Assessment of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant radiotherapy Quality assessment within a randomized phase III trial testing a cardioprotective treatment strategy (SAFE-2014)
Background and purpose In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related t...
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| Vydáno v: | Strahlentherapie und Onkologie Ročník 195; číslo 1; s. 43 - 51 |
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| Hlavní autoři: | , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Berlin/Heidelberg
Springer Berlin Heidelberg
01.01.2019
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| Témata: | |
| ISSN: | 0179-7158, 1439-099X, 1439-099X |
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| Abstract | Background and purpose
In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made.
Patients and methods
Heart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD.
Results
Mean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97.
Conclusion
Results showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial. |
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| AbstractList | In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made.BACKGROUND AND PURPOSEIn our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made.Heart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD.PATIENTS AND METHODSHeart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD.Mean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97.RESULTSMean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97.Results showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial.CONCLUSIONResults showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial. Background and purpose In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made. Patients and methods Heart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD. Results Mean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97. Conclusion Results showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial. In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made. Heart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD. Mean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97. Results showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial. |
| Author | Calusi, Silvia Becherini, Carlotta Livi, Lorenzo Loi, Mauro Terziani, Francesca Olmetto, Emanuela Delli Paoli, Camilla Bonomo, Pierluigi Casati, Marta Desideri, Isacco Greto, Daniela Pallotta, Stefania Francolini, Giulio Meattini, Icro Pezzulla, Donato |
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| CitedBy_id | crossref_primary_10_3389_fcvm_2020_00016 crossref_primary_10_3389_fonc_2020_01708 crossref_primary_10_1016_j_ijrobp_2022_11_021 crossref_primary_10_1007_s00432_021_03875_1 crossref_primary_10_2478_raon_2020_0050 |
| Cites_doi | 10.1016/j.ijrobp.2009.04.093 10.1016/j.radonc.2017.01.008 10.1016/j.ijrobp.2017.05.030 10.1016/j.clon.2010.05.006 10.1186/s13014-016-0627-5 10.1007/s12032-017-0938-x 10.1016/j.radonc.2016.04.041 10.1016/j.ijrobp.2008.10.034 10.1016/j.radonc.2013.06.025 10.1056/NEJMoa1209825 10.1016/j.ijrobp.2009.10.058 10.1016/j.jacc.2010.11.063 10.1109/42.363096 10.1007/s11548-015-1266-2 10.3109/0284186X.2013.813069 |
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| Keywords | Anthracyclines Anthrazykline Ramipril Kardiovaskuläre Erkrankungen Bisoprolol Cardiovascular diseases Trastuzumab |
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| Snippet | Background and purpose
In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular... In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014,... In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014,... |
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| SubjectTerms | Algorithms Bisoprolol - administration & dosage Cardiotonic Agents - administration & dosage Chemotherapy, Adjuvant - methods Combined Modality Therapy - methods Drug Therapy, Combination Echocardiography, Doppler - methods Female Guideline Adherence Heart - drug effects Heart - radiation effects Humans Medicine Medicine & Public Health Observer Variation Oncology Original Article Quality Assurance, Health Care Radiation Injuries - diagnostic imaging Radiation Injuries - prevention & control Radiometry - methods Radiotherapy Radiotherapy, Adjuvant - methods Ramipril - administration & dosage Reproducibility of Results Unilateral Breast Neoplasms - drug therapy Unilateral Breast Neoplasms - radiotherapy |
| Subtitle | Quality assessment within a randomized phase III trial testing a cardioprotective treatment strategy (SAFE-2014) |
| Title | Assessment of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant radiotherapy |
| URI | https://link.springer.com/article/10.1007/s00066-018-1388-x https://www.ncbi.nlm.nih.gov/pubmed/30406290 https://www.proquest.com/docview/2131233168 |
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