Subject Specific Modelling of Electrical Conduction in the Body: A Case Study

Modelling of bioelectric phenomena in the human body poses unique problems compared to those encountered in other fields of engineering. Accurate definition of the physical domain and material properties is difficult due to geometrical complexity and uncertainty in tissue characterisation. A workflo...

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Vydáno v:Journal of biomimetics, biomaterials and biomedical engineering Ročník 10; s. 43 - 53
Hlavní autoři: Lau, Howard, Li, Qing, Ruys, Andrew John, Wang, Xiu, Carter, P.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Zurich Trans Tech Publications Ltd 16.05.2011
Témata:
Case studies
Data acquisition
Numerical analysis
Subject Specific Model
Diffusion Tensor MRI
Electrical Conduction
Finite Element Analysis (FEA)
ISSN:1662-1018, 1662-100X, 2296-9837, 1662-100X, 2296-9845
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Abstract Modelling of bioelectric phenomena in the human body poses unique problems compared to those encountered in other fields of engineering. Accurate definition of the physical domain and material properties is difficult due to geometrical complexity and uncertainty in tissue characterisation. A workflow is presented for finite element simulation of electric current in the body. This is illustrated through an application on a subject-specific cranial model for simulation of a cochlear implant. Operations required for the full workflow include: data acquisition, image registration and segmentation, material property assignment, numerical analysis, and visualisation. The case study described uses MRI imaging and diffusion tensor MRI for definition of the analysis domain and material properties with analysis conducted in ANSYS. Image registration and segmentation were accomplished using custom designed algorithms. Visualisation was achieved using a 24-bit red-green-blue colour scheme to represent directional vectors.
AbstractList Modelling of bioelectric phenomena in the human body poses unique problems compared to those encountered in other fields of engineering. Accurate definition of the physical domain and material properties is difficult due to geometrical complexity and uncertainty in tissue characterisation. A workflow is presented for finite element simulation of electric current in the body. This is illustrated through an application on a subject-specific cranial model for simulation of a cochlear implant. Operations required for the full workflow include: data acquisition, image registration and segmentation, material property assignment, numerical analysis, and visualisation. The case study described uses MRI imaging and diffusion tensor MRI for definition of the analysis domain and material properties with analysis conducted in ANSYS. Image registration and segmentation were accomplished using custom designed algorithms. Visualisation was achieved using a 24-bit red-green-blue colour scheme to represent directional vectors.
Author Li, Qing
Lau, Howard
Ruys, Andrew John
Carter, P.
Wang, Xiu
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– givenname: Qing
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  fullname: Li, Qing
  email: qing.li@sydney.edu.au
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– givenname: Andrew John
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  email: xiu.wang@sydney.e.du.au
  organization: University of Sydney : School of IT
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  surname: Carter
  fullname: Carter, P.
  email: pcarter@cochlear.com
  organization: Macquarie University : Cochlear Ltd
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Diffusion Tensor MRI
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Title Subject Specific Modelling of Electrical Conduction in the Body: A Case Study
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