Vitamin D deficiency: A simple algorithm employing weekly administration of 50,000IU of vitamin D

Vitamin D deficiency affects parathyroid hormone levels and is endemic in the American population due to diet and lifestyle. The aim of this study was to evaluate a treatment algorithm using weekly doses of 50,000IU of Vitamin D2 for thyroid and parathyroid surgery patients. Prospective, non-randomi...

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Vydáno v:American journal of otolaryngology Ročník 35; číslo 2; s. 85 - 88
Hlavní autoři: Middleton, Laura, Stack, Brendan C., Riggs, Ann T., Bodenner, Donald L.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Maryland Heights Elsevier Inc 01.03.2014
Elsevier Limited
Témata:
Algorithms
Bone density
Metabolism
Mortality
Older people
Studies
Surgery
Vitamin D
Vitamin deficiency
ISSN:0196-0709, 1532-818X
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Shrnutí:Vitamin D deficiency affects parathyroid hormone levels and is endemic in the American population due to diet and lifestyle. The aim of this study was to evaluate a treatment algorithm using weekly doses of 50,000IU of Vitamin D2 for thyroid and parathyroid surgery patients. Prospective, non-randomized. University health sciences center. Patients at a thyroid center being treated for benign and malignant thyroid diseases or parathyroid disease. Subjects with total vitamin D levels less than 30ng/dl were prospectively treated with weekly doses of 50,000IU of vitamin D2 (D2) for durations dependent upon initial vitamin D (25-hydroxyvitamin D) levels. Vitamin D levels were measured after the treatment intervals and change in levels from baseline was determined. Subjects receiving 8weeks of therapy demonstrated an average increase in vitamin D level of 13.4ng/ml, 10weeks of therapy showed an increase of 16.35ng/ml, and 12weeks showed an average increase of 21.6ng/ml. The treatment groups had success rates of 82%, 75%, and 71% after 8, 10, and 12weeks of therapy respectively. When only compliant patients were evaluated (defined as greater than 3-ng/ml increase after therapy), the success rates after 8, 10, and 12weeks increased to 95%, 79%, and 71% respectively. A simple algorithm using 50,000IU of vitamin D2 corrects its deficiency in the majority of subjects treated. This is a simple method of treatment for thyroid and parathyroid patients who are vitamin D deficient. Thyroid and parathyroid conditions are frequently treated by otolaryngologists and vitamin D deficiency can complicate their diagnosis and/or management.
Bibliografie:ObjectType-Article-1
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ISSN:0196-0709
1532-818X
DOI:10.1016/j.amjoto.2013.12.002