Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models

DNA polymerase theta (Polθ, encoded by the POLQ gene) is a DNA repair enzyme critical for microhomology mediated end joining (MMEJ). Polθ has limited expression in normal tissues but is frequently overexpressed in cancer cells and, therefore, represents an ideal target for tumor-specific radiosensit...

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Vydané v:	Clinical cancer research Ročník 29; číslo 8; s. 1631
Hlavní autori:	Rodriguez-Berriguete, Gonzalo, Ranzani, Marco, Prevo, Remko, Puliyadi, Rathi, Machado, Nicole, Bolland, Hannah R, Millar, Val, Ebner, Daniel, Boursier, Marie, Cerutti, Aurora, Cicconi, Alessandro, Galbiati, Alessandro, Grande, Diego, Grinkevich, Vera, Majithiya, Jayesh B, Piscitello, Desiree, Rajendra, Eeson, Stockley, Martin L, Boulton, Simon J, Hammond, Ester M, Heald, Robert A, Smith, Graeme C M, Robinson, Helen M R, Higgins, Geoff S
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 14.04.2023
Predmet:	Cell Line, Tumor Humans Neoplasms - drug therapy Neoplasms - genetics Neoplasms - radiotherapy
ISSN:	1557-3265, 1557-3265
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