Primary advanced malignant melanoma of the uterine cervix treated with a combination of nivolumab and concurrent radiotherapy: A case report
•Cervical malignant melanoma is very rare and has no standard treatment.•Nivolumab plus radiotherapy was used as the initial treatment in this case.•Tumor shrinkage and symptom control were achieved with combination therapy.•The patient developed lymph node metastasis and died 16 months after treatm...
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| Vydané v: | Current problems in cancer. Case reports Ročník 20; s. 100396 |
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01.12.2025
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| ISSN: | 2666-6219, 2666-6219 |
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| Abstract | •Cervical malignant melanoma is very rare and has no standard treatment.•Nivolumab plus radiotherapy was used as the initial treatment in this case.•Tumor shrinkage and symptom control were achieved with combination therapy.•The patient developed lymph node metastasis and died 16 months after treatment.•This is the first report on use of nivolumab and radiotherapy for cervical melanoma.
Malignant melanoma accounts for 1–4 % of all gynecological malignancies, with most cases originating in the vulva and/or vagina. Primary malignant uterine melanomas are rare. Although there are reports of initial treatment with nivolumab and combination therapy with nivolumab and radiotherapy for recurrent lesions, no standardized treatment protocol has been established. This case report describes a 74-year-old woman diagnosed with International Federation of Gynecology and Obstetrics stage IV primary malignant melanoma of the cervix. Nivolumab and radiotherapy were concurrently administered to the primary lesion, resulting in tumor mass reduction. However, new pelvic lymph node metastases were observed at 6 months. The same combination therapy was administered but proved ineffective, leading to disease progression and death. To our best knowledge, this is the first report on the combined use of immune checkpoint inhibitors and radiotherapy as the initial treatment for primary malignant melanoma of the cervix. In advanced cases, initial treatment may result in primary lesion reduction and symptom control. |
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| AbstractList | •Cervical malignant melanoma is very rare and has no standard treatment.•Nivolumab plus radiotherapy was used as the initial treatment in this case.•Tumor shrinkage and symptom control were achieved with combination therapy.•The patient developed lymph node metastasis and died 16 months after treatment.•This is the first report on use of nivolumab and radiotherapy for cervical melanoma.
Malignant melanoma accounts for 1–4 % of all gynecological malignancies, with most cases originating in the vulva and/or vagina. Primary malignant uterine melanomas are rare. Although there are reports of initial treatment with nivolumab and combination therapy with nivolumab and radiotherapy for recurrent lesions, no standardized treatment protocol has been established. This case report describes a 74-year-old woman diagnosed with International Federation of Gynecology and Obstetrics stage IV primary malignant melanoma of the cervix. Nivolumab and radiotherapy were concurrently administered to the primary lesion, resulting in tumor mass reduction. However, new pelvic lymph node metastases were observed at 6 months. The same combination therapy was administered but proved ineffective, leading to disease progression and death. To our best knowledge, this is the first report on the combined use of immune checkpoint inhibitors and radiotherapy as the initial treatment for primary malignant melanoma of the cervix. In advanced cases, initial treatment may result in primary lesion reduction and symptom control. •Cervical malignant melanoma is very rare and has no standard treatment•Nivolumab plus radiotherapy was used as the initial treatment in this case•Tumor shrinkage and symptom control were achieved with combination therapy•The patient developed lymph node metastasis and died 16 months after treatment•This is the first report on use of nivolumab and radiotherapy for cervical melanoma Malignant melanoma accounts for 1–4% of all gynecological malignancies, with most cases originating in the vulva and/or vagina. Primary malignant uterine melanomas are rare. Although there are reports of initial treatment with nivolumab and