Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction

The interrupted Fischer indole synthesis of arylhydrazines and biocatalytically generated chiral bicyclic imines selectively affords either tetracyclic pyrroloindolines or tricyclic tryptamine analogues depending on the reaction conditions. We demonstrate that the reaction is compatible with a varie...

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Bibliographic Details
Published in:	Angewandte Chemie Vol. 127; no. 47; pp. 14339 - 14342
Main Authors:	de Graaff, Corien, Bensch, Lisa, Boersma, Sjoerd J., Cioc, Răzvan C., van Lint, Matthijs J., Janssen, Elwin, Turner, Nicholas J., Orru, Romano V. A., Ruijter, Eelco
Format:	Journal Article
Language:	English German
Published:	Weinheim WILEY‐VCH Verlag 16.11.2015 Wiley Subscription Services, Inc
Subjects:	Asymmetric synthesis Asymmetrische Synthesen Asymmetry Biologisch aktive Verbindungen Capsaicin receptors Cascade chemical reactions Chemistry Cholinesterase Cholinesterase inhibitors Constraints Derivatives Functional groups Imines Indoles Inhibitors Ion channels Reaction mechanisms Reaktionskaskaden Serotonin Stoichiometry Synthesemethoden Synthesis (chemistry) Tryptamine Tryptamines
ISSN:	0044-8249, 1521-3757
Online Access:	Get full text
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