Improved glycemic control of children and youth with type 1 diabetes in Iceland in 2008-2022
Introduction: Type 1 diabetes is characterized by destruction of the insulin-producing beta cells causing hyperglycemia. Insulin treatment targeting euglycemia mitigates complications. This study aims to assess glycemic control in Icelandic children with diabetes over the past 14 years and examine t...
Gespeichert in:
| Veröffentlicht in: | Laeknabladid Jg. 111; H. 3; S. 112 - 117 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Isländisch |
| Veröffentlicht: |
Iceland
01.03.2025
|
| Schlagworte: | |
| ISSN: | 0023-7213, 1670-4959, 1670-4959 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Introduction: Type 1 diabetes is characterized by destruction of the insulin-producing beta cells causing hyperglycemia. Insulin treatment targeting euglycemia mitigates complications. This study aims to assess glycemic control in Icelandic children with diabetes over the past 14 years and examine the impact of a semi-automatic insulin pump. Methods: The study included Icelandic pediatric patients with type 1 diabetes from the past 14 years. Data on HbA1c, date of diagnosis, co-occurring diagnoses, sex, age, number of ketoacidosis diagnoses, and the introduction of a semi-automatic insulin pump were gathered from medical records. Results: The average of means HbA1c peaked in 2012 at 70,4±11,3 mmol/mol and had its nadir in 2022 at 59,5±11,2 mmol/mol. The proportion of children with HbA1c over 70 mmol/mol was highest in 2011 (51.8%) and lowest in 2022 (10.2%). Females had higher HbA1c levels, the difference decreased by the end of the study period. Mean HbA1c decreased by 6.4 mmol/mol 18 months after introduction of a semi-automatic insulin pump. There was no significant change in mean HbA1c when 18 months prior and post introduction were compared. No change in incidence was observed over the period. Between 2018-2023, 11.2% had hypothyroidism, 2.2% had celiac disease, and 29 cases of ketoacidosis were diagnosed. Discussion: Significant progress has been made in treating Icelandic children with type 1 diabetes in recent years. There was no increase in incidence, contrary to other studies. The impact of the semi-automatic insulin pump was less pronounced than in other studies, possibly due to a longer follow-up period. |
|---|---|
| AbstractList | Type 1 diabetes is characterized by destruction of the insulin-producing beta cells causing hyperglycemia. Insulin treatment targeting euglycemia mitigates complications. This study aims to assess glycemic control in Icelandic children with diabetes over the past 14 years and examine the impact of a semi-automatic insulin pump.INTRODUCTIONType 1 diabetes is characterized by destruction of the insulin-producing beta cells causing hyperglycemia. Insulin treatment targeting euglycemia mitigates complications. This study aims to assess glycemic control in Icelandic children with diabetes over the past 14 years and examine the impact of a semi-automatic insulin pump.The study included Icelandic pediatric patients with type 1 diabetes from the past 14 years. Data on HbA1c, date of diagnosis, co-occurring diagnoses, sex, age, number of ketoacidosis diagnoses, and the introduction of a semi-automatic insulin pump were gathered from medical records.METHODSThe study included Icelandic pediatric patients with type 1 diabetes from the past 14 years. Data on HbA1c, date of diagnosis, co-occurring diagnoses, sex, age, number of ketoacidosis diagnoses, and the introduction of a semi-automatic insulin pump were gathered from medical records.The average of means HbA1c peaked in 2012 at 70,4±11,3 mmol/mol and had its nadir in 2022 at 59,5±11,2 mmol/mol. The proportion of children with HbA1c