The composition, microstructure, interaction with polysaccharides of casein micelles and their potential application as drug delivery-a review

The majority of milk protein is contained in the particles known as casein micelles, which play a key role in the stability, physico-chemical properties and nutrient value of milk, and these nanoparticles also have various functionalities including emulsification and drug-carrier, due to their uniqu...

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Vydáno v:Food bioscience Ročník 65; s. 106068
Hlavní autoři: Wang, Qian, Liu, Yaoqin, Ma, Ying, Lu, Yu, Huang, Linjuan, Wang, Zhongfu
Médium: Journal Article
Jazyk:angličtina
Vydáno: Elsevier Ltd 01.03.2025
Témata:
acidification
bioactive compounds
bioavailability
calcium phosphates
casein
Casein micelle-polysaccharide complexes
Casein micelles
Drug delivery
drugs
emulsifying
hydrophilicity
hydrophobicity
micelles
Microstructure
milk
Milk protein
nanoparticles
nutritive value
polysaccharides
species
Milk protein
Drug delivery
Microstructure
Casein micelles
Casein micelle-polysaccharide complexes
ISSN:2212-4292
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Shrnutí:The majority of milk protein is contained in the particles known as casein micelles, which play a key role in the stability, physico-chemical properties and nutrient value of milk, and these nanoparticles also have various functionalities including emulsification and drug-carrier, due to their unique structural properties. This work summarizes the current understanding of the structural properties of casein micelles related to their delivery functionality. Casein micelles are natural colloidal nanoparticles in milk composing by four species of caseins (αs1, αs2-, β- and κ-casein) and amorphous calcium phosphate salts. They possess hydrophobic and hydrophilic properties that make them have potential as drug carriers in food, pharmaceutical and cosmetic fields, and the use of micellar structure to encapsulate and delivery bioactive components enhances their stability and bioavailability. In addition, a complexing of casein micelles with polysaccharides mediated by acidification or Millard reaction causes variations in their structure, stability and physico-chemical properties. The casein micelle-polysaccharide complexes are regarded as emerging novel carriers for bioactives with a higher loading efficiency and a more controlled release. [Display omitted] •A current understanding on the structural properties of casein micelles was provided.•The unique structural properties of casein micelles give them potential application in drug delivery.•A complexing of casein micelles with polysaccharides modifies their structure, stability and delivery function.•The complexes of casein micelles and polysaccharides are also emerging novel drug carriers.
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ISSN:2212-4292
DOI:10.1016/j.fbio.2025.106068