Diacerein attenuates sepsis shock mortality through combined suppression of vascular inflammation, stiffness, and permeability

Sepsis shock mortality remains critically high due to dysregulated vascular inflammation and permeability. Diacerein (DIA), an anthraquinone derivative with anti-inflammatory properties, shows promise, but its vascular protective mechanisms in sepsis are unclear. This study investigated DIA's e...

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Bibliographic Details
Published in:	Phytomedicine (Stuttgart) Vol. 149; p. 157510
Main Authors:	Luo, Minghao, Jiang, Yi, Peng, Yuce, Lv, Dingyi, He, An, Huang, Longxiang, Xia, Yong, Luo, Suxin, Li, Yuanjing
Format:	Journal Article
Language:	English
Published:	Germany Elsevier GmbH 01.12.2025
Subjects:	Animals Anthraquinones - pharmacology Anti-Inflammatory Agents - pharmacology Bulk-RNA sequencing Capillary Permeability - drug effects Cytokines - blood Diacerein Disease Models, Animal Inflammation - drug therapy Male Mice Mice, Inbred C57BL NF-κB Septic shock Shock, Septic - drug therapy Shock, Septic - mortality STAT2 Vascular Stiffness - drug effects NF-κB Septic shock Bulk-RNA sequencing STAT2 Diacerein
ISSN:	0944-7113, 1618-095X, 1618-095X
Online Access:	Get full text
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