Adaptive Blood Cell Variability in the Annual Life Cycle of the Ground Squirrel Urocitellus undulatus

The complete blood count (CBC) dynamics was investigated in long-tailed ground squirrels Urocitellus undulatus ( n = 100) during different periods of their annual activity. While blood cell (WBC), platelet (PLT), and red blood cell (RBC) counts were determined in summer (normothermia, June–July), fa...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology Vol. 60; no. 2; pp. 443 - 452
Main Authors: Teplova, P. O., Komelina, N. P., Yegorov, A. Ye, Lizorkina, K. I., Zakharova, N. M.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01.03.2024
Springer Nature B.V
Subjects:
Animal Physiology
Animals
Biochemistry
Biomedical and Life Sciences
Blood
Blood platelets
Body temperature
Erythrocytes
Evolutionary Biology
Experimental Papers
Flow velocity
Granulocytes
Heart
Hematology
Hemoglobin
Hibernation
Hypothermia
Hypoxia
Leukocytosis
Leukopenia
Life Sciences
Physiology
Platelets
Polycythemia
Rodents
Software
Statistical analysis
Summer
Thrombocytopenia
Thrombocytosis
Torpor
Winter
United States > US
China
hypoxia
hematology
physiological adaptation
hypothermia
ground squirrel
hemostasis
hibernation
ISSN:0022-0930, 1608-3202
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Summary:The complete blood count (CBC) dynamics was investigated in long-tailed ground squirrels Urocitellus undulatus ( n = 100) during different periods of their annual activity. While blood cell (WBC), platelet (PLT), and red blood cell (RBC) counts were determined in summer (normothermia, June–July), fall (preparatory period, October), winter torpor (hypothermia, December–February) and winter active (euthermia, interbout arousals, December–February) periods. In fall, PLT and WBC counts increased by ~40% compared to summer. Under winter torpor, thrombocytosis and leukocytosis were replaced by extreme thrombocytopenia (↓ ~90%), as well as leukopenia in all WBC subpopulations (↓ ~80%). During brief interbout arousals, PLT and WBC counts reached the summer values except for a slightly increased MPV (mean platelet volume). As fall approached, there was an insignificant erythrocytosis (↑ ~10%), which together with changes in other indices could have suggested a mild fall-time hypoxia. During winter torpid and euthermic periods, RBC counts were almost indistinguishable from the summer control values, however, atypical RBC forms occurred both in the fall preparatory period and during hibernation itself. The results are discussed in the context of blood cell adaptation to harsh conditions of hibernation in ground squirrels, and can be useful in studying the adaptive abilities of homoeotherms, including humans.
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ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093024020017