Complement Component C3 Variant (R102G) and the Risk of Neovascular Age-Related Macular Degeneration in a Tunisian Population

To explore the association between the polymorphism (S/F) p.R102G in the C3 gene and age-related macular degeneration (AMD) in a Tunisian population. The molecular study was performed by polymerase chain reaction using sequence-specific primers (PCR-SSP) in 207 control subjects free of any eye disea...

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Veröffentlicht in:Klinische Monatsblatter fur Augenheilkunde Jg. 234; H. 4; S. 478
Hauptverfasser: Habibi, Imen, Sfar, Imen, Kort, Fedra, Bouraoui, Rim, Chebil, Ahmed, Limaiem, Rim, Ayed, Saloua, Ben Abdallah, Taïeb, El Matri, Leila, Gorgi, Yousr
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Germany 01.04.2017
Schlagworte:
Aged
Aged, 80 and over
Complement C3 - genetics
Female
Genetic Association Studies
Genetic Markers - genetics
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
Humans
Incidence
Macular Degeneration - diagnosis
Macular Degeneration - epidemiology
Macular Degeneration - genetics
Male
Middle Aged
Mutation - genetics
Polymorphism, Single Nucleotide - genetics
Reproducibility of Results
Risk Assessment - methods
Sensitivity and Specificity
Tunisia - epidemiology
ISSN:1439-3999, 1439-3999
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Zusammenfassung:To explore the association between the polymorphism (S/F) p.R102G in the C3 gene and age-related macular degeneration (AMD) in a Tunisian population. The molecular study was performed by polymerase chain reaction using sequence-specific primers (PCR-SSP) in 207 control subjects free of any eye disease (fundus normal) and 145 patients with exudative AMD. The activity and quantification of and have been made by technical home method and nephelometry, respectively. The prevalence of GG genotype polymorphism was significantly higher in AMD patients compared to controls (OR: 2.41, IC 95% [1.90-3.05], p = 0.0007). However, no correlation was found between this allelic variant and the type of neovascularization. Similarly, there is no association between this polymorphism and the presence of functional and/or quantitative hypocomplementemia. The GG genotype of the gene could be a susceptibility factor for AMD in the Tunisian population. However, it does not seem to influence the clinical profile of the disease.
Bibliographie:ObjectType-Article-1
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ISSN:1439-3999
1439-3999
DOI:10.1055/s-0043-104419