Reduced responsiveness of blood leukocytes to lipopolysaccharide does not predict nosocomial infections in critically ill patients

Compared with healthy subjects, whole blood leukocytes of patients were less responsive to ex vivo stimulation with LPS, as reflected by strongly reduced TNF?, IL-1? and IL-6 levels in culture supernatants. Conclusion The extent of reduced LPS responsiveness of blood leukocytes in critically ill pat...

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Published in:Critical care (London, England) Vol. 19; no. Suppl 1; p. P38
Main Authors: Van Vught, LA, Wiewel, MA, Hoogendijk, AJ, Scicluna, BP, Belkasim, H, Horn, J, Schultz, MJ, Van der Poll, T
Format: Journal Article
Language:English
Published: London BioMed Central 16.03.2015
BioMed Central Ltd
Springer Nature B.V
Subjects:
Care and treatment
Critical Care Medicine
Critically ill
Disease susceptibility
Emergency Medicine
Immune response
Intensive
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Nosocomial infections
Observations
Poster Presentation
Tumor necrosis factor-TNF
Netherlands
Culture Supernatant
Systemic Inflammatory Response Syndrome
Healthy Individual
Tumor Necrosis Factor
Nosocomial Infection
ISSN:1364-8535, 1364-8535, 1366-609X, 1466-609X
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Summary:Compared with healthy subjects, whole blood leukocytes of patients were less responsive to ex vivo stimulation with LPS, as reflected by strongly reduced TNF?, IL-1? and IL-6 levels in culture supernatants. Conclusion The extent of reduced LPS responsiveness of blood leukocytes in critically ill patients on the first day after ICU admission does not relate to the subsequent development of ICU-acquired infections.
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ISSN:1364-8535
1364-8535
1366-609X
1466-609X
DOI:10.1186/cc14118