The multilayered regulation of aromatic amino acid biosynthesis in plants
Plants commit large amounts of carbon and energy to the biosynthesis of aromatic amino acids (AAAs), because these molecules are precursors to a multitude of natural chemicals and polymers that are crucial for plant adaptation to the environment.The biosynthesis of AAAs starts with the shikimate pat...
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| Veröffentlicht in: | Trends in biochemical sciences (Amsterdam. Regular ed.) |
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| Sprache: | Englisch |
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Elsevier Ltd
26.08.2025
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| ISSN: | 0968-0004 |
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| Abstract | Plants commit large amounts of carbon and energy to the biosynthesis of aromatic amino acids (AAAs), because these molecules are precursors to a multitude of natural chemicals and polymers that are crucial for plant adaptation to the environment.The biosynthesis of AAAs starts with the shikimate pathway, which produces chorismate from phosphoenolpyruvate and erythrose-4-phosphate. Then, the biosynthesis of tryptophan and of phenylalanine and tyrosine from chorismate proceed via different pathways.Plants have multiple mechanisms to regulate key enzymes in the AAA biosynthetic pathway. These regulatory mechanisms are more complex than in other AAA-producing organisms, such as bacteria and yeast, allowing plants to precisely control AAA biosynthesis depending on the environment, tissue type, and other factors.Understanding the regulation of key AAA biosynthetic enzymes has allowed us to unlock the regulation of this pathway and generate engineered plants that overproduce AAAs. These engineered plants provide a promising chassis to sustainably produce useful AAA-derived chemicals in planta.
The shikimate and aromatic amino acid (AAA) biosynthetic pathways are crucial for the production of L-phenylalanine (Phe), L-tyrosine (Tyr), and L-tryptophan (Trp), as well as vitamins, hormones, and an array of plant natural products, including lignin, a major reservoir of organic carbon on Earth. In this review, we summarize recent advances in the mechanisms that dynamically regulate multiple enzymatic isoforms in plant AAA biosynthetic pathways, with a particular focus on Phe biosynthesis due to its central role as a precursor to phenylpropanoids. The integration of AAA biosynthesis with upstream and downstream plant metabolism is also discussed, as well as how this fundamental knowledge can inform the bioengineering of plant-based platforms for sustainable production of AAA-derived natural products.
The shikimate and aromatic amino acid (AAA) biosynthetic pathways are crucial for the production of L-phenylalanine (Phe), L-tyrosine (Tyr), and L-tryptophan (Trp), as well as vitamins, hormones, and an array of plant natural products, including lignin, a major reservoir of organic carbon on Earth. In this review, we summarize recent advances in the mechanisms that dynamically regulate multiple enzymatic isoforms in plant AAA biosynthetic pathways, with a particular focus on Phe biosynthesis due to its central role as a precursor to phenylpropanoids. The integration of AAA biosynthesis with upstream and downstream plant metabolism is also discussed, as well as how this fundamental knowledge can inform the bioengineering of plant-based platforms for sustainable production of AAA-derived natural products. |
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| AbstractList | Plants commit large amounts of carbon and energy to the biosynthesis of aromatic amino acids (AAAs), because these molecules are precursors to a multitude of natural chemicals and polymers that are crucial for plant adaptation to the environment.The biosynthesis of AAAs starts with the shikimate pathway, which produces chorismate from phosphoenolpyruvate and erythrose-4-phosphate. Then, the biosynthesis of tryptophan and of phenylalanine and tyrosine from chorismate proceed via different pathways.Plants have multiple mechanisms to regulate key enzymes in the AAA biosynthetic pathway. These regulatory mechanisms are more complex than in other AAA-producing organisms, such as bacteria and yeast, allowing plants to precisely control AAA biosynthesis depending on the environment, tissue type, and other factors.Understanding the regulation of key AAA biosynthetic enzymes has allowed us to unlock the regulation of this pathway and generate engineered plants that overproduce AAAs. These engineered plants provide a promising chassis to sustainably produce useful AAA-derived chemicals in planta.
The shikimate and aromatic amino acid (AAA) biosynthetic pathways are crucial for the production of L-phenylalanine (Phe), L-tyrosine (Tyr), and L-tryptophan (Trp), as well as vitamins, hormones, and an array of plant natural products, including lignin, a major reservoir of organic carbon on Earth. In this review, we summarize recent advances in the mechanisms that dynamically regulate multiple enzymatic isoforms in plant AAA biosynthetic pathways, with a particular focus on Phe biosynthesis due to its central role as a precursor to phenylpropanoids. The integration of AAA biosynthesis with upstream and downstream plant metabolism is also discussed, as well as how this fundamental knowledge can inform the bioengineering of plant-based platforms for sustainable production of AAA-derived natural products.
The shikimate and aromatic amino acid (AAA) biosynthetic pathways are crucial for the production of L-phenylalanine (Phe), L-tyrosine (Tyr), and L-tryptophan (Trp), as well as vitamins, hormones, and an array of plant natural products, including lignin, a major reservoir of organic carbon on Earth. In this review, we summarize recent advances in the mechanisms that dynamically regulate multiple enzymatic isoforms in plant AAA biosynthetic pathways, with a particular focus on Phe biosynthesis due to its central role as a precursor to phenylpropanoids. The integration of AAA biosynthesis with upstream and downstream plant metabolism is also discussed, as well as how this fundamental knowledge can inform the bioengineering of plant-based platforms for sustainable production of AAA-derived natural products. The shikimate and aromatic amino acid (AAA) biosynthetic pathways are crucial for the production of L-phenylalanine (Phe), L-tyrosine (Tyr), and L-tryptophan (Trp), as well as vitamins, hormones, and an array of plant natural products, including lignin, a major reservoir of organic carbon on Earth. In this review, we summarize recent advances in the mechanisms that dynamically regulate the AAA biosynthetic pathways of plants, with a particular focus on Phe biosynthesis due to its central role as a precursor to phenylpropanoids. The integration of AAA biosynthesis with upstream and downstream plant metabolism is also discussed, as well as how this fundamental knowledge can inform the bioengineering of plant-based platforms for sustainable production of AAA-derived natural products. The shikimate and aromatic amino acid (AAA) biosynthetic pathways are crucial for the production of L-phenylalanine (Phe), L-tyrosine (Tyr), and L-tryptophan (Trp), as well as vitamins, hormones, and an array of plant natural products, including lignin, a major reservoir of organic carbon on Earth. In this review, we summarize recent advances in the mechanisms that dynamically regulate the AAA biosynthetic pathways of plants, with a particular focus on Phe biosynthesis due to its central role as a precursor to phenylpropanoids. The integration of AAA biosynthesis with upstream and downstream plant metabolism is also discussed, as well as how this fundamental knowledge can inform the bioengineering of plant-based platforms for sustainable production of AAA-derived natural products.The shikimate and aromatic amino acid (AAA) biosynthetic pathways are crucial for the production of L-phenylalanine (Phe), L-tyrosine (Tyr), and L-tryptophan (Trp), as well as vitamins, hormones, and an array of plant natural products, including lignin, a major reservoir of organic carbon on Earth. In this review, we summarize recent advances in the mechanisms that dynamically regulate the AAA biosynthetic pathways of plants, with a particular focus on Phe biosynthesis due to its central role as a precursor to phenylpropanoids. The integration of AAA biosynthesis with upstream and downstream plant metabolism is also discussed, as well as how this fundamental knowledge can inform the bioengineering of plant-based platforms for sustainable production of AAA-derived natural products. |
| Author | El-Azaz, Jorge Maeda, Hiroshi A. |
| Author_xml | – sequence: 1 givenname: Jorge surname: El-Azaz fullname: El-Azaz, Jorge email: elazazciudad@wisc.edu organization: Department of Botany, University of Wisconsin, Madison, WI 53706, USA – sequence: 2 givenname: Hiroshi A. surname: Maeda fullname: Maeda, Hiroshi A. email: maeda2@wisc.edu organization: Department of Botany, University of Wisconsin, Madison, WI 53706, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40866156$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1099/13500872-142-8-1973 10.1021/bi060366+ 10.1007/s11103-006-9023-0 10.1093/pcp/pcad130 10.1016/j.molp.2014.11.001 10.1074/jbc.RA118.006539 10.1111/j.1365-313X.2009.04042.x 10.1111/nph.19730 10.1111/pbi.70004 10.1093/jxb/erw184 10.1111/tpj.14169 10.1074/jbc.RA120.012605 10.1016/j.pbi.2022.102201 10.1104/pp.93.2.758 10.1111/nph.14822 10.3389/fmicb.2021.692986 10.1111/j.1399-3054.1986.tb01251.x 10.1039/D0CC08078K 10.1105/tpc.109.073171 10.1111/tpj.15467 10.1126/science.1241602 10.1111/jipb.13054 10.1111/j.1399-3054.1992.tb04675.x 10.1016/j.jmb.2011.11.037 10.1111/j.1469-8137.2012.04052.x 10.3389/fpls.2019.01268 10.3389/fpls.2013.00062 10.3109/10409239009090615 10.1111/nph.16071 10.1093/jxb/erm059 10.1111/tpj.15590 10.1074/jbc.M702662200 10.1007/s11427-024-2567-4 10.1111/tpj.17105 10.3389/fpls.2015.00538 10.1111/pbi.13202 10.1105/tpc.112.102574 10.1038/ncomms7659 10.1007/s004250050489 10.1038/nchembio.1178 10.1093/jxb/erae077 10.1007/s007260170041 10.1111/j.1365-313X.2009.04040.x 10.1038/s41467-018-07969-2 10.1038/s41477-022-01272-1 10.1104/pp.002626 10.3389/fpls.2020.604349 10.1111/tpj.13989 10.1111/pbi.12854 10.1002/pld3.70037 10.1074/jbc.M114.558536 10.3390/ijms232415964 10.1093/plcell/koaa042 10.1038/s41477-024-01791-z 10.1111/tpj.13990 10.1038/ncomms3833 10.1016/j.molp.2015.09.005 10.1093/plcell/koaf067 10.1016/j.febslet.2009.02.017 10.1146/annurev.arplant.54.031902.134938 10.1038/nplants.2016.50 10.1093/jxb/eraa099 10.1038/ncomms9635 10.1186/s13068-018-1257-y 10.1074/jbc.M111.322164 10.1105/tpc.110.078824 10.1104/pp.108.130070 10.1016/j.jtbi.2018.11.005 10.3390/plants12020266 10.3390/cells10061547 10.1016/j.pbi.2022.102219 10.1002/pld3.218 10.1371/journal.pone.0107475 10.1074/mcp.RA118.000988 10.1242/dev.01595 10.1007/s00425-020-03516-w 10.1093/pcp/pcac041 10.1126/sciadv.abo3416 10.1046/j.1432-1033.2002.03172.x 10.1016/j.mec.2022.e00207 10.1128/JB.00248-20 10.3389/fpls.2023.1220732 10.1146/annurev.arplant.50.1.473 10.1098/rstb.2023.0352 10.1104/pp.16.01230 10.1038/nchembio.1693 10.1074/jbc.M110.111856 10.1104/pp.64.5.727 10.1111/tpj.13730 10.1016/j.tplants.2020.02.005 10.1111/1365-2745.13208 10.1111/tpj.15597 10.1093/mp/ssq048 10.1039/D3NP00037K 10.1111/tpj.12775 10.1021/bi0495127 10.3389/fpls.2018.01461 10.1074/jbc.M114.591123 10.1016/j.febslet.2010.09.037 10.1111/j.1469-8137.2009.03113.x 10.1146/annurev-arplant-080620-031054 10.1038/nchembio.2414 10.1038/nchembio.485 10.1007/BF00393730 10.1111/pbi.12253 10.2307/3870046 10.1016/j.jbc.2023.102939 10.1038/s41598-020-67671-6 10.1038/ncomms9142 10.1146/annurev-arplant-042817-040226 10.1016/j.phytochem.2016.09.007 10.1021/acs.biochem.2c00465 10.1016/j.bbabio.2014.11.012 10.1038/s41467-019-08476-8 10.1111/tpj.15686 10.1042/BCJ20190523 10.1093/mp/ssp106 10.1104/pp.68.2.292 10.1038/s41467-023-42587-7 10.1042/BCJ20170549 10.1104/pp.110.157370 10.1016/j.molp.2016.09.010 10.1105/tpc.107.057455 10.1073/pnas.83.19.7231 10.1093/plphys/kiab454 10.3390/cells13110929 10.1105/tpc.104.028837 10.1093/jxb/ert398 10.1111/nph.18686 10.1038/s41589-020-0519-8 10.1093/jxb/ert250 10.1016/j.jbc.2022.101609 10.1111/nph.70325 10.1111/tpj.13195 10.1105/tpc.113.112557 10.1093/hr/uhac052 10.1146/annurev-genet-102209-163508 10.1146/annurev-arplant-042811-105439 10.1007/s11101-023-09889-6 10.1007/s11103-011-9739-3 10.1105/tpc.109.073247 |