combination therapy with nivolumab and radiotherapy for recurrent lesions, no standardized treatment protocol has been established. This case report describes a 74-year-old woman diagnosed with International Federation of Gynecology and Obstetrics stage IV primary malignant melanoma of the cervix. Nivolumab and radiotherapy were concurrently administered to the primary lesion, resulting in tumor mass reduction. However, new pelvic lymph node metastases were observed at 6 months. The same combination therapy was administered but proved ineffective, leading to disease progression and death. To our best knowledge, this is the first report on the combined use of immune checkpoint inhibitors and radiotherapy as the initial treatment for primary malignant melanoma of the cervix. In advanced cases, initial treatment may result in primary lesion reduction and symptom control. Highlights•Cervical malignant melanoma is very rare and has no standard treatment •Nivolumab plus radiotherapy was used as the initial treatment in this case •Tumor shrinkage and symptom control were achieved with combination therapy •The patient developed lymph node metastasis and died 16 months after treatment •This is the first report on use of nivolumab and radiotherapy for cervical melanoma |
| ArticleNumber | 100396 |
| Author | Furukawa, Shigenori Miura, Hideki Sato, Tetsu Okabe, Chikako Soeda, Shu Fujimori, Keiya Kato, Asami Kamo, Norihito |
| Author_xml | – sequence: 1 givenname: Norihito surname: Kamo fullname: Kamo, Norihito email: k0810@fmu.ac.jp organization: Department of Obstetrics and Gynecology, Shirakawa Kosei General Hospital, 2-1 Toyochi Kamiyajiro, Shirakawa City, Fukushima 961-0005, Japan – sequence: 2 givenname: Shigenori surname: Furukawa fullname: Furukawa, Shigenori email: s-furu@fmu.ac.jp organization: Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan – sequence: 3 givenname: Asami surname: Kato fullname: Kato, Asami email: askatou@fmu.ac.jp organization: Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan – sequence: 4 givenname: Chikako surname: Okabe fullname: Okabe, Chikako email: chika729@fmu.ac.jp organization: Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan – sequence: 5 givenname: Hideki surname: Miura fullname: Miura, Hideki email: m-hideki@fmu.ac.jp organization: Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan – sequence: 6 givenname: Tetsu surname: Sato fullname: Sato, Tetsu email: tetsus@fmu.ac.jp organization: Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan – sequence: 7 givenname: Shu surname: Soeda fullname: Soeda, Shu email: s-soeda@fmu.ac.jp organization: Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan – sequence: 8 givenname: Keiya surname: Fujimori fullname: Fujimori, Keiya email: fujimori@fmu.ac.jp organization: Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan |
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| Cites_doi | 10.1097/PGP.0000000000000480 10.1093/ajcp/46.4.420 10.1001/jamaoncol.2019.1478 10.1186/s12935-021-02407-8 10.3390/diagnostics14050547 10.1016/S0140-6736(24)00317-9 10.3390/cancers14194575 10.1016/j.critrevonc.2011.03.008 10.3389/fonc.2019.00835 10.5402/2011/683020 10.1056/NEJMoa1200690 10.1007/s00795-023-00377-6 |
| ContentType | Journal Article |
| Copyright | 2025 |
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| Keywords | Primary malignant melanoma Immune checkpoint inhibitor Cervix Radiotherapy Nivolumab radiotherapy cervix immune checkpoint inhibitor nivolumab primary malignant melanoma |
| Language | English |
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| Snippet | •Cervical malignant melanoma is very rare and has no standard treatment.•Nivolumab plus radiotherapy was used as the initial treatment in this case.•Tumor... Highlights•Cervical malignant melanoma is very rare and has no standard treatment •Nivolumab plus radiotherapy was used as the initial treatment in this case... •Cervical malignant melanoma is very rare and has no standard treatment•Nivolumab plus radiotherapy was used as the initial treatment in this case•Tumor... |
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| SubjectTerms | Cervix Hematology, Oncology, and Palliative Medicine Immune checkpoint inhibitor Nivolumab Primary malignant melanoma Radiotherapy |
| Title | Primary advanced malignant melanoma of the uterine cervix treated with a combination of nivolumab and concurrent radiotherapy: A case report |
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