Reduced responsiveness of blood leukocytes to lipopolysaccharide does not predict nosocomial infections in critically ill patients

Compared with healthy subjects, whole blood leukocytes of patients were less responsive to ex vivo stimulation with LPS, as reflected by strongly reduced TNF?, IL-1? and IL-6 levels in culture supernatants. Conclusion The extent of reduced LPS responsiveness of blood leukocytes in critically ill pat...

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Bibliographic Details
Published in:	Critical care (London, England) Vol. 19; no. Suppl 1; p. P38
Main Authors:	Van Vught, LA, Wiewel, MA, Hoogendijk, AJ, Scicluna, BP, Belkasim, H, Horn, J, Schultz, MJ, Van der Poll, T
Format:	Journal Article
Language:	English
Published:	London BioMed Central 16.03.2015 BioMed Central Ltd Springer Nature B.V
Subjects:	Care and treatment Critical Care Medicine Critically ill Disease susceptibility Emergency Medicine Immune response Intensive Medical research Medicine Medicine & Public Health Medicine, Experimental Nosocomial infections Observations Poster Presentation Tumor necrosis factor-TNF Netherlands Culture Supernatant Systemic Inflammatory Response Syndrome Healthy Individual Tumor Necrosis Factor Nosocomial Infection
ISSN:	1364-8535, 1364-8535, 1366-609X, 1466-609X
Online Access:	Get full text
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