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| References | Qian (bb0320) 2019; 10 Brilisauer (bb0240) 2019; 10 Liu (bb0370) 2025; 37 Widhalm (bb0315) 2015; 6 Gritsunov (bb0685) 2018; 95 Vogt (bb0025) 2010; 3 Oliva (bb0205) 2015; 13 Corea (bb0310) 2012; 287 Rippert, Matringe (bb0390) 2002; 269 Zhong (bb0295) 2020; 10 Orduña (bb0265) 2022; 110 Dynamic retuning of precursor supply before and after the evolution of the dual lignin pathway in Poales. Pribat (bb0355) 2010; 22 El-Azaz (bb0400) 2022; 188 Walker (bb0095) 1996; 142 Liu (bb0255) 2022; 8 Eremina (bb0575) 2015; 81 Rei Liao (bb0435) 2022; 298 Zhang (bb0635) 2015; 8 Tzin, Galili (bb0010) 2010; 3 Almeida (bb0050) 2024; 23 Wang (bb0495) 2019; 294 Manela (bb0200) 2015; 6 Westfall (bb0335) 2014; 289 Dong (bb0650) 2021; 63 Kanaris (bb0140) 2022; 109 Maeda (bb0360) 2011; 7 Zhao (bb0500) 2018; 69 Lynch (bb0505) 2020; 16 Singh, Christendat (bb0675) 2006; 45 de Oliveira (bb0165) 2019; 97 El-Azaz (bb0380) 2016; 87 Zheng (bb0515) 2013; 9 Larsen (bb0525) 1981; 68 Meinke (bb0280) 2020; 226 Chen (bb0410) 2016; 9 Yoo (bb0405) 2021; 108 Doering (bb0535) 2024; 75 Huang (bb0710) 2019; 10 Rubin (bb0460) 1979; 64 de Raad (bb0475) 2023; 299 Lynch, Dudareva (bb0075) 2020; 25 Neetu (bb0230) 2020; 202 Vanholme (bb0610) 2013; 341 El-Azaz, Maeda (bb0180) 2024; 120 Bentley (bb0030) 1990; 25 Jiao (bb0150) 2012; 415 Maeda (bb0305) 2010; 22 de Vries (bb0545) 2018; 11 Evans (bb0620) 2024; 10 Koper, K. Sharkey (bb0520) 2021; 10 Yoo (bb0350) 2013; 4 Jung (bb0385) 1986; 83 Yokoyama, Maeda (bb0670) 2025; 9 Wang (bb0285) 2023; 238 Maeda, Dudareva (bb0005) 2012; 63 Tzin (bb0185) 2012; 194 Yokoyama (bb0110) 2021; 33 Verdonk (bb0425) 2005; 17 Lea (bb0590) 2001; 20 Pagnussat (bb0275) 2005; 132 Herrmann, Weaver (bb0035) 1999; 50 Hilgers (bb0560) 2018; 9 Pascual (bb0420) 2017; 16 Guo (bb0695) 2014; 289 Prabhakar (bb0565) 2009; 583 Lopez-Nieves (bb0445) 2022; 109 Hildebrandt (bb0490) 2015; 8 Tahara (bb0715) 2020; 253 Andriotis (bb0570) 2010; 185 Coley (bb0465) 2019; 107 Tzin (bb0190) 2013; 64 Maeda, Fernie (bb0040) 2021; 72 Zhang (bb0640) 2015; 6 Gaines (bb0395) 1982; 156 Mapping multi-substrate specificity of Herrmann (bb0085) 1995; 7 Lin (bb0195) 2022; 15 Ding (bb0680) 2007; 58 Yokoyama (bb0045) 2024; 379 Bomal (bb0100) 2014; 65 Wang (bb0480) 2016; 132 Bouchnak (bb0725) 2019; 18 El-Azaz (bb0120) 2023; 14 Perez (bb0510) 2023; 12 El-Azaz (bb0415) 2020; 71 Yokoyama (bb0090) 2022; 67 Jensen (bb0660) 1986; 66 Brown (bb0595) 2010; 61 Muir (bb0700) 2011; 75 Yamada (bb0625) 2008; 20 Kroll (bb0345) 2017; 474 Wang (bb0645) 2022; 67 Boerjan (bb0015) 2003; 54 Cho (bb0375) 2007; 282 de la Torre (bb0340) 2024; 13 Graindorge (bb0365) 2010; 584 Barros (bb0450) 2016; 2 Wu (bb0550) 2025; 23 Balachandran (bb0155) 2022; 61 Lynch (bb0655) 2017; 92 Yokoyama (bb0115) 2022; 8 Muhammad (bb0430) 2023; 14 Macheroux (bb0250) 1999; 207 Choung (bb0270) 2025 aminotransferases. Bonawitz, Chapple (bb0020) 2010; 44 Lopez-Nieves (bb0440) 2018; 217 Takeda-Kimura (bb0455) 2024 Oliva (bb0210) 2021; 11 Bontpart (bb0705) 2016; 67 White (bb0055) 2004; 43 Uy (bb0260) 2023; 64 Shende (bb0070) 2024; 41 Prabhakar (bb0555) 2010; 22 Ying (bb0105) 2020; 18 Carrington (bb0690) 2018; 95 Lynch (bb0080) 2022; 9 Schmidt (bb0245) 1990; 93 Parsley (bb0585) 2006; 62 Gulko (bb0060) 2014; 9 Webby (bb0160) 2010; 285 in press Doong (bb0665) 1992; 84 Entus (bb0125) 2002; 129 Obayashi (bb0225) 2022; 63 Schenck (bb0325) 2015; 11 Rojas (bb0605) 2019; 476 Adams (bb0615) 2019; 462 Rippert (bb0300) 2009; 149 Colquhoun (bb0720) 2010; 61 Schenck (bb0330) 2017; 13 Ohtani (bb0600) 2016; 172 Huang (bb0630) 2010; 153 Wu (bb0170) 2024; 10 Yuan (bb0290) 2022; 23 El-Azaz, J. Eastmond (bb0580) 2015; 6 Nishimura (bb0135) 2015; 1847 Xu (bb0530) 2024; 242 Nishimura (bb0130) 2013; 25 Tang (bb0175) 2024; 67 Jiao (bb0220) 2020; 295 Rapp (bb0235) 2021; 12 Tohge (bb0145) 2013; 4 Hubrich (bb0065) 2021; 57 Schenck (bb0470) 2020; 4 Vanholme (bb0540) 2012; 24 Wu (10.1016/j.tibs.2025.07.008_bb0550) 2025; 23 Brilisauer (10.1016/j.tibs.2025.07.008_bb0240) 2019; 10 Eremina (10.1016/j.tibs.2025.07.008_bb0575) 2015; 81 Walker (10.1016/j.tibs.2025.07.008_bb0095) 1996; 142 Andriotis (10.1016/j.tibs.2025.07.008_bb0570) 2010; 185 Huang (10.1016/j.tibs.2025.07.008_bb0710) 2019; 10 10.1016/j.tibs.2025.07.008_bb0215 Yokoyama (10.1016/j.tibs.2025.07.008_bb0110) 2021; 33 Bouchnak (10.1016/j.tibs.2025.07.008_bb0725) 2019; 18 Yokoyama (10.1016/j.tibs.2025.07.008_bb0115) 2022; 8 Schmidt (10.1016/j.tibs.2025.07.008_bb0245) 1990; 93 Rippert (10.1016/j.tibs.2025.07.008_bb0300) 2009; 149 Tohge (10.1016/j.tibs.2025.07.008_bb0145) 2013; 4 Lynch (10.1016/j.tibs.2025.07.008_bb0505) 2020; 16 Kroll (10.1016/j.tibs.2025.07.008_bb0345) 2017; 474 Webby (10.1016/j.tibs.2025.07.008_bb0160) 2010; 285 Jiao (10.1016/j.tibs.2025.07.008_bb0220) 2020; 295 El-Azaz (10.1016/j.tibs.2025.07.008_bb0120) 2023; 14 Neetu (10.1016/j.tibs.2025.07.008_bb0230) 2020; 202 Hildebrandt (10.1016/j.tibs.2025.07.008_bb0490) 2015; 8 Boerjan (10.1016/j.tibs.2025.07.008_bb0015) 2003; 54 Widhalm (10.1016/j.tibs.2025.07.008_bb0315) 2015; 6 Oliva (10.1016/j.tibs.2025.07.008_bb0205) 2015; 13 Bomal (10.1016/j.tibs.2025.07.008_bb0100) 2014; 65 Lea (10.1016/j.tibs.2025.07.008_bb0590) 2001; 20 Colquhoun (10.1016/j.tibs.2025.07.008_bb0720) 2010; 61 Parsley (10.1016/j.tibs.2025.07.008_bb0585) 2006; 62 Ying (10.1016/j.tibs.2025.07.008_bb0105) 2020; 18 Choung (10.1016/j.tibs.2025.07.008_bb0270) 2025 Dong (10.1016/j.tibs.2025.07.008_bb0650) 2021; 63 Yokoyama (10.1016/j.tibs.2025.07.008_bb0090) 2022; 67 Tahara (10.1016/j.tibs.2025.07.008_bb0715) 2020; 253 Obayashi (10.1016/j.tibs.2025.07.008_bb0225) 2022; 63 Corea (10.1016/j.tibs.2025.07.008_bb0310) 2012; 287 Gaines (10.1016/j.tibs.2025.07.008_bb0395) 1982; 156 Gritsunov (10.1016/j.tibs.2025.07.008_bb0685) 2018; 95 Balachandran (10.1016/j.tibs.2025.07.008_bb0155) 2022; 61 Schenck (10.1016/j.tibs.2025.07.008_bb0330) 2017; 13 Ding (10.1016/j.tibs.2025.07.008_bb0680) 2007; 58 Maeda (10.1016/j.tibs.2025.07.008_bb0040) 2021; 72 Perez (10.1016/j.tibs.2025.07.008_bb0510) 2023; 12 Larsen (10.1016/j.tibs.2025.07.008_bb0525) 1981; 68 Wang (10.1016/j.tibs.2025.07.008_bb0480) 2016; 132 Tzin (10.1016/j.tibs.2025.07.008_bb0010) 2010; 3 Lopez-Nieves (10.1016/j.tibs.2025.07.008_bb0440) 2018; 217 Yokoyama (10.1016/j.tibs.2025.07.008_bb0045) 2024; 379 Macheroux (10.1016/j.tibs.2025.07.008_bb0250) 1999; 207 Lynch (10.1016/j.tibs.2025.07.008_bb0075) 2020; 25 Prabhakar (10.1016/j.tibs.2025.07.008_bb0555) 2010; 22 Vanholme (10.1016/j.tibs.2025.07.008_bb0610) 2013; 341 Nishimura (10.1016/j.tibs.2025.07.008_bb0130) 2013; 25 Maeda (10.1016/j.tibs.2025.07.008_bb0005) 2012; 63 Singh (10.1016/j.tibs.2025.07.008_bb0675) 2006; 45 Tzin (10.1016/j.tibs.2025.07.008_bb0190) 2013; 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11 Takeda-Kimura (10.1016/j.tibs.2025.07.008_bb0455) 2024 Wang (10.1016/j.tibs.2025.07.008_bb0645) 2022; 67 Doering (10.1016/j.tibs.2025.07.008_bb0535) 2024; 75 Herrmann (10.1016/j.tibs.2025.07.008_bb0085) 1995; 7 Graindorge (10.1016/j.tibs.2025.07.008_bb0365) 2010; 584 Meinke (10.1016/j.tibs.2025.07.008_bb0280) 2020; 226 Kanaris (10.1016/j.tibs.2025.07.008_bb0140) 2022; 109 El-Azaz (10.1016/j.tibs.2025.07.008_bb0380) 2016; 87 Lin (10.1016/j.tibs.2025.07.008_bb0195) 2022; 15 Wang (10.1016/j.tibs.2025.07.008_bb0285) 2023; 238 Adams (10.1016/j.tibs.2025.07.008_bb0615) 2019; 462 Rei Liao (10.1016/j.tibs.2025.07.008_bb0435) 2022; 298 Rojas (10.1016/j.tibs.2025.07.008_bb0605) 2019; 476 Guo (10.1016/j.tibs.2025.07.008_bb0695) 2014; 289 Qian (10.1016/j.tibs.2025.07.008_bb0320) 2019; 10 Bontpart (10.1016/j.tibs.2025.07.008_bb0705) 2016; 67 Barros (10.1016/j.tibs.2025.07.008_bb0450) 2016; 2 Doong (10.1016/j.tibs.2025.07.008_bb0665) 1992; 84 Yamada (10.1016/j.tibs.2025.07.008_bb0625) 2008; 20 Xu (10.1016/j.tibs.2025.07.008_bb0530) 2024; 242 Rubin (10.1016/j.tibs.2025.07.008_bb0460) 1979; 64 Vanholme (10.1016/j.tibs.2025.07.008_bb0540) 2012; 24 Pribat (10.1016/j.tibs.2025.07.008_bb0355) 2010; 22 Schenck (10.1016/j.tibs.2025.07.008_bb0470) 2020; 4 Brown (10.1016/j.tibs.2025.07.008_bb0595) 2010; 61 Uy (10.1016/j.tibs.2025.07.008_bb0260) 2023; 64 Nishimura (10.1016/j.tibs.2025.07.008_bb0135) 2015; 1847 10.1016/j.tibs.2025.07.008_bb0485 Maeda (10.1016/j.tibs.2025.07.008_bb0305) 2010; 22 de Raad (10.1016/j.tibs.2025.07.008_bb0475) 2023; 299 Oliva (10.1016/j.tibs.2025.07.008_bb0210) 2021; 11 Rapp (10.1016/j.tibs.2025.07.008_bb0235) 2021; 12 Yokoyama (10.1016/j.tibs.2025.07.008_bb0670) 2025; 9 Jensen (10.1016/j.tibs.2025.07.008_bb0660) 1986; 66 Ohtani (10.1016/j.tibs.2025.07.008_bb0600) 2016; 172 Liu (10.1016/j.tibs.2025.07.008_bb0370) 2025; 37 Bonawitz (10.1016/j.tibs.2025.07.008_bb0020) 2010; 44 Hilgers (10.1016/j.tibs.2025.07.008_bb0560) 2018; 9 Huang (10.1016/j.tibs.2025.07.008_bb0630) 2010; 153 Zhang (10.1016/j.tibs.2025.07.008_bb0640) 2015; 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| References_xml | – volume: 58 start-page: 2053 year: 2007 end-page: 2067 ident: bb0680 article-title: Functional analysis of the essential bifunctional tobacco enzyme 3-dehydroquinate dehydratase/shikimate dehydrogenase in transgenic tobacco plants publication-title: J. Exp. Bot. – volume: 12 start-page: 266 year: 2023 ident: bb0510 article-title: Occurrence, function, and biosynthesis of the natural auxin phenylacetic acid (PAA) in plants publication-title: Plants – volume: 43 start-page: 7618 year: 2004 end-page: 7627 ident: bb0055 article-title: L-aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in publication-title: Biochemistry – volume: 67 year: 2022 ident: bb0090 