Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models

DNA polymerase theta (Polθ, encoded by the POLQ gene) is a DNA repair enzyme critical for microhomology mediated end joining (MMEJ). Polθ has limited expression in normal tissues but is frequently overexpressed in cancer cells and, therefore, represents an ideal target for tumor-specific radiosensit...

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Bibliographic Details

Published in:	Clinical cancer research Vol. 29; no. 8; p. 1631
Main Authors:	Rodriguez-Berriguete, Gonzalo, Ranzani, Marco, Prevo, Remko, Puliyadi, Rathi, Machado, Nicole, Bolland, Hannah R, Millar, Val, Ebner, Daniel, Boursier, Marie, Cerutti, Aurora, Cicconi, Alessandro, Galbiati, Alessandro, Grande, Diego, Grinkevich, Vera, Majithiya, Jayesh B, Piscitello, Desiree, Rajendra, Eeson, Stockley, Martin L, Boulton, Simon J, Hammond, Ester M, Heald, Robert A, Smith, Graeme C M, Robinson, Helen M R, Higgins, Geoff S
Format:	Journal Article
Language:	English
Published:	United States 14.04.2023
Subjects:	Cell Line, Tumor Humans Neoplasms - drug therapy Neoplasms - genetics Neoplasms - radiotherapy
ISSN:	1557-3265, 1557-3265
Online Access:	Get more information
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