over 70 mmol/mol was highest in 2011 (51.8%) and lowest in 2022 (10.2%). Females had higher HbA1c levels, the difference decreased by the end of the study period. Mean HbA1c decreased by 6.4 mmol/mol 18 months after introduction of a semi-automatic insulin pump. There was no significant change in mean HbA1c when 18 months prior and post introduction were compared. No change in incidence was observed over the period. Between 2018-2023, 11.2% had hypothyroidism, 2.2% had celiac disease, and 29 cases of ketoacidosis were diagnosed.RESULTSThe average of means HbA1c peaked in 2012 at 70,4±11,3 mmol/mol and had its nadir in 2022 at 59,5±11,2 mmol/mol. The proportion of children with HbA1c over 70 mmol/mol was highest in 2011 (51.8%) and lowest in 2022 (10.2%). Females had higher HbA1c levels, the difference decreased by the end of the study period. Mean HbA1c decreased by 6.4 mmol/mol 18 months after introduction of a semi-automatic insulin pump. There was no significant change in mean HbA1c when 18 months prior and post introduction were compared. No change in incidence was observed over the period. Between 2018-2023, 11.2% had hypothyroidism, 2.2% had celiac disease, and 29 cases of ketoacidosis were diagnosed.Significant progress has been made in treating Icelandic children with type 1 diabetes in recent years. There was no increase in incidence, contrary to other studies. The impact of the semi-automatic insulin pump was less pronounced than in other studies, possibly due to a longer follow-up period.DISCUSSIONSignificant progress has been made in treating Icelandic children with type 1 diabetes in recent years. There was no increase in incidence, contrary to other studies. The impact of the semi-automatic insulin pump was less pronounced than in other studies, possibly due to a longer follow-up period. Type 1 diabetes is characterized by destruction of the insulin-producing beta cells causing hyperglycemia. Insulin treatment targeting euglycemia mitigates complications. This study aims to assess glycemic control in Icelandic children with diabetes over the past 14 years and examine the impact of a semi-automatic insulin pump. The study included Icelandic pediatric patients with type 1 diabetes from the past 14 years. Data on HbA1c, date of diagnosis, co-occurring diagnoses, sex, age, number of ketoacidosis diagnoses, and the introduction of a semi-automatic insulin pump were gathered from medical records. The average of means HbA1c peaked in 2012 at 70,4±11,3 mmol/mol and had its nadir in 2022 at 59,5±11,2 mmol/mol. The proportion of children with HbA1c over 70 mmol/mol was highest in 2011 (51.8%) and lowest in 2022 (10.2%). Females had higher HbA1c levels, the difference decreased by the end of the study period. Mean HbA1c decreased by 6.4 mmol/mol 18 months after introduction of a semi-automatic insulin pump. There was no significant change in mean HbA1c when 18 months prior and post introduction were compared. No change in incidence was observed over the period. Between 2018-2023, 11.2% had hypothyroidism, 2.2% had celiac disease, and 29 cases of ketoacidosis were diagnosed. Significant progress has been made in treating Icelandic children with type 1 diabetes in recent years. There was no increase in incidence, contrary to other studies. The impact of the semi-automatic insulin pump was less pronounced than in other studies, possibly due to a longer follow-up period. Introduction: Type 1 diabetes is characterized by destruction of the insulin-producing beta cells causing hyperglycemia. Insulin treatment targeting euglycemia mitigates complications. This study aims to assess glycemic control in Icelandic children with diabetes over the past 14 years and examine the impact of a semi-automatic