article-title: 3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase as the gatekeeper of plant aromatic natural product biosynthesis publication-title: Curr. Opin. Plant Biol. – volume: 142 start-page: 1973 year: 1996 end-page: 1982 ident: bb0095 article-title: Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase in publication-title: Microbiology – volume: 107 start-page: 1620 year: 2019 end-page: 1632 ident: bb0465 article-title: Macroevolutionary patterns in overexpression of tyrosine: an anti-herbivore defence in a speciose tropical tree genus, publication-title: J. Ecol. – volume: 63 start-page: 869 year: 2022 end-page: 881 ident: bb0225 article-title: ATTED-II v11: a plant gene coexpression database using a sample balancing technique by subagging of principal components publication-title: Plant Cell Physiol. – volume: 75 start-page: 2848 year: 2024 end-page: 2866 ident: bb0535 article-title: Evidence for dual targeting control of publication-title: J. Exp. Bot. – volume: 81 start-page: 895 year: 2015 end-page: 906 ident: bb0575 article-title: ENO2 activity is required for the development and reproductive success of plants, and is feedback-repressed by AtMBP-1 publication-title: Plant J. – volume: 10 start-page: 1453 year: 2024 end-page: 1463 ident: bb0620 article-title: Rubisco supplies pyruvate for the 2-C-methyl-D-erythritol-4-phosphate pathway publication-title: Nat Plants – volume: 282 start-page: 30827 year: 2007 end-page: 30835 ident: bb0375 article-title: Phenylalanine biosynthesis in publication-title: J. Biol. Chem. – volume: 6 start-page: 8142 year: 2015 ident: bb0315 article-title: Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network publication-title: Nat. Commun. – volume: 8 year: 2022 ident: bb0115 article-title: Point mutations that boost aromatic amino acid production and CO2 assimilation in plants publication-title: Sci. Adv. – volume: 20 start-page: 1316 year: 2008 end-page: 1329 ident: bb0625 article-title: Mutation of a rice gene encoding a phenylalanine biosynthetic enzyme results in accumulation of phenylalanine and tryptophan publication-title: Plant Cell – volume: 120 start-page: 2286 year: 2024 end-page: 2304 ident: bb0180 article-title: A simplified liquid chromatography-mass spectrometry methodology to probe the shikimate and aromatic amino acid biosynthetic pathways in plants publication-title: Plant J. – volume: 238 start-page: 155 year: 2023 end-page: 168 ident: bb0285 article-title: The female germ unit is essential for pollen tube funicular guidance in publication-title: New Phytol. – volume: 87 start-page: 215 year: 2016 end-page: 229 ident: bb0380 article-title: Identification of a small protein domain present in all plant lineages that confers high prephenate dehydratase activity publication-title: Plant J. – volume: 61 start-page: 2229 year: 2022 end-page: 2240 ident: bb0155 article-title: Role of half-of-sites reactivity and inter-subunit communications in DAHP synthase catalysis and regulation publication-title: Biochemistry – volume: 8 start-page: 17 year: 2015 end-page: 27 ident: bb0635 article-title: Multifaceted regulations of gateway enzyme phenylalanine ammonia-lyase in the biosynthesis of phenylpropanoids publication-title: Mol. Plant – volume: 110 start-page: 529 year: 2022 end-page: 547 ident: bb0265 article-title: Direct regulation of shikimate, early phenylpropanoid, and stilbenoid pathways by Subgroup 2 R2R3-MYBs in grapevine publication-title: Plant J. – volume: 4 start-page: 2833 year: 2013 ident: bb0350 article-title: An alternative pathway contributes to phenylalanine biosynthesis in plants via a cytosolic tyrosine:phenylpyruvate aminotransferase publication-title: Nat. Commun. – volume: 61 start-page: 145 year: 2010 end-page: 155 ident: bb0720 article-title: A petunia chorismate mutase specialized for the production of floral volatiles publication-title: Plant J. – volume: 41 start-page: 604 year: 2024 end-page: 648 ident: bb0070 article-title: The shikimate pathway: gateway to metabolic diversity publication-title: Nat. Prod. Rep. – volume: 72 start-page: 185 year: 2021 end-page: 216 ident: bb0040 article-title: Evolutionary history of plant metabolism publication-title: Annu. Rev. Plant Biol. – volume: 12 year: 2021 ident: bb0235 article-title: In vivo inhibition of the 3-dehydroquinate synthase by 7-deoxysedoheptulose depends on promiscuous uptake by sugar transporters in cyanobacteria publication-title: Front. Microbiol. – volume: 10 start-page: 545 year: 2019 ident: bb0240 article-title: Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms publication-title: Nat. Commun. – volume: 584 start-page: 4357 year: 2010 end-page: 4360 ident: bb0365 article-title: Identification of a plant gene encoding glutamate/aspartate-prephenate aminotransferase: the last homeless enzyme of aromatic amino acids biosynthesis publication-title: FEBS Lett. – volume: 10 start-page: 10846 year: 2020 ident: bb0295 article-title: Suppression of chorismate synthase, which is localized in chloroplasts and peroxisomes, results in abnormal flower development and anthocyanin reduction in petunia publication-title: Sci. Rep. – volume: 83 start-page: 7231 year: 1986 end-page: 7235 ident: bb0385 article-title: Chloroplasts of higher plants synthesize L-phenylalanine via L-arogenate publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 65 start-page: 495 year: 2014 end-page: 508 ident: bb0100 article-title: Opposite action of R2R3-MYBs from different subgroups on key genes of the shikimate and monolignol pathways in spruce publication-title: J. Exp. Bot. – volume: 194 start-page: 430 year: 2012 end-page: 439 ident: bb0185 article-title: Expression of a bacterial feedback-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway in publication-title: New Phytol. – volume: 6 start-page: 8635 year: 2015 ident: bb0640 article-title: Multi-level engineering facilitates the production of phenylpropanoid compounds in tomato publication-title: Nat. Commun. – volume: 67 start-page: 2488 year: 2024 end-page: 2498 ident: bb0175 article-title: 6-Phosphogluconate dehydrogenase 2 bridges the OPP and shikimate pathways to enhance aromatic amino acid production in plants publication-title: Sci. China Life Sci. – volume: 10 year: 2024 ident: bb0170 article-title: The cytosolic aminotransferase VAS1 coordinates aromatic amino acid biosynthesis and metabolism publication-title: Sci. Adv. – volume: 295 start-page: 6252 year: 2020 end-page: 6262 ident: bb0220 article-title: A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in publication-title: J. Biol. Chem. – volume: 299 year: 2023 ident: bb0475 article-title: Mass spectrometry imaging-based assays for aminotransferase activity reveal a broad substrate spectrum for a previously uncharacterized enzyme publication-title: J. Biol. Chem. – volume: 294 start-page: 3563 year: 2019 end-page: 3576 ident: bb0495 article-title: TAT1 and TAT2 tyrosine aminotransferases have both distinct and shared functions in tyrosine metabolism and degradation in publication-title: J. Biol. Chem. – volume: 9 start-page: 1461 year: 2018 ident: bb0560 article-title: The xylulose 5-phosphate/phosphate translocator supports triose phosphate, but not phosphoenolpyruvate transport across the inner envelope membrane of plastids in publication-title: Front. Plant Sci. – volume: 3 start-page: 2 year: 2010 end-page: 20 ident: bb0025 article-title: Phenylpropanoid biosynthesis publication-title: Mol. Plant – volume: 64 start-page: 1563 year: 2023 end-page: 1575 ident: bb0260 article-title: The carbon flow shifts from primary to secondary metabolism during xylem vessel cell differentiation in publication-title: Plant Cell Physiol. – volume: 33 start-page: 671 year: 2021 end-page: 696 ident: bb0110 article-title: The entry reaction of the plant shikimate pathway is subjected to highly complex metabolite-mediated regulation publication-title: Plant Cell – reference: aminotransferases. – reference: Mapping multi-substrate specificity of – volume: 14 year: 2023 ident: bb0430 article-title: Arogenate dehydratases: unique roles in light-directed development during the seed-to-seedling transition in publication-title: Front. Plant Sci. – volume: 6 start-page: 6659 year: 2015 ident: bb0580 article-title: Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment publication-title: Nat. Commun. – volume: 153 start-page: 1526 year: 2010 end-page: 1538 ident: bb0630 article-title: Functional analysis of the arabidopsis PAL gene family in plant growth, development, and Response to environmental stress publication-title: Plant Physiol. – volume: 54 start-page: 519 year: 2003 end-page: 546 ident: bb0015 article-title: Lignin biosynthesis publication-title: Annu. Rev. Plant Biol. – volume: 24 start-page: 3506 year: 2012 end-page: 3529 ident: bb0540 article-title: A systems biology view of responses to lignin biosynthesis perturbations in publication-title: Plant Cell – volume: 132 start-page: 603 year: 2005 end-page: 614 ident: bb0275 article-title: Genetic and molecular identification of genes required for female gametophyte development and function in publication-title: Development – volume: 8 start-page: 1233 year: 2022 end-page: 1244 ident: bb0255 article-title: Natural allelic variation confers high resistance to sweet potato weevils in sweet potato publication-title: Nat Plants – volume: 68 start-page: 292 year: 1981 end-page: 299 ident: bb0525 article-title: Amino acid synthesis in photosynthesizing spinach cells: effects of ammonia on pool sizes and rates of labeling from CO2 publication-title: Plant Physiol. – volume: 67 year: 2022 ident: bb0645 article-title: Natural variance at the interface of plant primary and specialized metabolism publication-title: Curr. Opin. Plant Biol. – volume: 109 start-page: 789 year: 2022 end-page: 803 ident: bb0140 article-title: Elevated tyrosine results in the cytosolic retention of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase in publication-title: Plant J. – volume: 25 start-page: 670 year: 2020 end-page: 681 ident: bb0075 article-title: Aromatic amino acids: a complex network ripe for future exploration publication-title: Trends Plant Sci. – volume: 37 year: 2025 ident: bb0370 article-title: Maize big embryo 6 reveals roles of plastidial and cytosolic prephenate aminotransferases in seed and plant development publication-title: Plant Cell – volume: 4 start-page: 62 year: 2013 ident: bb0145 article-title: Shikimate and phenylalanine biosynthesis in the green lineage publication-title: Front. Plant Sci. – volume: 67 start-page: 3537 year: 2016 end-page: 3550 ident: bb0705 article-title: Two shikimate dehydrogenases, VvSDH3 and VvSDH4, are involved in gallic acid biosynthesis in grapevine publication-title: J. Exp. Bot. – volume: 10 start-page: 1547 year: 2021 ident: bb0520 article-title: Pentose phosphate pathway reactions in photosynthesizing cells publication-title: Cells – volume: 9 start-page: 244 year: 2013 end-page: 246 ident: bb0515 article-title: Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1 publication-title: