIV replication in CSF (Cerebro Spinal Fluid) despite low plasmatic viral load. The patient, known HIV positive since 3 years, under HAART (Highly Active Antiretroviral therapy), presented an acute meningoencephalitis which was improved by optimization of treatment for a better CNS (Central Nervous System) penetration according to the CHARTER's (CNS HIV Antiretroviral Therapy Effects Research) score. CNS can be considered as a specific compartment for HIV replication and can be involved in acute or chronic neurologic impairment. As showed in this observation, CHARTER score could be helpful to optimize HAART penetration in CNS, but indication and use remain uncertain in current practice.
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ISSN:2325-9574
1557-0886
1557-0886
2325-9582
DOI:10.1177/1545109711402085