Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health

Mental disorders are increasingly understood as disorders of brain development. Large and heterogeneous samples are required to define generalizable links between brain development and psychopathology. To this end, we introduce Reproducible Brain Charts (RBC), an open resource that integrates data f...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Jg. 113; H. 22; S. 3758
Hauptverfasser: Shafiei, Golia, Esper, Nathalia B, Hoffmann, Mauricio S, Ai, Lei, Chen, Andrew A, Cluce, Jon, Covitz, Sydney, Giavasis, Steven, Lane, Connor, Mehta, Kahini, Moore, Tyler M, Salo, Taylor, Tapera, Tinashe M, Calkins, Monica E, Colcombe, Stanley, Davatzikos, Christos, Gur, Raquel E, Gur, Ruben C, Pan, Pedro M, Jackowski, Andrea P, Rokem, Ariel, Rohde, Luis A, Shinohara, Russell T, Tottenham, Nim, Zuo, Xi-Nian, Cieslak, Matthew, Franco, Alexandre R, Kiar, Gregory, Salum, Giovanni A, Milham, Michael P, Satterthwaite, Theodore D
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 19.11.2025
Schlagworte:
Adolescent
Brain - diagnostic imaging
Brain - growth & development
Brain Mapping - methods
Child
Databases, Factual
Female
Humans
Information Dissemination
Magnetic Resonance Imaging
Male
Mental Disorders - diagnostic imaging
Mental Health
Neuroimaging
Reproducibility of Results
fMRI
open science
QC
RBC
structural MRI
neurodevelopment
quality control
MRI
psychopathology
data harmonization
reproducible neuroscience
Reproducible Brain Charts
ISSN:1097-4199, 1097-4199
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Beschreibung
Zusammenfassung:Mental disorders are increasingly understood as disorders of brain development. Large and heterogeneous samples are required to define generalizable links between brain development and psychopathology. To this end, we introduce Reproducible Brain Charts (RBC), an open resource that integrates data from 5 large studies of brain development in youth from three continents (N = 6,346). Bifactor models were used to create harmonized psychiatric phenotypes, capturing major dimensions of psychopathology. Following rigorous quality assurance, neuroimaging data were carefully curated and processed using consistent pipelines in a reproducible manner. Initial analyses of RBC emphasize the benefit of careful quality assurance and data harmonization in delineating developmental effects and associations with psychopathology. Critically, all RBC data-including harmonized psychiatric phenotypes, unprocessed images, and fully processed imaging derivatives-are openly shared without a data use agreement via the International Neuroimaging Data-sharing Initiative. Together, RBC facilitates large-scale, reproducible, and generalizable research in developmental and psychiatric neuroscience.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1097-4199
1097-4199
DOI:10.1016/j.neuron.2025.08.026