A Novel Scoring System in Predicting Prognosis After Adjuvant FOLFOX Chemotherapy in Gastric Cancer
To evaluate the impact of neutrophil-to-lymphocyte ratio (NLR) and preoperative prognostic nutritional index (PNI) on prognosis of gastric cancer (GC) after adjuvant FOLFOX chemotherapy. Data on 749 GC patients who received operation after by adjuvant FOLFOX chemotherapy between January 2013 and Dec...
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| Veröffentlicht in: | Cancer biotherapy & radiopharmaceuticals Jg. 38; H. 6; S. 388 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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01.08.2023
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| ISSN: | 1557-8852, 1557-8852 |
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| Abstract | To evaluate the impact of neutrophil-to-lymphocyte ratio (NLR) and preoperative prognostic nutritional index (PNI) on prognosis of gastric cancer (GC) after adjuvant FOLFOX chemotherapy.
Data on 749 GC patients who received operation after by adjuvant FOLFOX chemotherapy between January 2013 and December 2015 were enrolled in this study, retrospectively. Receiver-operating characteristic curve analysis was employed to assess optimal cutoff thresholds for PNI and NLR. The GC subjects having a low PNI (<52.8) and high NLR (>1.79) received a score of 2. Any variable that met these standards was scored as 1. If none of the two variables met these standards of the patient was assigned a score of 0. Correlation between PNI-NLR score and GC stage was also evaluated.
The mean overall survival (OS) and 5-year OS rate for subjects with PNI-NLR = 2 was lower than those of subjects with PNI-NLR = 1, or 0 (40.9% vs. 52.1%, 76.4% [46.0 vs. 61.0], 68.0 months,
≤ 0.001). In multivariate analyses, the PNI-NLR score (
≤ 0.001) and WHO grade (
≤ 0.001) showed potential to independently influence OS.
High PNI-NLR scores can independently affect worse prognosis of GC. Thus, it can be utilized to differentiate low risk from high risk subjects. |
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| AbstractList | To evaluate the impact of neutrophil-to-lymphocyte ratio (NLR) and preoperative prognostic nutritional index (PNI) on prognosis of gastric cancer (GC) after adjuvant FOLFOX chemotherapy.
Data on 749 GC patients who received operation after by adjuvant FOLFOX chemotherapy between January 2013 and December 2015 were enrolled in this study, retrospectively. Receiver-operating characteristic curve analysis was employed to assess optimal cutoff thresholds for PNI and NLR. The GC subjects having a low PNI (<52.8) and high NLR (>1.79) received a score of 2. Any variable that met these standards was scored as 1. If none of the two variables met these standards of the patient was assigned a score of 0. Correlation between PNI-NLR score and GC stage was also evaluated.
The mean overall survival (OS) and 5-year OS rate for subjects with PNI-NLR = 2 was lower than those of subjects with PNI-NLR = 1, or 0 (40.9% vs. 52.1%, 76.4% [46.0 vs. 61.0], 68.0 months,
≤ 0.001). In multivariate analyses, the PNI-NLR score (
≤ 0.001) and WHO grade (
≤ 0.001) showed potential to independently influence OS.
