Comparative proteomic analysis of renal tissue of normotensive and hypertensive rats
Comparative proteomic analysis of kidney tissue from normotensive (WKY) and spontaneously hypertensive (SHR) rats revealed quantitative and qualitative changes in renal proteins. The number of renal proteins specific for WKY rats (blood pressure 110-120 mm Hg) was 13-16. There were 20-24 renal prote...
Uložené v:
| Vydané v: | Biomeditsinskaia khimiia Ročník 70; číslo 2; s. 89 |
|---|---|
| Hlavní autori: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Russia (Federation)
01.04.2024
|
| Predmet: | |
| ISSN: | 2310-6972 |
| On-line prístup: | Zistit podrobnosti o prístupe |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Comparative proteomic analysis of kidney tissue from normotensive (WKY) and spontaneously hypertensive (SHR) rats revealed quantitative and qualitative changes in renal proteins. The number of renal proteins specific for WKY rats (blood pressure 110-120 mm Hg) was 13-16. There were 20-24 renal proteins specific for SHR (blood pressure 180 mm Hg and more). The total number of identified renal proteins common for both rat strains included 972-975 proteins. A pairwise comparison of all possible (SHR-WKY) variants identified 8 proteins specific only for normotensive (WKY) animals, and 7 proteins specific only for hypertensive ones (SHR). Taking into consideration their biological roles, the lack of some enzyme proteins in hypertensive rats (for example, biliverdin reductase A) reduces the production of molecules exhibiting antihypertensive properties, while the appearance of others (e.g. betaine-homocysteine S-methyltransferase 2, septin 2, etc.) can be interpreted as a compensatory reaction. Renal proteins with altered relative content (with more than 2.5-fold change) accounted for no more than 5% of all identified proteins. Among the proteins with an increased relative content in hypertensive animals, the largest group consisted of proteins involved in the processes of energy generation and carbohydrate metabolism, as well as antioxidant and protective proteins. In the context of the development of hypertension, the identified relative changes can apparently be considered compensatory. Among the proteins with the most pronounced decrease in the relative content in hypertensive rats, the dramatic reduction in acyl-CoA medium-chain synthetase-3 (ACSM3) appears to make an important contribution to the development of renal pathology in these animals. |
|---|---|
| AbstractList | Comparative proteomic analysis of kidney tissue from normotensive (WKY) and spontaneously hypertensive (SHR) rats revealed quantitative and qualitative changes in renal proteins. The number of renal proteins specific for WKY rats (blood pressure 110-120 mm Hg) was 13-16. There were 20-24 renal proteins specific for SHR (blood pressure 180 mm Hg and more). The total number of identified renal proteins common for both rat strains included 972-975 proteins. A pairwise comparison of all possible (SHR-WKY) variants identified 8 proteins specific only for normotensive (WKY) animals, and 7 proteins specific only for hypertensive ones (SHR). Taking into consideration their biological roles, the lack of some enzyme proteins in hypertensive rats (for example, biliverdin reductase A) reduces the production of molecules exhibiting antihypertensive properties, while the appearance of others (e.g. betaine-homocysteine S-methyltransferase 2, septin 2, etc.) can be interpreted as a compensatory reaction. Renal proteins with altered relative content (with more than 2.5-fold change) accounted for no more than 5% of all identified proteins. Among the proteins with an increased relative content in hypertensive animals, the largest group consisted of proteins involved in the processes of energy generation and carbohydrate metabolism, as well as antioxidant and protective proteins. In the context of the development of hypertension, the identified relative changes can apparently be considered compensatory. Among the proteins with the most pronounced decrease in the relative content in hypertensive rats, the dramatic reduction in acyl-CoA medium-chain