Nat. Chem. Biol. – volume: 57 start-page: 2441 year: 2021 end-page: 2463 ident: bb0065 article-title: Chorismate- and isochorismate converting enzymes: versatile catalysts acting on an important metabolic node publication-title: Chem. Commun. – volume: 18 start-page: 1285 year: 2019 end-page: 1306 ident: bb0725 article-title: Unraveling hidden components of the chloroplast envelope proteome: opportunities and limits of better MS sensitivity publication-title: Mol. Cell. Proteomics – volume: 10 start-page: 1268 year: 2019 ident: bb0710 article-title: Functional analysis of 3-dehydroquinate dehydratase/shikimate dehydrogenases involved in shikimate pathway in publication-title: Front. Plant Sci. – volume: 95 start-page: 823 year: 2018 end-page: 833 ident: bb0690 article-title: Evolution of a secondary metabolic pathway from primary metabolism: shikimate and quinate biosynthesis in plants publication-title: Plant J. – volume: 6 start-page: 538 year: 2015 ident: bb0200 article-title: Phenylalanine and tyrosine levels are rate-limiting factors in production of health promoting metabolites in publication-title: Front. Plant Sci. – volume: 23 start-page: 15964 year: 2022 ident: bb0290 article-title: Shikimate kinase plays important roles in anthocyanin synthesis in publication-title: Int. J. Mol. Sci. – volume: 149 start-page: 1251 year: 2009 end-page: 1260 ident: bb0300 article-title: Tyrosine and phenylalanine are synthesized within the plastids in publication-title: Plant Physiol. – volume: 20 start-page: 225 year: 2001 end-page: 241 ident: bb0590 article-title: Does phosphoenolpyruvate carboxykinase have a role in both amino acid and carbohydrate metabolism? publication-title: Amino Acids – volume: 45 start-page: 7787 year: 2006 end-page: 7796 ident: bb0675 article-title: Structure of arabidopsis dehydroquinate dehydratase-shikimate dehydrogenase and implications for metabolic channeling in the shikimate pathway publication-title: Biochemistry – volume: 92 start-page: 939 year: 2017 end-page: 950 ident: bb0655 article-title: Multifaceted plant responses to circumvent Phe hyperaccumulation by downregulation of flux through the shikimate pathway and by vacuolar Phe sequestration publication-title: Plant J. – volume: 64 start-page: 4441 year: 2013 end-page: 4452 ident: bb0190 article-title: Tomato fruits expressing a bacterial feedback-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway possess enhanced levels of multiple specialized metabolites and upgraded aroma publication-title: J. Exp. Bot. – volume: 63 start-page: 73 year: 2012 end-page: 105 ident: bb0005 article-title: The shikimate pathway and aromatic amino acid biosynthesis in plants publication-title: Annu. Rev. Plant Biol. – volume: 64 start-page: 727 year: 1979 end-page: 734 ident: bb0460 article-title: Enzymology of L-tyrosine biosynthesis in mung bean ( publication-title: Plant Physiol. – volume: 7 start-page: 907 year: 1995 end-page: 919 ident: bb0085 article-title: The shikimate pathway: early steps in the biosynthesis of aromatic compounds publication-title: Plant Cell – volume: 66 start-page: 164 year: 1986 end-page: 168 ident: bb0660 article-title: The shikimate/arogenate pathway: link between carbohydrate metabolism and secondary metabolism publication-title: Physiol. Plant. – reference: El-Azaz, J. – volume: 129 start-page: 1866 year: 2002 end-page: 1871 ident: bb0125 article-title: Redox regulation of arabidopsis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase publication-title: Plant Physiol. – volume: 415 start-page: 716 year: 2012 end-page: 726 ident: bb0150 article-title: Dynamic cross-talk among remote binding sites: the molecular basis for unusual synergistic allostery publication-title: J. Mol. Biol. – volume: 476 start-page: 2939 year: 2019 end-page: 2952 ident: bb0605 article-title: Biochemical characterization of phosphoenolpyruvate carboxykinases from publication-title: Biochem. J. – volume: 583 start-page: 983 year: 2009 end-page: 991 ident: bb0565 article-title: Molecular and functional characterization of the plastid-localized phosphoenolpyruvate enolase (ENO1) from publication-title: FEBS Lett. – volume: 341 start-page: 1103 year: 2013 end-page: 1106 ident: bb0610 article-title: Caffeoyl shikimate esterase (CSE) is an enzyme in the lignin biosynthetic pathway in publication-title: Science – year: 2024 ident: bb0455 article-title: Genomes of Poaceae sisters reveal key metabolic innovations preceding the emergence of grasses publication-title: BioRxiv – volume: 11 start-page: 52 year: 2015 end-page: 57 ident: bb0325 article-title: Non-plastidic, tyrosine-insensitive prephenate dehydrogenases from legumes publication-title: Nat. Chem. Biol. – volume: 285 start-page: 30567 year: 2010 end-page: 30576 ident: bb0160 article-title: Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in publication-title: J. Biol. Chem. – volume: 22 start-page: 2594 year: 2010 end-page: 2617 ident: bb0555 article-title: Phosphoenolpyruvate provision to plastids is essential for gametophyte and sporophyte development in publication-title: Plant Cell – volume: 217 start-page: 896 year: 2018 end-page: 908 ident: bb0440 article-title: Relaxation of tyrosine pathway regulation underlies the evolution of betalain pigmentation in Caryophyllales publication-title: New Phytol. – volume: 298 year: 2022 ident: bb0435 article-title: Proteomics, phylogenetics, and coexpression analyses indicate novel interactions in the plastid CLP chaperone-protease system publication-title: J. Biol. Chem. – reference: Koper, K. – volume: 13 start-page: 125 year: 2015 end-page: 136 ident: bb0205 article-title: Enhanced formation of aromatic amino acids increases fragrance without affecting flower longevity or pigmentation in publication-title: Plant Biotechnol. J. – volume: 9 start-page: 1609 year: 2016 end-page: 1619 ident: bb0410 article-title: Arogenate dehydratase isoforms differentially regulate anthocyanin biosynthesis in publication-title: Mol. Plant – volume: 4 year: 2020 ident: bb0470 article-title: Role of cytosolic, tyrosine-insensitive prephenate dehydrogenase in publication-title: Plant Direct. – volume: 25 start-page: 2276 year: 2013 end-page: 2301 ident: bb0130 article-title: ClpS1 is a conserved substrate selector for the chloroplast Clp protease system in publication-title: Plant Cell – volume: 15 year: 2022 ident: bb0195 article-title: Engineering sorghum for higher 4-hydroxybenzoic acid content publication-title: Metab. Eng. Commun. – volume: 22 start-page: 3410 year: 2010 end-page: 3422 ident: bb0355 article-title: Nonflowering plants possess a unique folate-dependent phenylalanine hydroxylase that is localized in chloroplasts publication-title: Plant Cell – volume: 71 start-page: 3080 year: 2020 end-page: 30893 ident: bb0415 article-title: Transcriptional analysis of arogenate dehydratase genes identifies a link between phenylalanine biosynthesis and lignin biosynthesis publication-title: J. Exp. Bot. – volume: 50 start-page: 473 year: 1999 end-page: 503 ident: bb0035 article-title: The shikimate pathway publication-title: Annu. Rev. Plant Physiol. Plant Mol. Biol. – volume: 23 start-page: 421 year: 2024 end-page: 457 ident: bb0050 article-title: Revisiting the shikimate pathway and highlighting their enzyme inhibitors publication-title: Phytochem. Rev. – volume: 287 start-page: 11446 year: 2012 end-page: 11459 ident: bb0310 article-title: Arogenate dehydratase isoenzymes profoundly and differentially modulate carbon flux into lignins publication-title: J. Biol. Chem. – volume: 61 start-page: 122 year: 2010 end-page: 133 ident: bb0595 article-title: C acid decarboxylases required for C photosynthesis are active in the mid-vein of the C species publication-title: Plant J. – volume: 84 start-page: 351 year: 1992 end-page: 360 ident: bb0665 article-title: The cytosolic isoenzyme of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase in publication-title: Physiol. Plant. – volume: 1847 start-page: 915 year: 2015 end-page: 930 ident: bb0135 article-title: Organization, function and substrates of the essential Clp protease system in plastids publication-title: Biochim. Biophys. Acta – volume: 202 year: 2020 ident: bb0230 article-title: Structural and biochemical analyses reveal that chlorogenic acid inhibits the shikimate pathway publication-title: J. Bacteriol. – volume: 13 start-page: 1029 year: 2017 end-page: 1035 ident: bb0330 article-title: Molecular basis of the evolution of alternative tyrosine biosynthetic routes in plants publication-title: Nat. Chem. Biol. – volume: 7 start-page: 19 year: 2011 end-page: 21 ident: bb0360 article-title: Prephenate aminotransferase directs plant phenylalanine biosynthesis via arogenate publication-title: Nat. Chem. Biol. – volume: 23 start-page: 1751 year: 2025 end-page: 1767 ident: bb0550 article-title: OsLC1, a transaldolase, regulates cell patterning and leaf morphology through modulation of secondary metabolism publication-title: Plant Biotechnol. J. – volume: 22 start-page: 832 year: 2010 end-page: 849 ident: bb0305 article-title: RNAi suppression of arogenate dehydratase 1 reveals that phenylalanine is synthesized predominantly via the arogenate pathway in petunia petals publication-title: Plant Cell – volume: 11 year: 2021 ident: bb0210 article-title: Enhanced production of aromatic amino acids in tobacco plants leads to increased phenylpropanoid metabolites and tolerance to stresses publication-title: Front. Plant Sci. – volume: 25 start-page: 307 year: 1990 end-page: 384 ident: bb0030 article-title: The shikimate pathway--a metabolic tree with many branches publication-title: Crit. Rev. Biochem. Mol. Biol. – volume: 108 start-page: 737 year: 2021 end-page: 751 ident: bb0405 article-title: Overexpression of arogenate dehydratase reveals an upstream point of metabolic control in phenylalanine biosynthesis publication-title: Plant J. – volume: 269 start-page: 4753 year: 2002 end-page: 4761 ident: bb0390 article-title: Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of publication-title: Eur. J. Biochem. – volume: 132 start-page: 16 year: 2016 end-page: 25 ident: bb0480 article-title: Biochemical properties and subcellular localization of tyrosine aminotransferases in publication-title: Phytochemistry – volume: 242 start-page: 2453 year: 2024 end-page: 2463 ident: bb0530 article-title: The oxidative pentose phosphate pathway in photosynthesis: a tale of two shunts publication-title: New Phytol. – volume: 474 start-page: 3705 year: 2017 end-page: 3717 ident: bb0345 article-title: Evolution of allosteric regulation in chorismate mutases from early plants publication-title: Biochem. J. – reference: (in press) – volume: 188 start-page: 134 year: 2022 end-page: 150 ident: bb0400 article-title: Deregulation of phenylalanine biosynthesis evolved with the emergence of vascular plants publication-title: Plant Physiol. – volume: 63 start-page: 180 year: 2021 end-page: 209 ident: bb0650 article-title: Contribution of phenylpropanoid metabolism to plant development and plant-environment interactions