Associations between biological age acceleration and hospitalization burden of community-acquired pneumonia: a cohort study
Community-acquired pneumonia (CAP) is a leading infectious cause of death, particularly in the elderly. Although biological age (BA) acceleration is a major risk factor for age-related diseases, its role in infectious diseases such as CAP remains unclear. This study investigated the association betw...
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16.11.2025
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| Abstract | Community-acquired pneumonia (CAP) is a leading infectious cause of death, particularly in the elderly. Although biological age (BA) acceleration is a major risk factor for age-related diseases, its role in infectious diseases such as CAP remains unclear. This study investigated the association between BA acceleration and CAP hospitalization and mortality. We analyzed data from 47,181 participants in the Shanghai Suburban Adult Cohort and Biobank. BA was estimated using the Klemera-Doubal (KDMAge), Phenotypic age (PhenoAge), and homeostatic dysregulation (HD) methods, with validation of the customized BA algorithms. BA acceleration was calculated as residuals from regressing BA on chronological age. We performed time-dependent Cox regression (Andersen-Gill model) to assess associations with CAP outcomes, and generalized linear models to evaluate length of stay (LOS). The average KDMAge acceleration, PhenoAge acceleration, and log(HDAge) at baseline were 1.29 ± 5.80, -0.94 ± 4.28, and 4.18 ± 0.01 years, respectively. Each 1 standard deviation (SD) increase in KDMAge acceleration was associated with a 7% (95% CI: 1, 15%) higher CAP hospitalization risk and a 56% (95% CI: 23, 97%) higher risk of CAP-related mortality. Similar associations were observed for PhenoAge and log(HDAge). Prolonged LOS was associated with PhenoAge acceleration and log(HDAge). Risks were especially elevated among those aged ≥ 60 and males, with greater susceptibility at equivalent BA acceleration levels. Accelerated BA is associated with CAP hospitalization and related deaths, especially among males and the elderly. These findings suggest that BA may help identify individuals at higher CAP risk, offering potential for early intervention. |
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| AbstractList | Community-acquired pneumonia (CAP) is a leading infectious cause of death, particularly in the elderly. Although biological age (BA) acceleration is a major risk factor for age-related diseases, its role in infectious diseases such as CAP remains unclear. This study investigated the association between BA acceleration and CAP hospitalization and mortality. We analyzed data from 47,181 participants in the Shanghai Suburban Adult Cohort and Biobank. BA was estimated using the Klemera-Doubal (KDMAge), Phenotypic age (PhenoAge), and homeostatic dysregulation (HD) methods, with validation of the customized BA algorithms. BA acceleration was calculated as residuals from regressing BA on chronological age. We performed time-dependent Cox regression (Andersen-Gill model) to assess associations with CAP outcomes, and generalized linear models to evaluate length of stay (LOS). The average KDMAge acceleration, PhenoAge acceleration, and log(HDAge) at baseline were 1.29 ± 5.80, -0.94 ± 4.28, and 4.18 ± 0.01 years, respectively. Each 1 standard deviation (SD) increase in KDMAge acceleration was associated with a 7% (95% CI: 1, 15%) higher CAP hospitalization risk and a 56% (95% CI: 23, 97%) higher risk of CAP-related mortality. Similar associations were observed for PhenoAge and log(HDAge). Prolonged LOS was associated with PhenoAge acceleration and log(HDAge). Risks were especially elevated among those aged ≥ 60 and males, with greater susceptibility at equivalent BA acceleration levels. Accelerated BA is associated with CAP hospitalization and related deaths, especially among males and the elderly. These findings suggest