High PNI-NLR scores can independently affect worse prognosis of GC. Thus, it can be utilized to differentiate low risk from high risk subjects. Purpose: To evaluate the impact of neutrophil-to-lymphocyte ratio (NLR) and preoperative prognostic nutritional index (PNI) on prognosis of gastric cancer (GC) after adjuvant FOLFOX chemotherapy. Materials and Methods: Data on 749 GC patients who received operation after by adjuvant FOLFOX chemotherapy between January 2013 and December 2015 were enrolled in this study, retrospectively. Receiver-operating characteristic curve analysis was employed to assess optimal cutoff thresholds for PNI and NLR. The GC subjects having a low PNI (<52.8) and high NLR (>1.79) received a score of 2. Any variable that met these standards was scored as 1. If none of the two variables met these standards of the patient was assigned a score of 0. Correlation between PNI-NLR score and GC stage was also evaluated. Results: The mean overall survival (OS) and 5-year OS rate for subjects with PNI-NLR = 2 was lower than those of subjects with PNI-NLR = 1, or 0 (40.9% vs. 52.1%, 76.4% [46.0 vs. 61.0], 68.0 months, p ≤ 0.001). In multivariate analyses, the PNI-NLR score (p ≤ 0.001) and WHO grade (p ≤ 0.001) showed potential to independently influence OS. Conclusions: High PNI-NLR scores can independently affect worse prognosis of GC. Thus, it can be utilized to differentiate low risk from high risk subjects.Purpose: To evaluate the impact of neutrophil-to-lymphocyte ratio (NLR) and preoperative prognostic nutritional index (PNI) on prognosis of gastric cancer (GC) after adjuvant FOLFOX chemotherapy. Materials and Methods: Data on 749 GC patients who received operation after by adjuvant FOLFOX chemotherapy between January 2013 and December 2015 were enrolled in this study, retrospectively. Receiver-operating characteristic curve analysis was employed to assess optimal cutoff thresholds for PNI and NLR. The GC subjects having a low PNI (<52.8) and high NLR (>1.79) received a score of 2. Any variable that met these standards was scored as 1. If none of the two variables met these standards of the patient was assigned a score of 0. Correlation between PNI-NLR score and GC stage was also evaluated. Results: The mean overall survival (OS) and 5-year OS rate for subjects with PNI-NLR = 2 was lower than those of subjects with PNI-NLR = 1, or 0 (40.9% vs. 52.1%, 76.4% [46.0 vs. 61.0], 68.0 months, p ≤ 0.001). In multivariate analyses, the PNI-NLR score (p ≤ 0.001) and WHO grade (p ≤ 0.001) showed potential to independently influence OS. Conclusions: High PNI-NLR scores can independently affect worse prognosis of GC. Thus, it can be utilized to differentiate low risk from high risk subjects. |
| Author | Zhang, Zhengjun Li, Guangyao Li, Ziqiang Ren, Lei Wang, Wentao Teng, Mujian Ge, Guochao Zhu, Yong |
| Author_xml | – sequence: 1 givenname: Guochao orcidid: 0000-0002-8881-1590 surname: Ge fullname: Ge, Guochao organization: Department of Gastrointestinal Surgery, the Affiliated Wuhu Hospital of East China Normal University (The People's Second Hospital of Wuhu), Wuhu, China – sequence: 2 givenname: Guangyao surname: Li fullname: Li, Guangyao organization: Department of Gastrointestinal Surgery, the Affiliated Wuhu Hospital of East China Normal University (The People's Second Hospital of Wuhu), Wuhu, China – sequence: 3 givenname: Zhengjun surname: Zhang fullname: Zhang, Zhengjun organization: Department of Gastrointestinal Surgery, the Affiliated Wuhu Hospital of East China Normal University (The People's Second Hospital of Wuhu), Wuhu, China – sequence: 4 givenname: Yong surname: Zhu fullname: Zhu, Yong organization: Department of Gastrointestinal Surgery, Cheeloo College of Medicine, Shandong University, Shandong Provincial Hospital, Jinan, China – sequence: 5 givenname: Wentao surname: Wang fullname: Wang, Wentao organization: Department of Liver Transplantation and Hepatic Surgery, Cheeloo College of Medicine, Shandong University, Shandong Qianfoshan Hospital, Jinan, China – sequence: 6 givenname: Lei surname: Ren fullname: Ren, Lei organization: Department of Liver Transplantation and Hepatic Surgery, Cheeloo College of Medicine, Shandong University, Shandong Qianfoshan Hospital, Jinan, China – sequence: 7 givenname: Ziqiang surname: Li fullname: Li, Ziqiang organization: Department of Liver Transplantation and Hepatic Surgery, Cheeloo College of Medicine, Shandong University, Shandong Qianfoshan Hospital, Jinan, China – sequence: 8 givenname: Mujian surname: Teng fullname: Teng, Mujian organization: Department of Liver Transplantation and Hepatic Surgery, Cheeloo College of Medicine, Shandong University, Shandong Qianfoshan Hospital, Jinan, China |
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| Title | A Novel Scoring System in Predicting Prognosis After Adjuvant FOLFOX Chemotherapy in Gastric Cancer |
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