publication-title: J. Integr. Plant Biol. – volume: 3 start-page: 956 year: 2010 end-page: 972 ident: bb0010 article-title: New insights into the shikimate and aromatic amino acids biosynthesis pathways in plants publication-title: Mol. Plant – volume: 379 year: 2024 ident: bb0045 article-title: Evolution of aromatic amino acid metabolism in plants: a key driving force behind plant chemical diversity in aromatic natural products publication-title: Philos. Trans. R. Soc. B, Biol. Sci. – reference: Dynamic retuning of precursor supply before and after the evolution of the dual lignin pathway in Poales. – volume: 462 start-page: 158 year: 2019 end-page: 170 ident: bb0615 article-title: The regulatory role of shikimate in plant phenylalanine metabolism publication-title: J. Theor. Biol. – volume: 9 year: 2014 ident: bb0060 article-title: How do haloarchaea synthesize aromatic amino acids? publication-title: PLoS One – volume: 95 start-page: 812 year: 2018 end-page: 822 ident: bb0685 article-title: Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases publication-title: Plant J. – volume: 185 start-page: 649 year: 2010 end-page: 662 ident: bb0570 article-title: Plastidial glycolysis in developing publication-title: New Phytol. – year: 2025 ident: bb0270 article-title: MYC2 and MYC3 orchestrate pith lignification to defend Nicotiana attenuata stems against a stem-boring weevil publication-title: New Phytol. – volume: 17 start-page: 1612 year: 2005 end-page: 1624 ident: bb0425 article-title: ODORANT1 regulates fragrance biosynthesis in petunia flowers publication-title: Plant Cell – volume: 62 start-page: 339 year: 2006 end-page: 349 ident: bb0585 article-title: The publication-title: Plant Mol. Biol. – volume: 172 start-page: 1612 year: 2016 end-page: 1624 ident: bb0600 article-title: Primary metabolism during biosynthesis of secondary wall polymers of protoxylem vessel elements publication-title: Plant Physiol. – volume: 289 start-page: 23846 year: 2014 end-page: 23858 ident: bb0695 article-title: Molecular characterization of quinate and shikimate metabolism in publication-title: J. Biol. Chem. – volume: 69 start-page: 417 year: 2018 end-page: 435 ident: bb0500 article-title: Essential roles of local auxin biosynthesis in plant development and in adaptation to environmental changes publication-title: Annu. Rev. Plant Biol. – volume: 9 year: 2025 ident: bb0670 article-title: Arabidopsis 3-deoxy-d-arabino-heptulosonate 7-phosphate (DAHP) synthases of the shikimate pathway display both manganese- and cobalt-dependent activities publication-title: Plant Direct. – volume: 16 start-page: 850 year: 2020 end-page: 856 ident: bb0505 article-title: Modulation of auxin formation by the cytosolic phenylalanine biosynthetic pathway publication-title: Nat. Chem. Biol. – volume: 156 start-page: 233 year: 1982 end-page: 240 ident: bb0395 article-title: L-tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of publication-title: Planta – volume: 14 start-page: 7242 year: 2023 ident: bb0120 article-title: Coordinated regulation of the entry and exit steps of aromatic amino acid biosynthesis supports the dual lignin pathway in grasses publication-title: Nat. Commun. – volume: 226 start-page: 306 year: 2020 end-page: 325 ident: bb0280 article-title: Genome-wide identification of EMBRYO-DEFECTIVE (EMB) genes required for growth and development in publication-title: New Phytol. – volume: 75 start-page: 555 year: 2011 end-page: 565 ident: bb0700 article-title: Mechanism of gallic acid biosynthesis in bacteria ( publication-title: Plant Mol. Biol. – volume: 44 start-page: 337 year: 2010 end-page: 363 ident: bb0020 article-title: The genetics of lignin biosynthesis: connecting genotype to phenotype publication-title: Annu. Rev. Genet. – volume: 207 start-page: 325 year: 1999 end-page: 334 ident: bb0250 article-title: A unique reaction in a common pathway: mechanism and function of chorismate synthase in the shikimate pathway publication-title: Planta – volume: 10 start-page: 15 year: 2019 ident: bb0320 article-title: Completion of the cytosolic post-chorismate phenylalanine biosynthetic pathway in plants publication-title: Nat. Commun. – volume: 2 start-page: 16050 year: 2016 ident: bb0450 article-title: Role of bifunctional ammonia-lyase in grass cell wall biosynthesis publication-title: Nat Plants – volume: 97 start-page: 901 year: 2019 end-page: 922 ident: bb0165 article-title: Imbalance of tyrosine by modulating TyrA arogenate dehydrogenases impacts growth and development of publication-title: Plant J. – volume: 109 start-page: 844 year: 2022 end-page: 855 ident: bb0445 article-title: Two independently evolved natural mutations additively deregulate TyrA enzymes and boost tyrosine production in publication-title: Plant J. – volume: 13 start-page: 929 year: 2024 ident: bb0340 article-title: Properties and functional analysis of two chorismate mutases from maritime pine publication-title: Cells – volume: 289 start-page: 28619 year: 2014 end-page: 28628 ident: bb0335 article-title: Structural evolution of differential amino acid effector regulation in plant chorismate mutases publication-title: J. Biol. Chem. – volume: 253 start-page: 3 year: 2020 ident: bb0715 article-title: Dehydroquinate dehydratase/shikimate dehydrogenases involved in gallate biosynthesis of the aluminum-tolerant tree species publication-title: Planta – volume: 9 year: 2022 ident: bb0080 article-title: Revisiting the dual pathway hypothesis of Chorismate production in plants publication-title: Hortic. Res. – volume: 8 start-page: 1563 year: 2015 end-page: 1579 ident: bb0490 article-title: Amino acid catabolism in plants publication-title: Mol. Plant – volume: 16 start-page: 1094 year: 2017 end-page: 1104 ident: bb0420 article-title: PpNAC1, a main regulator of phenylalanine biosynthesis and utilization in maritime pine publication-title: Plant Biotechnol. J. – volume: 18 start-page: 354 year: 2020 end-page: 363 ident: bb0105 article-title: Trichome regulator SlMIXTA-like directly manipulates primary metabolism in tomato fruit publication-title: Plant Biotechnol. J. – volume: 11 start-page: 257 year: 2018 ident: bb0545 article-title: Stacking of a low-lignin trait with an increased guaiacyl and 5-hydroxyguaiacyl unit trait leads to additive and synergistic effects on saccharification efficiency in publication-title: Biotechnol. Biofuels – volume: 93 start-page: 758 year: 1990 end-page: 766 ident: bb0245 article-title: Shikimate kinase from spinach chloroplasts : purification, characterization, and regulatory function in aromatic amino acid biosynthesis publication-title: Plant Physiol. – volume: 142 start-page: 1973 year: 1996 ident: 10.1016/j.tibs.2025.07.008_bb0095 article-title: Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase in Streptomyces coelicolor A3(2), Streptomyces rimosus and Neurospora crassa publication-title: Microbiology doi: 10.1099/13500872-142-8-1973 – volume: 45 start-page: 7787 year: 2006 ident: 10.1016/j.tibs.2025.07.008_bb0675 article-title: Structure of arabidopsis dehydroquinate dehydratase-shikimate dehydrogenase and implications for metabolic channeling in the shikimate pathway publication-title: Biochemistry doi: 10.1021/bi060366+ – volume: 62 start-page: 339 year: 2006 ident: 10.1016/j.tibs.2025.07.008_bb0585 article-title: The Arabidopsis PPDK gene is transcribed from two promoters to produce differentially expressed transcripts responsible for cytosolic and plastidic proteins publication-title: Plant Mol. Biol. doi: 10.1007/s11103-006-9023-0 – volume: 64 start-page: 1563 year: 2023 ident: 10.1016/j.tibs.2025.07.008_bb0260 article-title: The carbon flow shifts from primary to secondary metabolism during xylem vessel cell differentiation in Arabidopsis thaliana publication-title: Plant Cell Physiol. doi: 10.1093/pcp/pcad130 – volume: 8 start-page: 17 year: 2015 ident: 10.1016/j.tibs.2025.07.008_bb0635 article-title: Multifaceted regulations of gateway enzyme phenylalanine ammonia-lyase in the biosynthesis of phenylpropanoids publication-title: Mol. Plant doi: 10.1016/j.molp.2014.11.001 – volume: 294 start-page: 3563 year: 2019 ident: 10.1016/j.tibs.2025.07.008_bb0495 article-title: TAT1 and TAT2 tyrosine aminotransferases have both distinct and shared functions in tyrosine metabolism and degradation in Arabidopsis thaliana publication-title: J. Biol. Chem. doi: 10.1074/jbc.RA118.006539 – volume: 61 start-page: 145 year: 2010 ident: 10.1016/j.tibs.2025.07.008_bb0720 article-title: A petunia chorismate mutase specialized for the production of floral volatiles publication-title: Plant J. doi: 10.1111/j.1365-313X.2009.04042.x – volume: 242 start-page: 2453 year: 2024 ident: 10.1016/j.tibs.2025.07.008_bb0530 article-title: The oxidative pentose phosphate pathway in photosynthesis: a tale of two shunts publication-title: New Phytol. doi: 10.1111/nph.19730 – volume: 23 start-page: 1751 year: 2025 ident: 10.1016/j.tibs.2025.07.008_bb0550 article-title: OsLC1, a transaldolase, regulates cell patterning and leaf morphology through modulation of secondary metabolism publication-title: Plant Biotechnol. J. doi: 10.1111/pbi.70004 – volume: 67 start-page: 3537 year: 2016 ident: 10.1016/j.tibs.2025.07.008_bb0705 article-title: Two shikimate dehydrogenases, VvSDH3 and VvSDH4, are involved in gallic acid biosynthesis in grapevine publication-title: J. Exp. Bot. doi: 10.1093/jxb/erw184 – volume: 97 start-page: 901 year: 2019 ident: 10.1016/j.tibs.2025.07.008_bb0165 article-title: Imbalance of tyrosine by modulating TyrA arogenate dehydrogenases impacts growth and development of Arabidopsis thaliana publication-title: Plant J. doi: 10.1111/tpj.14169 – volume: 295 start-page: 6252 year: 2020 ident: 10.1016/j.tibs.2025.07.008_bb0220 article-title: A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis publication-title: J. Biol. Chem. doi: 10.1074/jbc.RA120.012605 – volume: 67 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0645 article-title: Natural variance at the interface of plant primary and specialized metabolism publication-title: Curr. Opin. Plant Biol. doi: 10.1016/j.pbi.2022.102201 – volume: 93 start-page: 758 year: 1990 ident: 10.1016/j.tibs.2025.07.008_bb0245 article-title: Shikimate kinase from spinach chloroplasts : purification, characterization, and regulatory function in aromatic amino acid biosynthesis publication-title: Plant Physiol. doi: 10.1104/pp.93.2.758 – volume: 217 start-page: 896 year: 2018 ident: 10.1016/j.tibs.2025.07.008_bb0440 article-title: Relaxation of tyrosine pathway regulation underlies the evolution of betalain pigmentation in Caryophyllales publication-title: New Phytol. doi: 10.1111/nph.14822 – volume: 12 year: 2021 ident: 10.1016/j.tibs.2025.07.008_bb0235 article-title: In vivo inhibition of the 3-dehydroquinate synthase by 7-deoxysedoheptulose depends on promiscuous uptake by sugar transporters in cyanobacteria publication-title: Front. Microbiol. doi: 10.3389/fmicb.2021.692986 – volume: 66 start-page: 164 year: 1986 ident: 10.1016/j.tibs.2025.07.008_bb0660 article-title: The shikimate/arogenate