that BA may help identify individuals at higher CAP risk, offering potential for early intervention.Community-acquired pneumonia (CAP) is a leading infectious cause of death, particularly in the elderly. Although biological age (BA) acceleration is a major risk factor for age-related diseases, its role in infectious diseases such as CAP remains unclear. This study investigated the association between BA acceleration and CAP hospitalization and mortality. We analyzed data from 47,181 participants in the Shanghai Suburban Adult Cohort and Biobank. BA was estimated using the Klemera-Doubal (KDMAge), Phenotypic age (PhenoAge), and homeostatic dysregulation (HD) methods, with validation of the customized BA algorithms. BA acceleration was calculated as residuals from regressing BA on chronological age. We performed time-dependent Cox regression (Andersen-Gill model) to assess associations with CAP outcomes, and generalized linear models to evaluate length of stay (LOS). The average KDMAge acceleration, PhenoAge acceleration, and log(HDAge) at baseline were 1.29 ± 5.80, -0.94 ± 4.28, and 4.18 ± 0.01 years, respectively. Each 1 standard deviation (SD) increase in KDMAge acceleration was associated with a 7% (95% CI: 1, 15%) higher CAP hospitalization risk and a 56% (95% CI: 23, 97%) higher risk of CAP-related mortality. Similar associations were observed for PhenoAge and log(HDAge). Prolonged LOS was associated with PhenoAge acceleration and log(HDAge). Risks were especially elevated among those aged ≥ 60 and males, with greater susceptibility at equivalent BA acceleration levels. Accelerated BA is associated with CAP hospitalization and related deaths, especially among males and the elderly. These findings suggest that BA may help identify individuals at higher CAP risk, offering potential for early intervention. Community-acquired pneumonia (CAP) is a leading infectious cause of death, particularly in the elderly. Although biological age (BA) acceleration is a major risk factor for age-related diseases, its role in infectious diseases such as CAP remains unclear. This study investigated the association between BA acceleration and CAP hospitalization and mortality. We analyzed data from 47,181 participants in the Shanghai Suburban Adult Cohort and Biobank. BA was estimated using the Klemera-Doubal (KDMAge), Phenotypic age (PhenoAge), and homeostatic dysregulation (HD) methods, with validation of the customized BA algorithms. BA acceleration was calculated as residuals from regressing BA on chronological age. We performed time-dependent Cox regression (Andersen-Gill model) to assess associations with CAP outcomes, and generalized linear models to evaluate length of stay (LOS). The average KDMAge acceleration, PhenoAge acceleration, and log(HDAge) at baseline were 1.29 ± 5.80, -0.94 ± 4.28, and 4.18 ± 0.01 years, respectively. Each 1 standard deviation (SD) increase in KDMAge acceleration was associated with a 7% (95% CI: 1, 15%) higher CAP hospitalization risk and a 56% (95% CI: 23, 97%) higher risk of CAP-related mortality. Similar associations were observed for PhenoAge and log(HDAge). Prolonged LOS was associated with PhenoAge acceleration and log(HDAge). Risks were especially elevated among those aged ≥ 60 and males, with greater susceptibility at equivalent BA acceleration levels. Accelerated BA is associated with CAP hospitalization and related deaths, especially among males and the elderly. These findings suggest that BA may help identify individuals at higher CAP risk, offering potential for early intervention. |
| Author | Qian, Chen Yi, Liping Yu, Hongjie Jiang, Yonggen Zhang, Youyi Liu, Xiaohua Zhao, Genming Wang, Biying Zhang, Tao |
