Development of a Hyperopia Animal Model Using Blue Light in Guinea Pigs

Purpose: Although numerous studies have investigated the progression of myopia, a reliable animal model for hyperopia remains undeveloped. This study aimed to evaluate whether blue light exposure can suppress emmetropization in a manner comparable to lens-induced hyperopia, thereby facilitating the...

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Vydáno v:Korean journal of ophthalmology Ročník 39; číslo 5; s. 410 - 417
Hlavní autoři: Yoo, Yung Ju, Hwang, Jeong-Min
Médium: Journal Article
Jazyk:angličtina
Vydáno: Korea (South) 대한안과학회 01.10.2025
Témata:
Animals
Blue Light
Disease Models, Animal
Guinea Pigs
Hyperopia - diagnosis
Hyperopia - etiology
Hyperopia - physiopathology
Light - adverse effects
Refraction, Ocular - physiology
Retinoscopy
안과학
Axial length
Blue light
Guinea pigs
Hyperopia
ISSN:1011-8942, 2092-9382, 2092-9382
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Shrnutí:Purpose: Although numerous studies have investigated the progression of myopia, a reliable animal model for hyperopia remains undeveloped. This study aimed to evaluate whether blue light exposure can suppress emmetropization in a manner comparable to lens-induced hyperopia, thereby facilitating the development of an experimental animal model of hyperopia.Methods: Five-day-old 24 guinea pigs were randomly assigned to four different experimental groups based on light exposure conditions. They were housed under a 12-hour light/dark cycle (lights on at 8 AM and off at 8 PM) and exposed to either white light (control) or blue light (460 ± 20 nm). To induce hyperopia, a custom-designed +10 diopters (D) lens was fabricated using a three-dimensional printer and securely attached to randomly selected one eye with hook-and-loop fasteners and tissue adhesive. Refractive errors, corneal curvature, and axial length were measured using streak retinoscopy and A-scan ultrasound, with repeated measurements to assess intereye deviation.Results: At the end of the treatment period of 6 weeks, guinea pigs reared under blue light with an attached +10 D lens exhibited a significantly greater hyperopic shift compared to those reared under blue light without the lens. In contrast, guinea pigs raised under white light underwent emmetropization regardless of +10 D lens attachment.Conclusions: Blue light exposure significantly suppressed emmetropization by inducing a marked hyperopic shift in guinea pigs, whereas white light conditions support normal emmetropization regardless of lens attachment. These findings suggest that blue light plays a crucial role in hyperopia induction and can be effectively utilized to establish a stable hyperopia animal model.
Bibliografie:ObjectType-Article-1
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ISSN:1011-8942
2092-9382
2092-9382
DOI:10.3341/kjo.2025.0100