Programmable models of growth and mutation of cancer-cell populations
In this paper we propose a systematic approach to construct mathematical models describing populations of cancer-cells at different stages of disease development. The methodology we propose is based on stochastic Concurrent Constraint Programming, a flexible stochastic modelling language. The methodo...
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| Vydané v: | Electronic proceedings in theoretical computer science Ročník 67; číslo Proc. CompMod 2011; s. 19 - 33 |
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| Hlavní autori: | , |
| Médium: | Journal Article |
| Jazyk: | English |
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10.09.2011
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| ISSN: | 2075-2180, 2075-2180 |
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| Abstract | In this paper we propose a systematic approach to construct mathematical models describing populations of cancer-cells at different stages of disease development. The methodology we propose is based on stochastic Concurrent Constraint Programming, a flexible stochastic modelling language. The methodology is tested on (and partially motivated by) the study of prostate cancer. In particular, we prove how our method is suitable to systematically reconstruct different mathematical models of prostate cancer growth --together with interactions with different kinds of hormone therapy-- at different levels of refinement. |
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| AbstractList | In this paper we propose a systematic approach to construct mathematical models describing populations of cancer-cells at different stages of disease development. The methodology we propose is based on stochastic Concurrent Constraint Programming, a flexible stochastic modelling language. The methodology is tested on (and partially motivated by) the study of prostate cancer. In particular, we prove how our method is suitable to systematically reconstruct different mathematical models of prostate cancer growth --together with interactions with different kinds of hormone therapy-- at different levels of refinement. |
| Author | Bortolussi, Luca Policriti, Alberto |
| Author_xml | – sequence: 1 givenname: Luca surname: Bortolussi fullname: Bortolussi, Luca organization: Dept. of Mathematics and Informatics, University of Trieste, Italy – sequence: 2 givenname: Alberto surname: Policriti fullname: Policriti, Alberto organization: Dept. of Mathematics and Informatics, University of Udine, Italy. Institute of Applied Genomics, Udine, Italy |
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| Cites_doi | 10.1007/s00332-008-9031-0 10.1016/j.ijar.2009.06.007 10.1201/9781420010664 10.1016/S0304-3975(97)00127-8 10.1063/1.481811 10.1007/978-3-642-04186-0_3 10.1109/UKSIM.2011.24 10.1007/978-3-642-03845-7_15 10.1016/j.tcs.2010.02.008 10.1016/S0304-3975(00)00305-4 10.1007/978-3-642-04186-0_11 10.4204/EPTCS.6.5 10.1016/j.tcs.2009.02.037 10.1007/978-1-4899-4483-2 10.1016/j.eururo.2009.07.049 10.3934/dcdsb.2004.4.187 10.1021/j100540a008 10.1111/j.1464-410X.2007.07138.x 10.1098/rsta.2010.0221 10.1017/CBO9780511810633 10.1007/s10601-007-9034-8 10.1007/978-3-540-68894-5_8 10.1016/j.entcs.2008.12.108 |
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Notes Theor. Comput. Sci. doi: 10.1016/j.entcs.2008.12.108 |
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