Stabilizer-Guided Inhibition of Protein-Protein Interactions

The discovery of novel protein–protein interaction (PPI) modulators represents one of the great molecular challenges of the modern era. PPIs can be modulated by either inhibitor or stabilizer compounds, which target different though proximal regions of the protein interface. In principle, protein–st...

Full description

Saved in:

Bibliographic Details
Published in:	Angewandte Chemie Vol. 127; no. 52; pp. 15946 - 15950
Main Authors:	Milroy, Lech-Gustav, Bartel, Maria, Henen, Morkos A., Leysen, Seppe, Adriaans, Joris M. C., Brunsveld, Luc, Landrieu, Isabelle, Ottmann, Christian
Format:	Journal Article
Language:	English German
Published:	Weinheim WILEY-VCH Verlag 21.12.2015 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Subjects:	Adapter proteins Adapters Alzheimer's disease Binding Chemistry Crystallography Inhibitors Magnetic resonance spectroscopy Modulators Neurodegenerative diseases NMR NMR spectroscopy Nuclear magnetic resonance Peptidinhibitoren Protein interaction Protein-Protein-Wechselwirkungen Proteins Strukturgeleitetes Design Tau protein Therapeutic targets Vices Wirkstoff-Forschung X-rays
ISSN:	0044-8249, 1521-3757
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!