insulin pump. Methods: The study included Icelandic pediatric patients with type 1 diabetes from the past 14 years. Data on HbA1c, date of diagnosis, co-occurring diagnoses, sex, age, number of ketoacidosis diagnoses, and the introduction of a semi-automatic insulin pump were gathered from medical records. Results: The average of means HbA1c peaked in 2012 at 70,4±11,3 mmol/mol and had its nadir in 2022 at 59,5±11,2 mmol/mol. The proportion of children with HbA1c over 70 mmol/mol was highest in 2011 (51.8%) and lowest in 2022 (10.2%). Females had higher HbA1c levels, the difference decreased by the end of the study period. Mean HbA1c decreased by 6.4 mmol/mol 18 months after introduction of a semi-automatic insulin pump. There was no significant change in mean HbA1c when 18 months prior and post introduction were compared. No change in incidence was observed over the period. Between 2018-2023, 11.2% had hypothyroidism, 2.2% had celiac disease, and 29 cases of ketoacidosis were diagnosed. Discussion: Significant progress has been made in treating Icelandic children with type 1 diabetes in recent years. There was no increase in incidence, contrary to other studies. The impact of the semi-automatic insulin pump was less pronounced than in other studies, possibly due to a longer follow-up period. |
| Author | Jonsdottir, Berglind Bjarnason, Ragnar Hansen, Jakob Konradsdottir, Elisabet |
| Author_xml | – sequence: 1 givenname: Jakob surname: Hansen fullname: Hansen, Jakob – sequence: 2 givenname: Elisabet surname: Konradsdottir fullname: Konradsdottir, Elisabet – sequence: 3 givenname: Ragnar surname: Bjarnason fullname: Bjarnason, Ragnar – sequence: 4 givenname: Berglind surname: Jonsdottir fullname: Jonsdottir, Berglind |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40013447$$D View this record in MEDLINE/PubMed |
| BookMark | eNo9kD1PwzAQhi1UREvpzoQ8siScP2LHI6r4qITEAhuSldgODUriEieg_HtcWrjh7oZHp_eeczTrfOcQuiSQEqkUvWnKJqVAsxRYmjM4QQsiJCRcZWqGFgCUJZISNkerED4glgCilDxDcw5AGOdygd427a73X87i92Yyrq0NNr4bet9gX2GzrRvbuw4XncWTH4ct_q5jG6adwwTbuijd4AKuO7wxrtlTcaUAeRKD0Qt0WhVNcKvjXKLX-7uX9WPy9PywWd8-JYZSPiRlJqR0UnJlK8UzsMIY6QQriFCVIsxRIJKXxgpSZvFfIwppmeFFVQimqowt0fXhbnzlc3Rh0G0dYp4YyPkxaEYkyfNMChbRqyM6lq2zetfXbdFP-s9IBOAAmN6H0LvqHyGgf73r6F3vvWtgOnpnP5QYcsE |
| ContentType | Journal Article |
| CorporateAuthor | Faculty of Medicine, Department of Health Sciences, University of Iceland, Department of Pediatrics, National University Hospital of Iceland, Reykjavik |
| CorporateAuthor_xml | – name: Faculty of Medicine, Department of Health Sciences, University of Iceland, Department of Pediatrics, National University Hospital of Iceland, Reykjavik |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.17992/lbl.2025.03.830 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1670-4959 |
| EndPage | 117 |
| ExternalDocumentID | 40013447 10_17992_lbl_2025_03_830 |
| Genre | English Abstract Journal Article |
| GeographicLocations | Iceland |
| GeographicLocations_xml | – name: Iceland |
| GroupedDBID | 5GY 5VS AAYXX AENEX ALMA_UNASSIGNED_HOLDINGS CITATION DIK F5P GROUPED_DOAJ OK1 CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c224t-b5677e7749df9450d6cc7e63a169f913e20174bcd61b5025c6a7d3c4afa639f53 |
| ISICitedReferencesCount | 0 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001495004000004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0023-7213 1670-4959 |
| IngestDate | Fri Jul 11 00:01:03 EDT 2025 Sun May 11 01:40:41 EDT 2025 Sat Nov 29 08:10:29 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | Glycemic control Pediatrics Semi-automatic insulin pump Type 1 diabetes |