pathway: link between carbohydrate metabolism and secondary metabolism publication-title: Physiol. Plant. doi: 10.1111/j.1399-3054.1986.tb01251.x – volume: 57 start-page: 2441 year: 2021 ident: 10.1016/j.tibs.2025.07.008_bb0065 article-title: Chorismate- and isochorismate converting enzymes: versatile catalysts acting on an important metabolic node publication-title: Chem. Commun. doi: 10.1039/D0CC08078K – volume: 22 start-page: 2594 year: 2010 ident: 10.1016/j.tibs.2025.07.008_bb0555 article-title: Phosphoenolpyruvate provision to plastids is essential for gametophyte and sporophyte development in Arabidopsis thaliana publication-title: Plant Cell doi: 10.1105/tpc.109.073171 – volume: 108 start-page: 737 year: 2021 ident: 10.1016/j.tibs.2025.07.008_bb0405 article-title: Overexpression of arogenate dehydratase reveals an upstream point of metabolic control in phenylalanine biosynthesis publication-title: Plant J. doi: 10.1111/tpj.15467 – volume: 341 start-page: 1103 year: 2013 ident: 10.1016/j.tibs.2025.07.008_bb0610 article-title: Caffeoyl shikimate esterase (CSE) is an enzyme in the lignin biosynthetic pathway in Arabidopsis publication-title: Science doi: 10.1126/science.1241602 – ident: 10.1016/j.tibs.2025.07.008_bb0215 – volume: 63 start-page: 180 year: 2021 ident: 10.1016/j.tibs.2025.07.008_bb0650 article-title: Contribution of phenylpropanoid metabolism to plant development and plant-environment interactions publication-title: J. Integr. Plant Biol. doi: 10.1111/jipb.13054 – volume: 84 start-page: 351 year: 1992 ident: 10.1016/j.tibs.2025.07.008_bb0665 article-title: The cytosolic isoenzyme of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase in Spinacia oleracea and other higher plants: extreme substrate ambiguity and other properties publication-title: Physiol. Plant. doi: 10.1111/j.1399-3054.1992.tb04675.x – volume: 415 start-page: 716 year: 2012 ident: 10.1016/j.tibs.2025.07.008_bb0150 article-title: Dynamic cross-talk among remote binding sites: the molecular basis for unusual synergistic allostery publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2011.11.037 – volume: 194 start-page: 430 year: 2012 ident: 10.1016/j.tibs.2025.07.008_bb0185 article-title: Expression of a bacterial feedback-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway in Arabidopsis elucidates potential metabolic bottlenecks between primary and secondary metabolism publication-title: New Phytol. doi: 10.1111/j.1469-8137.2012.04052.x – volume: 10 start-page: 1268 year: 2019 ident: 10.1016/j.tibs.2025.07.008_bb0710 article-title: Functional analysis of 3-dehydroquinate dehydratase/shikimate dehydrogenases involved in shikimate pathway in Camellia sinensis publication-title: Front. Plant Sci. doi: 10.3389/fpls.2019.01268 – volume: 4 start-page: 62 year: 2013 ident: 10.1016/j.tibs.2025.07.008_bb0145 article-title: Shikimate and phenylalanine biosynthesis in the green lineage publication-title: Front. Plant Sci. doi: 10.3389/fpls.2013.00062 – ident: 10.1016/j.tibs.2025.07.008_bb0485 – volume: 25 start-page: 307 year: 1990 ident: 10.1016/j.tibs.2025.07.008_bb0030 article-title: The shikimate pathway--a metabolic tree with many branches publication-title: Crit. Rev. Biochem. Mol. Biol. doi: 10.3109/10409239009090615 – volume: 226 start-page: 306 year: 2020 ident: 10.1016/j.tibs.2025.07.008_bb0280 article-title: Genome-wide identification of EMBRYO-DEFECTIVE (EMB) genes required for growth and development in Arabidopsis publication-title: New Phytol. doi: 10.1111/nph.16071 – volume: 58 start-page: 2053 year: 2007 ident: 10.1016/j.tibs.2025.07.008_bb0680 article-title: Functional analysis of the essential bifunctional tobacco enzyme 3-dehydroquinate dehydratase/shikimate dehydrogenase in transgenic tobacco plants publication-title: J. Exp. Bot. doi: 10.1093/jxb/erm059 – volume: 109 start-page: 789 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0140 article-title: Elevated tyrosine results in the cytosolic retention of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase in Arabidopsis thaliana publication-title: Plant J. doi: 10.1111/tpj.15590 – volume: 282 start-page: 30827 year: 2007 ident: 10.1016/j.tibs.2025.07.008_bb0375 article-title: Phenylalanine biosynthesis in Arabidopsis thaliana. Identification and characterization of arogenate dehydratases publication-title: J. Biol. Chem. doi: 10.1074/jbc.M702662200 – volume: 67 start-page: 2488 year: 2024 ident: 10.1016/j.tibs.2025.07.008_bb0175 article-title: 6-Phosphogluconate dehydrogenase 2 bridges the OPP and shikimate pathways to enhance aromatic amino acid production in plants publication-title: Sci. China Life Sci. doi: 10.1007/s11427-024-2567-4 – volume: 120 start-page: 2286 year: 2024 ident: 10.1016/j.tibs.2025.07.008_bb0180 article-title: A simplified liquid chromatography-mass spectrometry methodology to probe the shikimate and aromatic amino acid biosynthetic pathways in plants publication-title: Plant J. doi: 10.1111/tpj.17105 – volume: 6 start-page: 538 year: 2015 ident: 10.1016/j.tibs.2025.07.008_bb0200 article-title: Phenylalanine and tyrosine levels are rate-limiting factors in production of health promoting metabolites in Vitis vinifera cv. Gamay Red cell suspension publication-title: Front. Plant Sci. doi: 10.3389/fpls.2015.00538 – volume: 18 start-page: 354 year: 2020 ident: 10.1016/j.tibs.2025.07.008_bb0105 article-title: Trichome regulator SlMIXTA-like directly manipulates primary metabolism in tomato fruit publication-title: Plant Biotechnol. J. doi: 10.1111/pbi.13202 – volume: 24 start-page: 3506 year: 2012 ident: 10.1016/j.tibs.2025.07.008_bb0540 article-title: A systems biology view of responses to lignin biosynthesis perturbations in Arabidopsis publication-title: Plant Cell doi: 10.1105/tpc.112.102574 – volume: 6 start-page: 6659 year: 2015 ident: 10.1016/j.tibs.2025.07.008_bb0580 article-title: Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment publication-title: Nat. Commun. doi: 10.1038/ncomms7659 – year: 2024 ident: 10.1016/j.tibs.2025.07.008_bb0455 article-title: Genomes of Poaceae sisters reveal key metabolic innovations preceding the emergence of grasses publication-title: BioRxiv – volume: 207 start-page: 325 year: 1999 ident: 10.1016/j.tibs.2025.07.008_bb0250 article-title: A unique reaction in a common pathway: mechanism and function of chorismate synthase in the shikimate pathway publication-title: Planta doi: 10.1007/s004250050489 – volume: 9 start-page: 244 year: 2013 ident: 10.1016/j.tibs.2025.07.008_bb0515 article-title: Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1 publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.1178 – volume: 75 start-page: 2848 year: 2024 ident: 10.1016/j.tibs.2025.07.008_bb0535 article-title: Evidence for dual targeting control of Arabidopsis 6-phosphogluconate dehydrogenase isoforms by N-terminal phosphorylation publication-title: J. Exp. Bot. doi: 10.1093/jxb/erae077 – volume: 20 start-page: 225 year: 2001 ident: 10.1016/j.tibs.2025.07.008_bb0590 article-title: Does phosphoenolpyruvate carboxykinase have a role in both amino acid and carbohydrate metabolism? publication-title: Amino Acids doi: 10.1007/s007260170041 – volume: 61 start-page: 122 year: 2010 ident: 10.1016/j.tibs.2025.07.008_bb0595 article-title: C acid decarboxylases required for C photosynthesis are active in the mid-vein of the C species Arabidopsis thaliana, and are important in sugar and amino acid metabolism publication-title: Plant J. doi: 10.1111/j.1365-313X.2009.04040.x – volume: 10 start-page: 15 year: 2019 ident: 10.1016/j.tibs.2025.07.008_bb0320 article-title: Completion of the cytosolic post-chorismate phenylalanine biosynthetic pathway in plants publication-title: Nat. Commun. doi: 10.1038/s41467-018-07969-2 – volume: 8 start-page: 1233 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0255 article-title: Natural allelic variation confers high resistance to sweet potato weevils in sweet potato publication-title: Nat Plants doi: 10.1038/s41477-022-01272-1 – volume: 129 start-page: 1866 year: 2002 ident: 10.1016/j.tibs.2025.07.008_bb0125 article-title: Redox regulation of arabidopsis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase publication-title: Plant Physiol. doi: 10.1104/pp.002626 – volume: 11 year: 2021 ident: 10.1016/j.tibs.2025.07.008_bb0210 article-title: Enhanced production of aromatic amino acids in tobacco plants leads to increased phenylpropanoid metabolites and tolerance to stresses publication-title: Front. Plant Sci. doi: 10.3389/fpls.2020.604349 – volume: 95 start-page: 812 year: 2018 ident: 10.1016/j.tibs.2025.07.008_bb0685 article-title: Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases publication-title: Plant J. doi: 10.1111/tpj.13989 – volume: 16 start-page: 1094 year: 2017 ident: 10.1016/j.tibs.2025.07.008_bb0420 article-title: PpNAC1, a main regulator of phenylalanine biosynthesis and utilization in maritime pine publication-title: Plant Biotechnol. J. doi: 10.1111/pbi.12854 – volume: 9 year: 2025 ident: 10.1016/j.tibs.2025.07.008_bb0670 article-title: Arabidopsis 3-deoxy-d-arabino-heptulosonate 7-phosphate (DAHP) synthases of the shikimate pathway display both manganese- and cobalt-dependent activities publication-title: Plant Direct. doi: 10.1002/pld3.70037 – volume: 289 start-page: 23846 year: 2014 ident: 10.1016/j.tibs.2025.07.008_bb0695 article-title: Molecular characterization of quinate and shikimate metabolism in Populus trichocarpa publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.558536 – volume: 23 start-page: 15964 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0290 article-title: Shikimate kinase plays important roles in anthocyanin synthesis in Petunia publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms232415964 – volume: 33 start-page: 671 year: 2021 ident: 10.1016/j.tibs.2025.07.008_bb0110 article-title: The entry reaction of the plant shikimate pathway is subjected to highly complex metabolite-mediated regulation publication-title: Plant Cell doi: 10.1093/plcell/koaa042 – volume: 10 start-page: 1453 year: 2024 ident: 10.1016/j.tibs.2025.07.008_bb0620 article-title: Rubisco supplies pyruvate for the 2-C-methyl-D-erythritol-4-phosphate pathway publication-title: Nat Plants doi: 10.1038/s41477-024-01791-z – volume: 95 start-page: 823 year: 2018 ident: 10.1016/j.tibs.2025.07.008_bb0690 article-title: Evolution of a secondary metabolic pathway from primary metabolism: shikimate and quinate biosynthesis in plants publication-title: Plant J. doi: 10.1111/tpj.13990 – volume: 4 start-page: 2833 year: 2013 ident: 10.1016/j.tibs.2025.07.008_bb0350 article-title: An alternative pathway contributes to phenylalanine biosynthesis in plants via a cytosolic tyrosine:phenylpyruvate aminotransferase publication-title: Nat. Commun. doi: 10.1038/ncomms3833 – volume: 8 start-page: 1563 year: 2015 ident: 10.1016/j.tibs.2025.07.008_bb0490 article-title: Amino acid catabolism in plants publication-title: Mol. Plant doi: 10.1016/j.molp.2015.09.005 – volume: 37 year: 2025 ident: 10.1016/j.tibs.2025.07.008_bb0370 article-title: Maize big