Effects of ABCG2 421C > A genetic polymorphism on the pharmacokinetics of rivaroxaban in healthy Chinese subjects

The main objective of this study is to investigate whether the CYP3A4/5 and ABC transporter genetic polymorphisms could affect the pharmacokinetics (PK) of rivaroxaban in Chinese healthy subjects.Forty-two healthy subjects in China were recruited and given a single dose of 2.5 mg rivaroxaban tablets...

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Bibliographic Details
Published in:	Xenobiotica Vol. 55; no. 6; pp. 445 - 453
Main Authors:	Guo, Lingfang, Sun, Xue, Bo, Qiu, Bai, Wanjun, Du, Yabin, Song, Haojing
Format:	Journal Article
Language:	English
Published:	England 03.07.2025
Subjects:	Adult ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism China East Asian People - genetics Female Genotype Healthy Volunteers Humans Male Multidrug Resistance-Associated Protein 2 Neoplasm Proteins - genetics Polymorphism, Genetic Polymorphism, Single Nucleotide - genetics Rivaroxaban - pharmacokinetics China ABCG2 421C > A pharmacokinetics Rivaroxaban genetic polymorphism
ISSN:	0049-8254, 1366-5928, 1366-5928
Online Access:	Get full text
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