Verification and Establishment of Reference Intervals for Prothrombin Time and Activated Partial Thromboplastin Time for Children in a Clinical Laboratory

Prothrombin time (PT) and activated partial thromboplastin time (aPTT) are routine coagulation tests. The absence of age-dependent reference interval (RI) may lead to abnormal results in children. In this study, we aimed to verify adult-based RIs in children and establish pediatric RIs for PT and aP...

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Bibliographic Details
Published in:Clinical laboratory (Heidelberg) Vol. 68; no. 2
Main Authors: Lee, Min Young, Lee, Woo In, Kang, So Young, Kim, Myeong Hee
Format: Journal Article
Language:English
Published: Germany 01.01.2022
Subjects:
Adolescent
Adult
Blood Coagulation Tests
Child
Child, Preschool
Humans
Infant
Laboratories, Clinical
Partial Thromboplastin Time
Prothrombin Time
Reference Values
ISSN:1433-6510
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Summary:Prothrombin time (PT) and activated partial thromboplastin time (aPTT) are routine coagulation tests. The absence of age-dependent reference interval (RI) may lead to abnormal results in children. In this study, we aimed to verify adult-based RIs in children and establish pediatric RIs for PT and aPTT. We analyzed PT and aPTT results. Samples from inpatients and outpatients aged 1 - 18 years, considered healthy subjects, were divided into six groups by age. Verification and establishment of RIs were conducted. Applying adult-based RIs to pediatrics was statistically invalid for individuals aged 10 - 18 years for PT and invalid throughout childhood for aPTT. The new RI of PT for individuals aged 10 - 18 years was 11.1 - 14.1 seconds and that of aPTT for individuals aged 1 - 9 years was 28.2 - 46.0 seconds. Pediatric RIs were higher than adult-based RIs. Using pediatric RI can save time, labor, and costs to make clinical decision.
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ISSN:1433-6510
DOI:10.7754/Clin.Lab.2021.210539