embryo 6 reveals roles of plastidial and cytosolic prephenate aminotransferases in seed and plant development publication-title: Plant Cell doi: 10.1093/plcell/koaf067 – volume: 583 start-page: 983 year: 2009 ident: 10.1016/j.tibs.2025.07.008_bb0565 article-title: Molecular and functional characterization of the plastid-localized phosphoenolpyruvate enolase (ENO1) from Arabidopsis thaliana publication-title: FEBS Lett. doi: 10.1016/j.febslet.2009.02.017 – volume: 54 start-page: 519 year: 2003 ident: 10.1016/j.tibs.2025.07.008_bb0015 article-title: Lignin biosynthesis publication-title: Annu. Rev. Plant Biol. doi: 10.1146/annurev.arplant.54.031902.134938 – volume: 2 start-page: 16050 year: 2016 ident: 10.1016/j.tibs.2025.07.008_bb0450 article-title: Role of bifunctional ammonia-lyase in grass cell wall biosynthesis publication-title: Nat Plants doi: 10.1038/nplants.2016.50 – volume: 71 start-page: 3080 year: 2020 ident: 10.1016/j.tibs.2025.07.008_bb0415 article-title: Transcriptional analysis of arogenate dehydratase genes identifies a link between phenylalanine biosynthesis and lignin biosynthesis publication-title: J. Exp. Bot. doi: 10.1093/jxb/eraa099 – volume: 6 start-page: 8635 year: 2015 ident: 10.1016/j.tibs.2025.07.008_bb0640 article-title: Multi-level engineering facilitates the production of phenylpropanoid compounds in tomato publication-title: Nat. Commun. doi: 10.1038/ncomms9635 – volume: 11 start-page: 257 year: 2018 ident: 10.1016/j.tibs.2025.07.008_bb0545 article-title: Stacking of a low-lignin trait with an increased guaiacyl and 5-hydroxyguaiacyl unit trait leads to additive and synergistic effects on saccharification efficiency in Arabidopsis thaliana publication-title: Biotechnol. Biofuels doi: 10.1186/s13068-018-1257-y – volume: 287 start-page: 11446 year: 2012 ident: 10.1016/j.tibs.2025.07.008_bb0310 article-title: Arogenate dehydratase isoenzymes profoundly and differentially modulate carbon flux into lignins publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.322164 – volume: 22 start-page: 3410 year: 2010 ident: 10.1016/j.tibs.2025.07.008_bb0355 article-title: Nonflowering plants possess a unique folate-dependent phenylalanine hydroxylase that is localized in chloroplasts publication-title: Plant Cell doi: 10.1105/tpc.110.078824 – volume: 149 start-page: 1251 year: 2009 ident: 10.1016/j.tibs.2025.07.008_bb0300 article-title: Tyrosine and phenylalanine are synthesized within the plastids in Arabidopsis publication-title: Plant Physiol. doi: 10.1104/pp.108.130070 – volume: 462 start-page: 158 year: 2019 ident: 10.1016/j.tibs.2025.07.008_bb0615 article-title: The regulatory role of shikimate in plant phenylalanine metabolism publication-title: J. Theor. Biol. doi: 10.1016/j.jtbi.2018.11.005 – volume: 12 start-page: 266 year: 2023 ident: 10.1016/j.tibs.2025.07.008_bb0510 article-title: Occurrence, function, and biosynthesis of the natural auxin phenylacetic acid (PAA) in plants publication-title: Plants doi: 10.3390/plants12020266 – volume: 10 start-page: 1547 year: 2021 ident: 10.1016/j.tibs.2025.07.008_bb0520 article-title: Pentose phosphate pathway reactions in photosynthesizing cells publication-title: Cells doi: 10.3390/cells10061547 – volume: 67 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0090 article-title: 3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase as the gatekeeper of plant aromatic natural product biosynthesis publication-title: Curr. Opin. Plant Biol. doi: 10.1016/j.pbi.2022.102219 – volume: 4 year: 2020 ident: 10.1016/j.tibs.2025.07.008_bb0470 article-title: Role of cytosolic, tyrosine-insensitive prephenate dehydrogenase in Medicago truncatula publication-title: Plant Direct. doi: 10.1002/pld3.218 – volume: 9 year: 2014 ident: 10.1016/j.tibs.2025.07.008_bb0060 article-title: How do haloarchaea synthesize aromatic amino acids? publication-title: PLoS One doi: 10.1371/journal.pone.0107475 – volume: 18 start-page: 1285 year: 2019 ident: 10.1016/j.tibs.2025.07.008_bb0725 article-title: Unraveling hidden components of the chloroplast envelope proteome: opportunities and limits of better MS sensitivity publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.RA118.000988 – volume: 132 start-page: 603 year: 2005 ident: 10.1016/j.tibs.2025.07.008_bb0275 article-title: Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis publication-title: Development doi: 10.1242/dev.01595 – volume: 253 start-page: 3 year: 2020 ident: 10.1016/j.tibs.2025.07.008_bb0715 article-title: Dehydroquinate dehydratase/shikimate dehydrogenases involved in gallate biosynthesis of the aluminum-tolerant tree species Eucalyptus camaldulensis publication-title: Planta doi: 10.1007/s00425-020-03516-w – volume: 63 start-page: 869 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0225 article-title: ATTED-II v11: a plant gene coexpression database using a sample balancing technique by subagging of principal components publication-title: Plant Cell Physiol. doi: 10.1093/pcp/pcac041 – volume: 8 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0115 article-title: Point mutations that boost aromatic amino acid production and CO2 assimilation in plants publication-title: Sci. Adv. doi: 10.1126/sciadv.abo3416 – volume: 269 start-page: 4753 year: 2002 ident: 10.1016/j.tibs.2025.07.008_bb0390 article-title: Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana publication-title: Eur. J. Biochem. doi: 10.1046/j.1432-1033.2002.03172.x – volume: 15 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0195 article-title: Engineering sorghum for higher 4-hydroxybenzoic acid content publication-title: Metab. Eng. Commun. doi: 10.1016/j.mec.2022.e00207 – volume: 202 year: 2020 ident: 10.1016/j.tibs.2025.07.008_bb0230 article-title: Structural and biochemical analyses reveal that chlorogenic acid inhibits the shikimate pathway publication-title: J. Bacteriol. doi: 10.1128/JB.00248-20 – volume: 14 year: 2023 ident: 10.1016/j.tibs.2025.07.008_bb0430 article-title: Arogenate dehydratases: unique roles in light-directed development during the seed-to-seedling transition in Arabidopsis thaliana publication-title: Front. Plant Sci. doi: 10.3389/fpls.2023.1220732 – volume: 50 start-page: 473 year: 1999 ident: 10.1016/j.tibs.2025.07.008_bb0035 article-title: The shikimate pathway publication-title: Annu. Rev. Plant Physiol. Plant Mol. Biol. doi: 10.1146/annurev.arplant.50.1.473 – volume: 379 year: 2024 ident: 10.1016/j.tibs.2025.07.008_bb0045 article-title: Evolution of aromatic amino acid metabolism in plants: a key driving force behind plant chemical diversity in aromatic natural products publication-title: Philos. Trans. R. Soc. B, Biol. Sci. doi: 10.1098/rstb.2023.0352 – volume: 172 start-page: 1612 year: 2016 ident: 10.1016/j.tibs.2025.07.008_bb0600 article-title: Primary metabolism during biosynthesis of secondary wall polymers of protoxylem vessel elements publication-title: Plant Physiol. doi: 10.1104/pp.16.01230 – volume: 11 start-page: 52 year: 2015 ident: 10.1016/j.tibs.2025.07.008_bb0325 article-title: Non-plastidic, tyrosine-insensitive prephenate dehydrogenases from legumes publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.1693 – volume: 285 start-page: 30567 year: 2010 ident: 10.1016/j.tibs.2025.07.008_bb0160 article-title: Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.111856 – volume: 64 start-page: 727 year: 1979 ident: 10.1016/j.tibs.2025.07.008_bb0460 article-title: Enzymology of L-tyrosine biosynthesis in mung bean (Vigna radiata [L.] Wilczek) publication-title: Plant Physiol. doi: 10.1104/pp.64.5.727 – volume: 92 start-page: 939 year: 2017 ident: 10.1016/j.tibs.2025.07.008_bb0655 article-title: Multifaceted plant responses to circumvent Phe hyperaccumulation by downregulation of flux through the shikimate pathway and by vacuolar Phe sequestration publication-title: Plant J. doi: 10.1111/tpj.13730 – volume: 25 start-page: 670 year: 2020 ident: 10.1016/j.tibs.2025.07.008_bb0075 article-title: Aromatic amino acids: a complex network ripe for future exploration publication-title: Trends Plant Sci. doi: 10.1016/j.tplants.2020.02.005 – volume: 107 start-page: 1620 year: 2019 ident: 10.1016/j.tibs.2025.07.008_bb0465 article-title: Macroevolutionary patterns in overexpression of tyrosine: an anti-herbivore defence in a speciose tropical tree genus, Inga (Fabaceae) publication-title: J. Ecol. doi: 10.1111/1365-2745.13208 – volume: 109 start-page: 844 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0445 article-title: Two independently evolved natural mutations additively deregulate TyrA enzymes and boost tyrosine production inplanta publication-title: Plant J. doi: 10.1111/tpj.15597 – volume: 3 start-page: 956 year: 2010 ident: 10.1016/j.tibs.2025.07.008_bb0010 article-title: New insights into the shikimate and aromatic amino acids biosynthesis pathways in plants publication-title: Mol. Plant doi: 10.1093/mp/ssq048 – volume: 41 start-page: 604 year: 2024 ident: 10.1016/j.tibs.2025.07.008_bb0070 article-title: The shikimate pathway: gateway to metabolic diversity publication-title: Nat. Prod. Rep. doi: 10.1039/D3NP00037K – volume: 81 start-page: 895 year: 2015 ident: 10.1016/j.tibs.2025.07.008_bb0575 article-title: ENO2 activity is required for the development and reproductive success of plants, and is feedback-repressed by AtMBP-1 publication-title: Plant J. doi: 10.1111/tpj.12775 – volume: 43 start-page: 7618 year: 2004 ident: 10.1016/j.tibs.2025.07.008_bb0055 article-title: L-aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii publication-title: Biochemistry doi: 10.1021/bi0495127 – volume: 9 start-page: 1461 year: 2018 ident: 10.1016/j.tibs.2025.07.008_bb0560 article-title: The xylulose 5-phosphate/phosphate translocator supports triose phosphate, but not phosphoenolpyruvate transport across the inner envelope membrane of plastids in Arabidopsis thaliana mutant plants publication-title: Front. Plant Sci. doi: 10.3389/fpls.2018.01461 – volume: 289 start-page: 28619 year: 2014 ident: 10.1016/j.tibs.2025.07.008_bb0335 article-title: Structural evolution of differential amino acid effector regulation in plant chorismate mutases publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.591123 – volume: 584 start-page: 4357 year: 2010 ident: 10.1016/j.tibs.2025.07.008_bb0365 article-title: Identification of a plant gene encoding glutamate/aspartate-prephenate aminotransferase: the last homeless enzyme of aromatic amino acids biosynthesis publication-title: FEBS Lett. doi: 10.1016/j.febslet.2010.09.037 – volume: 185 start-page: 649 year: 2010 ident: 10.1016/j.tibs.2025.07.008_bb0570 article-title: Plastidial glycolysis in developing Arabidopsis embryos publication-title: New Phytol. doi: 10.1111/j.1469-8137.2009.03113.x – volume: 72 start-page: 185 year: 2021 ident: 10.1016/j.tibs.2025.07.008_bb0040 article-title: Evolutionary history of plant metabolism publication-title: Annu. Rev. Plant Biol. doi: 10.1146/annurev-arplant-080620-031054 – volume: 13 start-page: 1029 year: 2017 ident: 10.1016/j.tibs.2025.07.008_bb0330 article-title: Molecular basis of the evolution