| Author_xml | – sequence: 1 givenname: Biying surname: Wang fullname: Wang, Biying – sequence: 2 givenname: Chen surname: Qian fullname: Qian, Chen – sequence: 3 givenname: Liping surname: Yi fullname: Yi, Liping – sequence: 4 givenname: Youyi surname: Zhang fullname: Zhang, Youyi – sequence: 5 givenname: Hongjie surname: Yu fullname: Yu, Hongjie – sequence: 6 givenname: Xiaohua surname: Liu fullname: Liu, Xiaohua – sequence: 7 givenname: Yonggen surname: Jiang fullname: Jiang, Yonggen – sequence: 8 givenname: Tao surname: Zhang fullname: Zhang, Tao – sequence: 9 givenname: Genming surname: Zhao fullname: Zhao, Genming |
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| Cites_doi | 10.1016/j.mad.2013.01.004 10.1007/s00420-022-01848-6 10.3389/fimmu.2023.1146704 10.7554/eLife.63425 10.1016/j.archger.2024.105477 10.1111/1469-0691.12717 10.1038/s41467-024-50760-9 10.1056/NEJMra2301292 10.1111/psyp.14205 10.1038/s42255-023-00758-2 10.1371/journal.pmed.1002718 10.1101/2020.07.10.20147777 10.1093/gerona/gls233 10.18632/aging.101352 10.1016/j.exger.2016.12.021 10.46234/ccdcw2024.069 10.1001/jama.294.21.2712 10.1038/s41586-021-03547-7 10.1056/NEJMoa1500245 10.3390/cancers13205041 10.1111/jgs.12773 10.1016/S0140-6736(21)00630-9 10.1007/s40520-023-02607-4 10.1002/sim.2165 10.1016/S2666-7568(23)00220-9 10.1136/bmjopen-2019-035430 10.1038/s41467-022-34487-z 10.7554/eLife.51507 10.1038/s41598-021-86854-3 10.1007/s41999-024-00974-3 10.1016/S0140-6736(18)32203-7 10.1038/s41591-023-02296-6 10.1016/j.ebiom.2023.104458 10.1016/j.amjmed.2020.07.022 10.2307/2344614 10.3390/pathogens14010041 10.1016/j.mad.2005.10.004 10.1093/cid/ciac397 10.1093/ageing/afx162 10.1016/j.diabres.2025.112213 |
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| Keywords | Biological age CAP Mortality Blood biomarkers Physical measurements |
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| References | Z Liu (1995_CR14) 2019; 15 Q Zhao (1995_CR17) 2020; 10 A Häder (1995_CR7) 2023; 14 H Wang (1995_CR11) 2024; 124 EH Gordon (1995_CR32) 2017; 89 S Aliberti (1995_CR4) 2021; 398 M van der Heiden (1995_CR9) 2024; 15 K Toren (1995_CR37) 2022; 95 Y Hu (1995_CR2) 2022; 22 SS Bae (1995_CR42) 2021; 134 MJ Yousefzadeh (1995_CR6) 2021; 594 L Chen (1995_CR30) 2023; 89 A Grifoni (1995_CR5) 2023; 14 P Klemera (1995_CR13) 2006; 127 K Iwai-Saito (1995_CR26) 2021; 11 JR Shapiro (1995_CR39) 2022; 75 S Jain (1995_CR24) 2015; 373 LA van Vught (1995_CR8) 2014; 20 Y Xie (1995_CR18) 2024; 6 JA Nelder (1995_CR23) 1972; 135 G Kojima (1995_CR28) 2018; 47 AM Fry (1995_CR3) 2005; 294 AA Cohen (1995_CR15) 2013; 134 Y Yang (1995_CR27) 2024; 15 N Kang (1995_CR38) 2025 BT Yazar (1995_CR41) 2025; 224 S Hagg (1995_CR34) 2021 1995_CR16 P Riese (1995_CR10) 2022; 13 GBD 2017 Causes of Death Collaborators (1995_CR1) 2018; 392 DH Kim (1995_CR25) 2024; 391 YE Tian (1995_CR12) 2023; 29 Y Liang (1995_CR29) 2023; 35 L Chen (1995_CR31) 2024; 5 RJ Cook (1995_CR22) 2007 M Jiang (1995_CR33) 2017; 9 B Jabłońska (1995_CR40) 2021; 13 C Kuehnemann (1995_CR43) 2023; 5 MD Tobin (1995_CR19) 2005; 24 O Theou (1995_CR35) 2014; 62 R Beijers (1995_CR36) 2023; 60 ME Levine (1995_CR20) 2013; 68 X Li (1995_CR21) 2020 |
| References_xml | – volume-title: The statistical analysis of recurrent events year: 2007 ident: 1995_CR22 – volume: 134 start-page: 110 issue: 3 year: 2013 ident: 1995_CR15 publication-title: Mech Ageing Dev doi: 10.1016/j.mad.2013.01.004 – volume: 95 start-page: 1797 issue: 8 year: 2022 ident: 1995_CR37 publication-title: Int Arch Occup Environ Health doi: 10.1007/s00420-022-01848-6 – volume: 14 year: 2023 ident: 1995_CR5 publication-title: Front Immunol doi: 10.3389/fimmu.2023.1146704 – year: 2021 ident: 1995_CR34 publication-title: Elife doi: 10.7554/eLife.63425 – volume: 124 year: 2024 ident: 1995_CR11 publication-title: Arch Gerontol Geriatr doi: 10.1016/j.archger.2024.105477 – volume: 20 start-page: 1183 issue: 11 year: 2014 ident: 1995_CR8 publication-title: Clin Microbiol Infect doi: 10.1111/1469-0691.12717 – volume: 15 issue: 1 year: 2024 ident: 1995_CR9 publication-title: Nat Commun doi: 10.1038/s41467-024-50760-9 – volume: 391 start-page: 538 issue: 6 year: 2024 ident: 1995_CR25 publication-title: N Engl J Med doi: 10.1056/NEJMra2301292 – volume: 60 issue: 4 year: 2023 ident: 1995_CR36 