| Language | Icelandic |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c224t-b5677e7749df9450d6cc7e63a169f913e20174bcd61b5025c6a7d3c4afa639f53 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| OpenAccessLink | https://www.laeknabladid.is/media/2025-03/f02.pdf |
| PMID | 40013447 |
| PQID | 3171885763 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_3171885763 pubmed_primary_40013447 crossref_primary_10_17992_lbl_2025_03_830 |
| PublicationCentury | 2000 |
| PublicationDate | 2025-Mar |
| PublicationDateYYYYMMDD | 2025-03-01 |
| PublicationDate_xml | – month: 03 year: 2025 text: 2025-Mar |
| PublicationDecade | 2020 |
| PublicationPlace | Iceland |
| PublicationPlace_xml | – name: Iceland |
| PublicationTitle | Laeknabladid |
| PublicationTitleAlternate | Laeknabladid |
| PublicationYear | 2025 |
| SSID | ssj0000601997 |
| Score | 2.3052416 |
| Snippet | Introduction: Type 1 diabetes is characterized by destruction of the insulin-producing beta cells causing hyperglycemia. Insulin treatment targeting euglycemia... Type 1 diabetes is characterized by destruction of the insulin-producing beta cells causing hyperglycemia. Insulin treatment targeting euglycemia mitigates... |
| SourceID | proquest pubmed crossref |
| SourceType | Aggregation Database Index Database |
| StartPage | 112 |
| SubjectTerms | Adolescent Age Factors Biomarkers - blood Blood Glucose - drug effects Blood Glucose - metabolism Child Child, Preschool Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - epidemiology Diabetic Ketoacidosis - epidemiology Female Glycated Hemoglobin - metabolism Glycemic Control - trends Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - adverse effects Iceland - epidemiology Insulin - administration & dosage Insulin - adverse effects Insulin Infusion Systems Male Retrospective Studies Time Factors Treatment Outcome |
| Title | Improved glycemic control of children and youth with type 1 diabetes in Iceland in 2008-2022 |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/40013447 https://www.proquest.com/docview/3171885763 |
| Volume | 111 |
| WOSCitedRecordID | wos001495004000004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1670-4959 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000601997 issn: 0023-7213 databaseCode: DOA dateStart: 20000101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1La9wwEBabtJReSt_dPoIKvZRg6pck69iWljaQJYcU9lAwsiQv2yzesLsJyT_Kz8yMJdne0EBz6EV4DR5bmm9HM6NvJEI-8FTXtWQs4nFVRLnKWCRFUkWigD8T45VhqW4PmxCTSTGdyqPR6CrUwpwvRNMUFxfy9L-qGu6BsrF09g7q7oTCDbgGpUMLaof2nxTv0gTgR84Wl7qlvgc6OjLIQ-025ssv8fi8QSY26TOx82b_p7YLtzXTfsteSGNX2ttXT9sTLLxSJpDi0Y41PqNzoE6WVWfN8QwDs4YAeDNfeTLZGt_UJQP-KOhYqPVXs0Z1nOEDGKf-wS92NQPH2AyTFSnr2Vpd8UAWQdDpbJp1NpeLOII4TW4Z5SQZoC8bmNjE066t_yX-OhEIKXFn2UWFy0spw41sC78AtLXn9o25sGMoYmyEMkqQUKKEMs5KkLBD7qWCSTkI3t2cHyNjx_GJXA_9mjgK-XTjM7Z9oFsCm9bBOX5MHvnIhH52iHpCRrZ5Sh4ceu7FM_I7AIsGYFEPLLqsaQAWBcjQFlgUgUURWDShAVh03lAPLLzsgPWc_Pr-7fjrj8ifzRFpcPo2UcW4EBZiB2lqmbPYcK2F5ZlKuKxlkllwLEVeacOTikHPNVfCZDpXtQKfuGbZC7LbLBv7ilCua65Ynhobg6sET4OTq2OmFK8yY2o7Jh_DaJWnbguW8jb1jMn7MJwl2Elc_FKNXZ6tS_CTk6KA6Dobk5dunDtpOQZCeS5e3-FNb8jDHuBvye5mdWbfkfv6fDNfr_bIjpgWey1GoJ0cHV4D_kaQpA |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Improved+glycemic+control+of+children+and+youth+with+type+1+diabetes+in+Iceland+in+2008-2022&rft.jtitle=Laeknabladid&rft.au=Hansen%2C+Jakob&rft.au=Konradsdottir%2C+Elisabet&rft.au=Bjarnason%2C+Ragnar&rft.au=Jonsdottir%2C+Berglind&rft.date=2025-03-01&rft.issn=0023-7213&rft.eissn=1670-4959&rft.volume=111&rft.issue=3&rft.spage=112&rft.epage=117&rft_id=info:doi/10.17992%2Flbl.2025.03.830&rft.externalDBID=n%2Fa&rft.externalDocID=10_17992_lbl_2025_03_830 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0023-7213&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0023-7213&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0023-7213&client=summon |