of alternative tyrosine biosynthetic routes in plants publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.2414 – volume: 7 start-page: 19 year: 2011 ident: 10.1016/j.tibs.2025.07.008_bb0360 article-title: Prephenate aminotransferase directs plant phenylalanine biosynthesis via arogenate publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.485 – volume: 156 start-page: 233 year: 1982 ident: 10.1016/j.tibs.2025.07.008_bb0395 article-title: L-tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes publication-title: Planta doi: 10.1007/BF00393730 – volume: 13 start-page: 125 year: 2015 ident: 10.1016/j.tibs.2025.07.008_bb0205 article-title: Enhanced formation of aromatic amino acids increases fragrance without affecting flower longevity or pigmentation in Petunia × hybrida publication-title: Plant Biotechnol. J. doi: 10.1111/pbi.12253 – volume: 7 start-page: 907 year: 1995 ident: 10.1016/j.tibs.2025.07.008_bb0085 article-title: The shikimate pathway: early steps in the biosynthesis of aromatic compounds publication-title: Plant Cell doi: 10.2307/3870046 – volume: 299 year: 2023 ident: 10.1016/j.tibs.2025.07.008_bb0475 article-title: Mass spectrometry imaging-based assays for aminotransferase activity reveal a broad substrate spectrum for a previously uncharacterized enzyme publication-title: J. Biol. Chem. doi: 10.1016/j.jbc.2023.102939 – volume: 10 start-page: 10846 year: 2020 ident: 10.1016/j.tibs.2025.07.008_bb0295 article-title: Suppression of chorismate synthase, which is localized in chloroplasts and peroxisomes, results in abnormal flower development and anthocyanin reduction in petunia publication-title: Sci. Rep. doi: 10.1038/s41598-020-67671-6 – volume: 6 start-page: 8142 year: 2015 ident: 10.1016/j.tibs.2025.07.008_bb0315 article-title: Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network publication-title: Nat. Commun. doi: 10.1038/ncomms9142 – volume: 69 start-page: 417 year: 2018 ident: 10.1016/j.tibs.2025.07.008_bb0500 article-title: Essential roles of local auxin biosynthesis in plant development and in adaptation to environmental changes publication-title: Annu. Rev. Plant Biol. doi: 10.1146/annurev-arplant-042817-040226 – volume: 132 start-page: 16 year: 2016 ident: 10.1016/j.tibs.2025.07.008_bb0480 article-title: Biochemical properties and subcellular localization of tyrosine aminotransferases in Arabidopsis thaliana publication-title: Phytochemistry doi: 10.1016/j.phytochem.2016.09.007 – volume: 61 start-page: 2229 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0155 article-title: Role of half-of-sites reactivity and inter-subunit communications in DAHP synthase catalysis and regulation publication-title: Biochemistry doi: 10.1021/acs.biochem.2c00465 – volume: 1847 start-page: 915 year: 2015 ident: 10.1016/j.tibs.2025.07.008_bb0135 article-title: Organization, function and substrates of the essential Clp protease system in plastids publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbabio.2014.11.012 – volume: 10 year: 2024 ident: 10.1016/j.tibs.2025.07.008_bb0170 article-title: The cytosolic aminotransferase VAS1 coordinates aromatic amino acid biosynthesis and metabolism publication-title: Sci. Adv. – volume: 10 start-page: 545 year: 2019 ident: 10.1016/j.tibs.2025.07.008_bb0240 article-title: Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms publication-title: Nat. Commun. doi: 10.1038/s41467-019-08476-8 – volume: 110 start-page: 529 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0265 article-title: Direct regulation of shikimate, early phenylpropanoid, and stilbenoid pathways by Subgroup 2 R2R3-MYBs in grapevine publication-title: Plant J. doi: 10.1111/tpj.15686 – volume: 476 start-page: 2939 year: 2019 ident: 10.1016/j.tibs.2025.07.008_bb0605 article-title: Biochemical characterization of phosphoenolpyruvate carboxykinases from Arabidopsis thaliana publication-title: Biochem. J. doi: 10.1042/BCJ20190523 – volume: 3 start-page: 2 year: 2010 ident: 10.1016/j.tibs.2025.07.008_bb0025 article-title: Phenylpropanoid biosynthesis publication-title: Mol. Plant doi: 10.1093/mp/ssp106 – volume: 68 start-page: 292 year: 1981 ident: 10.1016/j.tibs.2025.07.008_bb0525 article-title: Amino acid synthesis in photosynthesizing spinach cells: effects of ammonia on pool sizes and rates of labeling from CO2 publication-title: Plant Physiol. doi: 10.1104/pp.68.2.292 – volume: 14 start-page: 7242 year: 2023 ident: 10.1016/j.tibs.2025.07.008_bb0120 article-title: Coordinated regulation of the entry and exit steps of aromatic amino acid biosynthesis supports the dual lignin pathway in grasses publication-title: Nat. Commun. doi: 10.1038/s41467-023-42587-7 – volume: 474 start-page: 3705 year: 2017 ident: 10.1016/j.tibs.2025.07.008_bb0345 article-title: Evolution of allosteric regulation in chorismate mutases from early plants publication-title: Biochem. J. doi: 10.1042/BCJ20170549 – volume: 153 start-page: 1526 year: 2010 ident: 10.1016/j.tibs.2025.07.008_bb0630 article-title: Functional analysis of the arabidopsis PAL gene family in plant growth, development, and Response to environmental stress publication-title: Plant Physiol. doi: 10.1104/pp.110.157370 – volume: 9 start-page: 1609 year: 2016 ident: 10.1016/j.tibs.2025.07.008_bb0410 article-title: Arogenate dehydratase isoforms differentially regulate anthocyanin biosynthesis in Arabidopsis thaliana publication-title: Mol. Plant doi: 10.1016/j.molp.2016.09.010 – volume: 20 start-page: 1316 year: 2008 ident: 10.1016/j.tibs.2025.07.008_bb0625 article-title: Mutation of a rice gene encoding a phenylalanine biosynthetic enzyme results in accumulation of phenylalanine and tryptophan publication-title: Plant Cell doi: 10.1105/tpc.107.057455 – volume: 83 start-page: 7231 year: 1986 ident: 10.1016/j.tibs.2025.07.008_bb0385 article-title: Chloroplasts of higher plants synthesize L-phenylalanine via L-arogenate publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.83.19.7231 – volume: 188 start-page: 134 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0400 article-title: Deregulation of phenylalanine biosynthesis evolved with the emergence of vascular plants publication-title: Plant Physiol. doi: 10.1093/plphys/kiab454 – volume: 13 start-page: 929 year: 2024 ident: 10.1016/j.tibs.2025.07.008_bb0340 article-title: Properties and functional analysis of two chorismate mutases from maritime pine publication-title: Cells doi: 10.3390/cells13110929 – volume: 17 start-page: 1612 year: 2005 ident: 10.1016/j.tibs.2025.07.008_bb0425 article-title: ODORANT1 regulates fragrance biosynthesis in petunia flowers publication-title: Plant Cell doi: 10.1105/tpc.104.028837 – volume: 65 start-page: 495 year: 2014 ident: 10.1016/j.tibs.2025.07.008_bb0100 article-title: Opposite action of R2R3-MYBs from different subgroups on key genes of the shikimate and monolignol pathways in spruce publication-title: J. Exp. Bot. doi: 10.1093/jxb/ert398 – volume: 238 start-page: 155 year: 2023 ident: 10.1016/j.tibs.2025.07.008_bb0285 article-title: The female germ unit is essential for pollen tube funicular guidance in Arabidopsis thaliana publication-title: New Phytol. doi: 10.1111/nph.18686 – volume: 16 start-page: 850 year: 2020 ident: 10.1016/j.tibs.2025.07.008_bb0505 article-title: Modulation of auxin formation by the cytosolic phenylalanine biosynthetic pathway publication-title: Nat. Chem. Biol. doi: 10.1038/s41589-020-0519-8 – volume: 64 start-page: 4441 year: 2013 ident: 10.1016/j.tibs.2025.07.008_bb0190 article-title: Tomato fruits expressing a bacterial feedback-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway possess enhanced levels of multiple specialized metabolites and upgraded aroma publication-title: J. Exp. Bot. doi: 10.1093/jxb/ert250 – volume: 298 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0435 article-title: Proteomics, phylogenetics, and coexpression analyses indicate novel interactions in the plastid CLP chaperone-protease system publication-title: J. Biol. Chem. doi: 10.1016/j.jbc.2022.101609 – year: 2025 ident: 10.1016/j.tibs.2025.07.008_bb0270 article-title: MYC2 and MYC3 orchestrate pith lignification to defend Nicotiana attenuata stems against a stem-boring weevil publication-title: New Phytol. doi: 10.1111/nph.70325 – volume: 87 start-page: 215 year: 2016 ident: 10.1016/j.tibs.2025.07.008_bb0380 article-title: Identification of a small protein domain present in all plant lineages that confers high prephenate dehydratase activity publication-title: Plant J. doi: 10.1111/tpj.13195 – volume: 25 start-page: 2276 year: 2013 ident: 10.1016/j.tibs.2025.07.008_bb0130 article-title: ClpS1 is a conserved substrate selector for the chloroplast Clp protease system in Arabidopsis publication-title: Plant Cell doi: 10.1105/tpc.113.112557 – volume: 9 year: 2022 ident: 10.1016/j.tibs.2025.07.008_bb0080 article-title: Revisiting the dual pathway hypothesis of Chorismate production in plants publication-title: Hortic. Res. doi: 10.1093/hr/uhac052 – volume: 44 start-page: 337 year: 2010 ident: 10.1016/j.tibs.2025.07.008_bb0020 article-title: The genetics of lignin biosynthesis: connecting genotype to phenotype publication-title: Annu. Rev. Genet. doi: 10.1146/annurev-genet-102209-163508 – volume: 63 start-page: 73 year: 2012 ident: 10.1016/j.tibs.2025.07.008_bb0005 article-title: The shikimate pathway and aromatic amino acid biosynthesis in plants publication-title: Annu. Rev. Plant Biol. doi: 10.1146/annurev-arplant-042811-105439 – volume: 23 start-page: 421 year: 2024 ident: 10.1016/j.tibs.2025.07.008_bb0050 article-title: Revisiting the shikimate pathway and highlighting their enzyme inhibitors publication-title: Phytochem. Rev. doi: 10.1007/s11101-023-09889-6 – volume: 75 start-page: 555 year: 2011 ident: 10.1016/j.tibs.2025.07.008_bb0700 article-title: Mechanism of gallic acid biosynthesis in bacteria (Escherichia coli) and walnut (Juglans regia) publication-title: Plant Mol. Biol. doi: 10.1007/s11103-011-9739-3 – volume: 22 start-page: 832 year: 2010 ident: 10.1016/j.tibs.2025.07.008_bb0305 article-title: RNAi suppression of arogenate dehydratase 1 reveals that phenylalanine is synthesized predominantly via the arogenate pathway in petunia petals publication-title: Plant Cell doi: 10.1105/tpc.109.073247 |
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| Snippet | Plants commit large amounts of carbon and energy to the biosynthesis of aromatic amino acids (AAAs), because these molecules are precursors to a multitude of... The shikimate and aromatic amino acid (AAA) biosynthetic pathways are crucial for the production of L-phenylalanine (Phe), L-tyrosine (Tyr), and L-tryptophan... |
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| SubjectTerms | aromatic amino acids phenylalanine phenylpropanoids shikimate pathway tyrosine |
| Title | The multilayered regulation of aromatic amino acid biosynthesis in plants |
| URI | https://dx.doi.org/10.1016/j.tibs.2025.07.008 https://www.ncbi.nlm.nih.gov/pubmed/40866156 https://www.proquest.com/docview/3246405230 |
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