IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

Tumours maximize their chance of metastasizing by evoking a systemic inflammatory cascade in mouse models of spontaneous breast cancer metastasis. A novel cancer metastasis pathway That tumorigenesis can be closely linked to an inflammatory microenvironment has been well established. In a new study,...

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Bibliographic Details
Published in:	Nature (London) Vol. 522; no. 7556; pp. 345 - 348
Main Authors:	Coffelt, Seth B., Kersten, Kelly, Doornebal, Chris W., Weiden, Jorieke, Vrijland, Kim, Hau, Cheei-Sing, Verstegen, Niels J. M., Ciampricotti, Metamia, Hawinkels, Lukas J. A. C., Jonkers, Jos, de Visser, Karin E.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.06.2015
Subjects:	13/21 13/31 13/51 38/91 631/67/1347 631/67/322 631/67/327 631/67/580 64/60 Animals Breast Neoplasms - immunology Breast Neoplasms - pathology CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Disease Models, Animal Female Granulocyte Colony-Stimulating Factor - immunology Granulocyte Colony-Stimulating Factor - metabolism Humanities and Social Sciences Interleukin-17 - biosynthesis Interleukin-17 - immunology Interleukin-1beta - immunology letter Lung - pathology Lung Neoplasms - immunology Lung Neoplasms - pathology Lung Neoplasms - secondary Lymphatic Metastasis - immunology Lymphatic Metastasis - pathology Lymphocyte Activation Mice multidisciplinary Neoplasm Metastasis - immunology Neoplasm Metastasis - pathology Neutrophils - cytology Neutrophils - immunology Neutrophils - metabolism Phenotype Science T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Tumor Microenvironment
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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