Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis

Evidence regarding the relationship between serum trace element levels and immune-mediated inflammatory skin diseases (IMSDs) is inconsistent. In this systematic review and meta-analysis we aimed to evaluate the association between selected serum trace element levels (zinc [Zn], copper [Cu], iron [F...

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Vydáno v:Nutrition reviews Ročník 83; číslo 8; s. 1462
Hlavní autoři: Shao, Xinyi, Ou, Yi, Chen, Tingqiao, Deng, Binbin, Zhang, Jingbo, Chen, Jin
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.08.2025
Témata:
Copper - blood
Female
Humans
Iron - blood
Selenium - blood
Skin Diseases - blood
Skin Diseases - immunology
Trace Elements - blood
Zinc - blood
immune-mediated inflammatory skin diseases
meta-analysis Newcastle–Ottawa scale
trace elements
ISSN:1753-4887, 1753-4887
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Shrnutí:Evidence regarding the relationship between serum trace element levels and immune-mediated inflammatory skin diseases (IMSDs) is inconsistent. In this systematic review and meta-analysis we aimed to evaluate the association between selected serum trace element levels (zinc [Zn], copper [Cu], iron [Fe], selenium [Se], and calcium [Ca]) and IMSDs (psoriasis, vitiligo, atopic dermatitis [AD], alopecia areata [AA], hidradenitis suppurativa, and bullous diseases). We conducted a comprehensive search on the PubMed, EMBASE, Scopus, China National Knowledge Infrastructure, and Web of Science databases from the database inception date to May 2, 2024. Studies measuring serum, plasma, or whole-blood levels of Zn, Cu, Fe, Se, or Ca in patients with IMSD compared to those in healthy controls were included. This study followed the guidelines of the Meta-analysis of Observational Studies in Epidemiology and the Preferred Reporting Items for Systematic Review and Meta-analyses guidelines. Two authors (X.Y.S. and Y.O.) independently reviewed the titles and abstracts of the identified studies using a standardized collection form. The primary outcome was the standardized mean difference with a 95% CI in serum trace element levels (Zn, Cu, Fe, Se, and Ca) between patients with IMSDs and healthy controls. Overall, 113 studies involving 7014 patients with IMSD were included in the meta-analysis. Compared with those in the healthy control group, serum Zn levels decreased in patients with vitiligo, psoriasis, and AA; serum Cu levels increased in patients with psoriasis, AD, and AA; serum Se and Fe levels decreased in patients with psoriasis and AD. Serum trace element levels showed more significant changes in patients with IMSDs than in healthy controls. These findings suggest that alterations in trace element levels may be associated with the occurrence, development, and prognosis of IMSDs.
Bibliografie:ObjectType-Article-1
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ISSN:1753-4887
1753-4887
DOI:10.1093/nutrit/nuaf015