Transcriptional state and function of CD8 + memory T cells is linked to past proliferation

A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells. Importantly, the extent of past proliferation was related to distinct transcriptional features and re-expansion potential, highlighting an unappreciated...

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Vydané v:	Nature immunology Ročník 23; číslo 5; s. 658 - 659
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Nature Publishing Group 01.05.2022
Predmet:	CD8 antigen Cell cycle Cell growth Cell proliferation Division of labor Genetic engineering Heterogeneity Immunological memory Immunology Infections Lymphocytes Lymphocytes T Memory cells Population Stem cells
ISSN:	1529-2908, 1529-2916, 1529-2916
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