Medication-Related Osteonecrosis of the Jaw: a Brief Review, Treatment and Practical Guidelines for Dentists

Osteonecrosis of the jaws is a complication after treatment with antiresorptive drugs. Bisphosphonates (BPs) are widely used to treat conditions with bone metastases of malignant tumors such as multiple myeloma, breast cancer, prostatic cancer, as well as hypercalcemia of malignancy, osteoporosis, P...

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Vydané v:Journal of Interdisciplinary Medicine Ročník 2; číslo 2; s. 117 - 121
Hlavní autori: Albu-Stan, Ioana-Aurița, Albu, Daniel-Emil, Cerghizan, Diana, Eremie, Lia Yero, Jánosi, Kinga, Baloș, Monica, Copotoiu, Constantin
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Târgu Mureș Sciendo 01.06.2017
De Gruyter Brill Sp. z o.o., Paradigm Publishing Services
Predmet:
antiresorptive drugs
bisphosphonates
Disease
Necrosis
osteonecrosis
Osteoporosis
quality of life
surgery
ISSN:2501-8132, 2501-5974, 2501-8132
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Abstract Osteonecrosis of the jaws is a complication after treatment with antiresorptive drugs. Bisphosphonates (BPs) are widely used to treat conditions with bone metastases of malignant tumors such as multiple myeloma, breast cancer, prostatic cancer, as well as hypercalcemia of malignancy, osteoporosis, Paget’s disease, and osteogenesis imperfecta. Denosumab is an antiresorptive agent that is used for the treatment of osteoporosis or metastatic bone diseases. These antiresorptive agents improve the quality of life of patients by increasing strength and bone mineral density, and reducing the risk of bone fractures. More than a decade had passed since the first publication of this pathology, and the occurrence of the disease, its pathophysiology, and proper treatment methods are still not fully elucidated. Prevention is critical in medication-related osteonecrosis of the jaw, because the treatment is difficult, and there are no universally accepted treatment protocols. There is an accepted approach of palliation of symptoms and controlling the associated infections. Treatment may follow one of three procedures: conservative management of pain, conservative or extensive (segmental) surgery, depending on the disease stage.
AbstractList Osteonecrosis of the jaws is a complication after treatment with antiresorptive drugs. Bisphosphonates (BPs) are widely used to treat conditions with bone metastases of malignant tumors such as multiple myeloma, breast cancer, prostatic cancer, as well as hypercalcemia of malignancy, osteoporosis, Paget’s disease, and osteogenesis imperfecta. Denosumab is an antiresorptive agent that is used for the treatment of osteoporosis or metastatic bone diseases. These antiresorptive agents improve the quality of life of patients by increasing strength and bone mineral density, and reducing the risk of bone fractures. More than a decade had passed since the first publication of this pathology, and the occurrence of the disease, its pathophysiology, and proper treatment methods are still not fully elucidated. Prevention is critical in medication-related osteonecrosis of the jaw, because the treatment is difficult, and there are no universally accepted treatment protocols. There is an accepted approach of palliation of symptoms and controlling the associated infections. Treatment may follow one of three procedures: conservative management of pain, conservative or extensive (segmental) surgery, depending on the disease stage.
Author Cerghizan, Diana
Baloș, Monica
Albu-Stan, Ioana-Aurița
Albu, Daniel-Emil
Eremie, Lia Yero
Copotoiu, Constantin
Jánosi, Kinga
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SubjectTerms antiresorptive drugs
bisphosphonates
Disease
Necrosis
osteonecrosis
Osteoporosis
quality of life
surgery
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