The efficacy of vitamin C on postlaparoscopic shoulder pain: a double-blind randomized controlled trial
Background: This study evaluated the effect of vitamin C on post-laparoscopic shoulder pain (PLSP) in patients undergoing benign gynecological surgery during the first 72 h. Methods: Sixty patients (aged 20 to 60 years, with American Society of Anesthesiologists physical status classification I or I...
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| Published in: | Anesthesia and pain medicine (Korean society of anesthesiologists) Vol. 14; no. 2; pp. 202 - 207 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
대한마취통증의학회
01.04.2019
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| ISSN: | 1975-5171, 2383-7977 |
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| Abstract | Background: This study evaluated the effect of vitamin C on post-laparoscopic shoulder pain (PLSP) in patients undergoing benign gynecological surgery during the first 72 h.
Methods: Sixty patients (aged 20 to 60 years, with American Society of Anesthesiologists physical status classification I or II) scheduled for elective laparoscopic hysterectomy were enrolled in this study. The vitamin C group (Group C) received 500 mg of vitamin C in 50 ml of isotonic saline infusion intravenously twice a day from the day of surgery to the third day after surgery. Patients in the saline group (Group S) received the same volume of isotonic saline over the same period. Post-operative analgesic consumption, pain scores of the incision site and the shoulder, and the incidence of PLSP were all evaluated at 1, 6, 24, 48, and 72 h following surgery.
Results: Cumulative post-operative fentanyl consumption was significantly less in Group C at 24 and 48 h after surgery (P = 0.002, P = 0.012, respectively). The pain intensity of PLSP was also significantly lower in Group C 24 h after the operation (P = 0.002). Additionally, the incidence of PLSP was significantly lower in Group C 24 and 48 h after the operation (P = 0.002, P = 0.035, respectively).
Conclusions: Perioperative intravenous administration of vitamin C (500 mg, twice a day) reduced post-operative analgesic consumption and significantly lowered the pain intensity and incidence of PLSP. KCI Citation Count: 0 |
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| AbstractList | Background: This study evaluated the effect of vitamin C on post-laparoscopic shoulder pain (PLSP) in patients undergoing benign gynecological surgery during the first 72 h.
Methods: Sixty patients (aged 20 to 60 years, with American Society of Anesthesiologists physical status classification I or II) scheduled for elective laparoscopic hysterectomy were enrolled in this study. The vitamin C group (Group C) received 500 mg of vitamin C in 50 ml of isotonic saline infusion intravenously twice a day from the day of surgery to the third day after surgery. Patients in the saline group (Group S) received the same volume of isotonic saline over the same period. Post-operative analgesic consumption, pain scores of the incision site and the shoulder, and the incidence of PLSP were all evaluated at 1, 6, 24, 48, and 72 h following surgery.
Results: Cumulative post-operative fentanyl consumption was significantly less in Group C at 24 and 48 h after surgery (P = 0.002, P = 0.012, respectively). The pain intensity of PLSP was also significantly lower in Group C 24 h after the operation (P = 0.002). Additionally, the incidence of PLSP was significantly lower in Group C 24 and 48 h after the operation (P = 0.002, P = 0.035, respectively).
Conclusions: Perioperative intravenous administration of vitamin C (500 mg, twice a day) reduced post-operative analgesic consumption and significantly lowered the pain intensity and incidence of PLSP. KCI Citation Count: 0 |
| Author | Cho, Yong Hyun Cho, Kwangrae Lim, Se Hun Kim, Myoung-hun Lee, Wonjin Moon, Sungho |
| Author_xml | – sequence: 1 givenname: Sungho orcidid: 0000-0002-3602-9441 surname: Moon fullname: Moon, Sungho organization: Departments of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea – sequence: 2 givenname: Se Hun orcidid: 0000-0001-8450-0595 surname: Lim fullname: Lim, Se Hun organization: Departments of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea – sequence: 3 givenname: Kwangrae orcidid: 0000-0002-9805-9582 surname: Cho fullname: Cho, Kwangrae organization: Departments of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea – sequence: 4 givenname: Myoung-hun orcidid: 0000-0002-4350-0078 surname: Kim fullname: Kim, Myoung-hun organization: Departments of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea – sequence: 5 givenname: Wonjin orcidid: 0000-0002-6240-7370 surname: Lee fullname: Lee, Wonjin organization: Departments of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea – sequence: 6 givenname: Yong Hyun orcidid: 0000-0003-1334-3531 surname: Cho fullname: Cho, Yong Hyun organization: Departments of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea |
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| CitedBy_id | crossref_primary_10_3390_jcm14113994 crossref_primary_10_1038_s41598_022_08834_5 crossref_primary_10_3390_nu12103109 crossref_primary_10_1136_bmjopen_2022_069230 crossref_primary_10_1016_j_ijom_2022_06_005 crossref_primary_10_4103_ijpn_ijpn_87_24 crossref_primary_10_1371_journal_pone_0316450 crossref_primary_10_1016_j_bja_2021_11_039 crossref_primary_10_1007_s40122_024_00622_5 crossref_primary_10_3390_cells11121880 |
| Cites_doi | 10.1046/j.1365-2168.2000.01507.x 10.1016/S0001-2092(06)63296-1 10.1016/j.neulet.2005.02.032 10.1089/lap.2010.0112 10.1186/s12967-017-1179-7 10.1007/s12630-012-9692-x 10.1097/00001756-199011000-00004 10.1155/2016/9147279 10.1007/s00464-017-5651-5 10.1016/j.suc.2014.10.002 10.1016/j.pain.2004.06.008 10.7326/0003-4819-140-7-200404060-00010 10.1016/0301-0082(94)90052-3 10.1016/j.fas.2009.02.002 10.1007/s004649901011 10.5812/aapm.17366 10.1097/AOG.0b013e318283fcca 10.1016/j.ejogrb.2014.09.003 10.17085/apm.2016.11.3.236 10.1097/MCO.0b013e32833e05bc 10.1016/0006-8993(90)90379-P 10.1111/coa.12684 10.1073/pnas.93.8.3704 10.1016/j.jmig.2017.06.002 10.1213/00000539-199407000-00028 10.1016/j.jmig.2014.01.018 |
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