A systematic review and meta-analysis of double trophectoderm biopsy and/or cryopreservation in PGT: balancing the need for a diagnosis against the risk of harm

To prevent the transfer of embryos affected by monogenic conditions and/or chromosomal defects, preimplantation genetic testing (PGT) requires trophectoderm biopsy and cryopreservation. In 2-6% of biopsies, the diagnosis may be inconclusive due to DNA amplification failure or low-quality results. In...

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Bibliographic Details
Published in:	Human reproduction update Vol. 31; no. 2; p. 102
Main Authors:	Li Piani, Letizia, Petrone, Pasquale, Brutto, Mariafrancesca, De Vos, Anick, Van Der Kelen, Annelore, Vaiarelli, Alberto, Rienzi, Laura, Conforti, Alessandro, Cimadomo, Danilo, Verpoest, Willem
Format:	Journal Article
Language:	English
Published:	England 01.03.2025
Subjects:	Abortion, Spontaneous Biopsy - adverse effects Biopsy - methods Cryopreservation - methods Embryo Transfer Female Genetic Testing - methods Humans Pregnancy Pregnancy Outcome Pregnancy Rate Preimplantation Diagnosis - adverse effects Preimplantation Diagnosis - methods biopsy inconclusive diagnosis PGT safety vitrification
ISSN:	1460-2369, 1460-2369
Online Access:	Get more information
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