Application of Liposome Encapsulation Drug in Inhibiting Ferroptosis and Reducing Radiation Damage During Radiotherapy

To alleviate the side effects of radiotherapy, amifostine, as the first FDA-approved radiation protectant, can be used to eliminate free radicals and regulate redox reactions. However, its application is limited by toxic side effects. Liposomes, as drug carriers, can efficiently encapsulate drugs an...

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Bibliographic Details
Published in:Nano biomedicine and engineering Vol. 17; no. 4; pp. 517 - 528
Main Authors: Zhou, Yongkang, Ding, Xuan, Guo, Genwu, Zhuang, Yuan, Chen, Yixing, Zhang, Fuquan, He, Jian, Gao, Yunan
Format: Journal Article
Language:English
Published: Tsinghua University Press 01.12.2025
Subjects:
amifostine
ferroptosis
liposome
radiation damage
ISSN:2097-3837, 2150-5578
Online Access:Get full text
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Summary:To alleviate the side effects of radiotherapy, amifostine, as the first FDA-approved radiation protectant, can be used to eliminate free radicals and regulate redox reactions. However, its application is limited by toxic side effects. Liposomes, as drug carriers, can efficiently encapsulate drugs and increase their concentration in tumor sites through passive targeting, reducing damage to normal tissues. Liposomes encapsulating antioxidant drugs can significantly inhibit ferroptosis caused by radiotherapy and alleviate lung and intestinal damage. Therefore, we prepared a novel nanomedicine with less toxic and highly effective radiation protectants based on liposome-encapsulated amifostine. By precisely regulating the ferroptosis pathway, it shows good radiation protection effects, providing a new strategy for the treatment of radiation pneumonitis and intestinal injury, and is expected to improve the quality of life and treatment outcomes of patients.
ISSN:2097-3837
2150-5578
DOI:10.26599/NBE.2025.9290124