synthetase-3 (ACSM3) appears to make an important contribution to the development of renal pathology in these animals. Comparative proteomic analysis of kidney tissue from normotensive (WKY) and spontaneously hypertensive (SHR) rats revealed quantitative and qualitative changes in renal proteins. The number of renal proteins specific for WKY rats (blood pressure 110-120 mm Hg) was 13-16. There were 20-24 renal proteins specific for SHR (blood pressure 180 mm Hg and more). The total number of identified renal proteins common for both rat strains included 972-975 proteins. A pairwise comparison of all possible (SHR-WKY) variants identified 8 proteins specific only for normotensive (WKY) animals, and 7 proteins specific only for hypertensive ones (SHR). Taking into consideration their biological roles, the lack of some enzyme proteins in hypertensive rats (for example, biliverdin reductase A) reduces the production of molecules exhibiting antihypertensive properties, while the appearance of others (e.g. betaine-homocysteine S-methyltransferase 2, septin 2, etc.) can be interpreted as a compensatory reaction. Renal proteins with altered relative content (with more than 2.5-fold change) accounted for no more than 5% of all identified proteins. Among the proteins with an increased relative content in hypertensive animals, the largest group consisted of proteins involved in the processes of energy generation and carbohydrate metabolism, as well as antioxidant and protective proteins. In the context of the development of hypertension, the identified relative changes can apparently be considered compensatory. Among the proteins with the most pronounced decrease in the relative content in hypertensive rats, the dramatic reduction in acyl-CoA medium-chain synthetase-3 (ACSM3) appears to make an important contribution to the development of renal pathology in these animals.Comparative proteomic analysis of kidney tissue from normotensive (WKY) and spontaneously hypertensive (SHR) rats revealed quantitative and qualitative changes in renal proteins. The number of renal proteins specific for WKY rats (blood pressure 110-120 mm Hg) was 13-16. There were 20-24 renal proteins specific for SHR (blood pressure 180 mm Hg and more). The total number of identified renal proteins common for both rat strains included 972-975 proteins. A pairwise comparison of all possible (SHR-WKY) variants identified 8 proteins specific only for normotensive (WKY) animals, and 7 proteins specific only for hypertensive ones (SHR). Taking into consideration their biological roles, the lack of some enzyme proteins in hypertensive rats (for example, biliverdin reductase A) reduces the production of molecules exhibiting antihypertensive properties, while the appearance of others (e.g. betaine-homocysteine S-methyltransferase 2, septin 2, etc.) can be interpreted as a compensatory reaction. Renal proteins with altered relative content (with more than 2.5-fold change) accounted for no more than 5% of all identified proteins. Among the proteins with an increased relative content in hypertensive animals, the largest group consisted of proteins involved in the processes of energy generation and carbohydrate metabolism, as well as antioxidant and protective proteins. In the context of the development of hypertension, the identified relative changes can apparently be considered compensatory. Among the proteins with the most pronounced decrease in the relative content in hypertensive rats, the dramatic reduction in acyl-CoA medium-chain synthetase-3 (ACSM3) appears to make an important contribution to the development of renal pathology in these animals. |
| Author | Fedchenko, V I Medvedev, A E Kaloshina, S A Zavyalova, M G Buneeva, O A Zgoda, V G |