publication-title: Psychophysiology doi: 10.1111/psyp.14205 – volume: 5 start-page: 355 issue: 3 year: 2023 ident: 1995_CR43 publication-title: Nat Metab doi: 10.1038/s42255-023-00758-2 – volume: 15 issue: 12 year: 2019 ident: 1995_CR14 publication-title: PLoS Med doi: 10.1371/journal.pmed.1002718 – ident: 1995_CR16 doi: 10.1101/2020.07.10.20147777 – volume: 68 start-page: 667 issue: 6 year: 2013 ident: 1995_CR20 publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/gls233 – volume: 9 start-page: 2629 issue: 12 year: 2017 ident: 1995_CR33 publication-title: Aging doi: 10.18632/aging.101352 – volume: 89 start-page: 30 year: 2017 ident: 1995_CR32 publication-title: Exp Gerontol doi: 10.1016/j.exger.2016.12.021 – volume: 6 start-page: 905 issue: 36 year: 2024 ident: 1995_CR18 publication-title: China CDC Wkly doi: 10.46234/ccdcw2024.069 – volume: 294 start-page: 2712 issue: 21 year: 2005 ident: 1995_CR3 publication-title: JAMA doi: 10.1001/jama.294.21.2712 – volume: 594 start-page: 100 issue: 7861 year: 2021 ident: 1995_CR6 publication-title: Nature doi: 10.1038/s41586-021-03547-7 – volume: 373 start-page: 415 issue: 5 year: 2015 ident: 1995_CR24 publication-title: N Engl J Med doi: 10.1056/NEJMoa1500245 – volume: 13 issue: 20 year: 2021 ident: 1995_CR40 publication-title: Cancers (Basel) doi: 10.3390/cancers13205041 – volume: 14 start-page: 1091 issue: 4 year: 2023 ident: 1995_CR7 publication-title: Aging Dis – volume: 62 start-page: 901 issue: 5 year: 2014 ident: 1995_CR35 publication-title: J Am Geriatr Soc doi: 10.1111/jgs.12773 – volume: 398 start-page: 906 issue: 10303 year: 2021 ident: 1995_CR4 publication-title: Lancet doi: 10.1016/S0140-6736(21)00630-9 – volume: 35 start-page: 3115 issue: 12 year: 2023 ident: 1995_CR29 publication-title: Aging Clin Exp Res doi: 10.1007/s40520-023-02607-4 – volume: 24 start-page: 2911 issue: 19 year: 2005 ident: 1995_CR19 publication-title: Stat Med doi: 10.1002/sim.2165 – volume: 5 start-page: e45 issue: 1 year: 2024 ident: 1995_CR31 publication-title: Lancet Healthy Longev doi: 10.1016/S2666-7568(23)00220-9 – volume: 10 issue: 7 year: 2020 ident: 1995_CR17 publication-title: BMJ Open doi: 10.1136/bmjopen-2019-035430 – volume: 13 issue: 1 year: 2022 ident: 1995_CR10 publication-title: Nat Commun doi: 10.1038/s41467-022-34487-z – year: 2020 ident: 1995_CR21 publication-title: Elife doi: 10.7554/eLife.51507 – volume: 11 issue: 1 year: 2021 ident: 1995_CR26 publication-title: Sci Rep doi: 10.1038/s41598-021-86854-3 – volume: 15 start-page: 881 issue: 4 year: 2024 ident: 1995_CR27 publication-title: Eur Geriatr Med doi: 10.1007/s41999-024-00974-3 – volume: 392 start-page: 1736 issue: 10159 year: 2018 ident: 1995_CR1 publication-title: Lancet doi: 10.1016/S0140-6736(18)32203-7 – volume: 29 start-page: 1221 issue: 5 year: 2023 ident: 1995_CR12 publication-title: Nat Med doi: 10.1038/s41591-023-02296-6 – volume: 89 year: 2023 ident: 1995_CR30 publication-title: EBioMedicine doi: 10.1016/j.ebiom.2023.104458 – volume: 134 start-page: 243 issue: 2 year: 2021 ident: 1995_CR42 publication-title: Am J Med doi: 10.1016/j.amjmed.2020.07.022 – volume: 22 year: 2022 ident: 1995_CR2 publication-title: Lancet Reg Health – volume: 135 start-page: 370 issue: 3 year: 1972 ident: 1995_CR23 publication-title: Journal of the Royal Statistical Society Series A (General) doi: 10.2307/2344614 – year: 2025 ident: 1995_CR38 publication-title: Pathogens doi: 10.3390/pathogens14010041 – volume: 127 start-page: 240 issue: 3 year: 2006 ident: 1995_CR13 publication-title: Mech Ageing Dev doi: 10.1016/j.mad.2005.10.004 – volume: 75 start-page: S61 issue: Suppl 1 year: 2022 ident: 1995_CR39 publication-title: Clin Infect Dis doi: 10.1093/cid/ciac397 – volume: 47 start-page: 193 issue: 2 year: 2018 ident: 1995_CR28 publication-title: Age Ageing doi: 10.1093/ageing/afx162 – volume: 224 year: 2025 ident: 1995_CR41 publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2025.112213 |
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