Pioglitazone repurposing via in-situ gelling system: An effective topical strategy for wound management

This study investigated pioglitazone hydrochloride (PGZ), an antidiabetic drug, as a wound healing promoter employing the in-situ gel approach. Poloxamer 407 was selected due to its thermo-reversible sol-gel transition properties, in the presence or absence of chitosan. PGZ solubility was enhanced b...

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Veröffentlicht in:	Journal of drug delivery science and technology Jg. 106; S. 106723
Hauptverfasser:	Abdelkader, Dalia H., Elshaer, Samar M., Elkordy, Eman A., Sarhan, Naglaa I., Essa, Ebtessam A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Elsevier B.V 01.04.2025
Schlagworte:	A dorsal region open incision Alpha-smooth muscle actin (α SMA) Drug repurposing Solid dispersion Thermos-reversible gelation Drug repurposing Thermos-reversible gelation Solid dispersion A dorsal region open incision Alpha-smooth muscle actin (α SMA)
ISSN:	1773-2247
Online-Zugang:	Volltext
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