| Author_xml | – sequence: 1 givenname: O A surname: Buneeva fullname: Buneeva, O A organization: Institute of Biomedical Chemistry, Moscow, Russia – sequence: 2 givenname: V I surname: Fedchenko fullname: Fedchenko, V I organization: Institute of Biomedical Chemistry, Moscow, Russia – sequence: 3 givenname: S A surname: Kaloshina fullname: Kaloshina, S A organization: Institute of Biomedical Chemistry, Moscow, Russia – sequence: 4 givenname: M G surname: Zavyalova fullname: Zavyalova, M G organization: Institute of Biomedical Chemistry, Moscow, Russia – sequence: 5 givenname: V G surname: Zgoda fullname: Zgoda, V G organization: Institute of Biomedical Chemistry, Moscow, Russia – sequence: 6 givenname: A E surname: Medvedev fullname: Medvedev, A E organization: Institute of Biomedical Chemistry, Moscow, Russia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38711408$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kL1PwzAQxT0U0VK6M6GMLAF_JvYIEQWkIhjKHNnORVhKnGAnSP3vcUU7nd7d757e3RVa-MEDQjcE3xOJVfnw-fReUUx5iTHFUi3QijKC80KVdIk2MTqThkQJLtUlWjJZEsKxXKF9NfSjDnpyv5CNYZhg6J3NtNfdIbqYDW0WIIlscjHOcNR-CH3ifDyuaN9k34cRwrmRrOI1umh1F2Fzqmv0tX3eV6_57uPlrXrc5ZaKQuWF1I1pWmgZ04piKFtljeaUC9M0igG21lBiNaTDGIiEFwpYKyzlmhuu6Rrd_fum4D8zxKnuXbTQddrDMMeaYUEUJ6UUCb09obPpoanH4HodDvX5E_QPQpNjOw |
| CitedBy_id | crossref_primary_10_1093_ajh_hpae150 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.18097/PBMC20247002089 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| ExternalDocumentID | 38711408 |
| Genre | Journal Article Comparative Study |
| GroupedDBID | 53G CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c2569-68adbdfef33a920e7f9cba4245bdd93e0ccb21cae2023e568a69e3f5c24a4b4a2 |
| IEDL.DBID | 7X8 |
| ISSN | 2310-6972 |
| IngestDate | Wed Oct 01 14:45:21 EDT 2025 Thu Jan 02 22:39:34 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | arterial hypertension renal tissue proteomic profiling WKY and SHR rats |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c2569-68adbdfef33a920e7f9cba4245bdd93e0ccb21cae2023e568a69e3f5c24a4b4a2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://pbmc.ibmc.msk.ru/pdf/PBMC-2024-70-2-89-en |
| PMID | 38711408 |
| PQID | 3051941785 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_3051941785 pubmed_primary_38711408 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-Apr |
| PublicationDateYYYYMMDD | 2024-04-01 |
| PublicationDate_xml | – month: 04 year: 2024 text: 2024-Apr |
| PublicationDecade | 2020 |
| PublicationPlace | Russia (Federation) |
| PublicationPlace_xml | – name: Russia (Federation) |
| PublicationTitle | Biomeditsinskaia khimiia |
| PublicationTitleAlternate | Biomed Khim |
| PublicationYear | 2024 |
| SSID | ssib024195489 ssib040281610 ssib025541122 |
| Score | 2.2869067 |
| Snippet | Comparative proteomic analysis of kidney tissue from normotensive (WKY) and spontaneously hypertensive (SHR) rats revealed quantitative and qualitative changes... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 89 |
| SubjectTerms | Animals Blood Pressure Hypertension - metabolism Kidney - metabolism Male Proteome - analysis Proteome - metabolism Proteomics - methods Rats Rats, Inbred SHR Rats, Inbred WKY |
| Title | Comparative proteomic analysis of renal tissue of normotensive and hypertensive rats |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/38711408 https://www.proquest.com/docview/3051941785 |
| Volume | 70 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV07T8MwELaAMrDwEK_yUpBYIxLbSewJQUXFQKsOReoW-SmmpLTA7-fOcdsNIbFESmRbyvni-87nfB8hdybj3BSmSh3SXHLhslTkikGqwn3uqcpzHdj1X6vxWMxmchI33JbxWOVqTQwLtW0N7pHfM8QaHLXkH-YfKapGYXU1Smhskx4DKINeXc3W_gTBCenM1uEa0DMHeLEO55A6CQA8WdCfg-WolBWNlUyBxI6Tp9GAwihVULL8BYOGWDQ8-O9bHJL9iEKTx85tjsiWa47JdLBhAk8CfwP-sZyoSFuStD5ZOOz2GSYL7xtAvG08Aw8NbfIOae1i9QCGWp6Qt-HzdPCSRtGF1AD6kWkplNXWO8-YkjRzlZdGK6yPamslc5kxmuZGOdRddwU0L6VjvjCUK665oqdkp2kbd04Sq4wtRck8845r7ZQEs_IiyxxguIKaPrldGakGp8ZKhWpc-7WsN2bqk7PO0vW8Y9-oGaR4kBWKiz_0viR7OIHdSZsr0vPwSbtrsmu-wVKLm-AtcB1PRj8tg8fB |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparative+proteomic+analysis+of+renal+tissue+of+normotensive+and+hypertensive+rats&rft.jtitle=Biomeditsinskaia+khimiia&rft.au=Buneeva%2C+O+A&rft.au=Fedchenko%2C+V+I&rft.au=Kaloshina%2C+S+A&rft.au=Zavyalova%2C+M+G&rft.date=2024-04-01&rft.issn=2310-6972&rft.volume=70&rft.issue=2&rft.spage=89&rft_id=info:doi/10.18097%2FPBMC20247002089&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2310-6972&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2310-6972&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2310-6972&client=summon |