Vitamin D deficiency: A simple algorithm employing weekly administration of 50,000IU of vitamin D
Vitamin D deficiency affects parathyroid hormone levels and is endemic in the American population due to diet and lifestyle. The aim of this study was to evaluate a treatment algorithm using weekly doses of 50,000IU of Vitamin D2 for thyroid and parathyroid surgery patients. Prospective, non-randomi...
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| Published in: | American journal of otolaryngology Vol. 35; no. 2; pp. 85 - 88 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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| ISSN: | 0196-0709, 1532-818X |
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| Abstract | Vitamin D deficiency affects parathyroid hormone levels and is endemic in the American population due to diet and lifestyle. The aim of this study was to evaluate a treatment algorithm using weekly doses of 50,000IU of Vitamin D2 for thyroid and parathyroid surgery patients.
Prospective, non-randomized.
University health sciences center.
Patients at a thyroid center being treated for benign and malignant thyroid diseases or parathyroid disease. Subjects with total vitamin D levels less than 30ng/dl were prospectively treated with weekly doses of 50,000IU of vitamin D2 (D2) for durations dependent upon initial vitamin D (25-hydroxyvitamin D) levels. Vitamin D levels were measured after the treatment intervals and change in levels from baseline was determined.
Subjects receiving 8weeks of therapy demonstrated an average increase in vitamin D level of 13.4ng/ml, 10weeks of therapy showed an increase of 16.35ng/ml, and 12weeks showed an average increase of 21.6ng/ml. The treatment groups had success rates of 82%, 75%, and 71% after 8, 10, and 12weeks of therapy respectively. When only compliant patients were evaluated (defined as greater than 3-ng/ml increase after therapy), the success rates after 8, 10, and 12weeks increased to 95%, 79%, and 71% respectively.
A simple algorithm using 50,000IU of vitamin D2 corrects its deficiency in the majority of subjects treated. This is a simple method of treatment for thyroid and parathyroid patients who are vitamin D deficient. Thyroid and parathyroid conditions are frequently treated by otolaryngologists and vitamin D deficiency can complicate their diagnosis and/or management. |
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| AbstractList | Vitamin D deficiency affects parathyroid hormone levels and is endemic in the American population due to diet and lifestyle. The aim of this study was to evaluate a treatment algorithm using weekly doses of 50,000IU of Vitamin D2 for thyroid and parathyroid surgery patients.
Prospective, non-randomized.
University health sciences center.
Patients at a thyroid center being treated for benign and malignant thyroid diseases or parathyroid disease. Subjects with total vitamin D levels less than 30ng/dl were prospectively treated with weekly doses of 50,000IU of vitamin D2 (D2) for durations dependent upon initial vitamin D (25-hydroxyvitamin D) levels. Vitamin D levels were measured after the treatment intervals and change in levels from baseline was determined.
Subjects receiving 8weeks of therapy demonstrated an average increase in vitamin D level of 13.4ng/ml, 10weeks of therapy showed an increase of 16.35ng/ml, and 12weeks showed an average increase of 21.6ng/ml. The treatment groups had success rates of 82%, 75%, and 71% after 8, 10, and 12weeks of therapy respectively. When only compliant patients were evaluated (defined as greater than 3-ng/ml increase after therapy), the success rates after 8, 10, and 12weeks increased to 95%, 79%, and 71% respectively.
A simple algorithm using 50,000IU of vitamin D2 corrects its deficiency in the majority of subjects treated. This is a simple method of treatment for thyroid and parathyroid patients who are vitamin D deficient. Thyroid and parathyroid conditions are frequently treated by otolaryngologists and vitamin D deficiency can complicate their diagnosis and/or management. Objective Vitamin D deficiency affects parathyroid hormone levels and is endemic in the American population due to diet and lifestyle. The aim of this study was to evaluate a treatment algorithm using weekly doses of 50,000IU of Vitamin D2for thyroid and parathyroid surgery patients. Study Design Prospective, non-randomized. Setting University health sciences center. Subjects and Methods Patients at a thyroid center being treated for benign and malignant thyroid diseases or parathyroid disease. Subjects with total vitamin D levels less than 30ng/dl were prospectively treated with weekly doses of 50,000IU of vitamin D2(D2) for durations dependent upon initial vitamin D (25-hydroxyvitamin D) levels. Vitamin D levels were measured after the treatment intervals and change in levels from baseline was determined. Results Subjects receiving 8weeks of therapy demonstrated an average increase in vitamin D level of 13.4ng/ml, 10weeks of therapy showed an increase of 16.35ng/ml, and 12weeks showed an average increase of 21.6ng/ml. The treatment groups had success rates of 82%, 75%, and 71% after 8, 10, and 12weeks of therapy respectively. When only compliant patients were evaluated (defined as greater than 3-ng/ml increase after therapy), the success rates after 8, 10, and 12weeks increased to 95%, 79%, and 71% respectively. Conclusions A simple algorithm using 50,000IU of vitamin D2corrects its deficiency in the majority of subjects treated. This is a simple method of treatment for thyroid and parathyroid patients who are vitamin D deficient. Thyroid and parathyroid conditions are frequently treated by otolaryngologists and vitamin D deficiency can complicate their diagnosis and/or management. |
| Author | Riggs, Ann T. Bodenner, Donald L. Stack, Brendan C. Middleton, Laura |
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| Cites_doi | 10.1001/jama.2010.594 10.1093/ajcn/86.3.645 10.1111/j.1532-5415.2007.01048.x 10.1017/S136898001100022X 10.1210/jc.2011-0385 10.4158/EP.15.2.95 10.1210/jc.2007-0239 10.1016/j.jamda.2006.09.015 10.1210/jc.2004-2364 10.1016/j.amjopharm.2007.03.005 10.1210/jc.2006-1404 10.1001/archinte.167.16.1730 10.1056/NEJMra070553 10.1210/jc.2007-2308 10.1007/s00198-005-1867-7 10.5694/j.1326-5377.2005.tb06879.x 10.1093/ajcn/88.2.537S |
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