Early Relative Hypotension Below Noninvasive Cerebral Oximetry-Derived Optimal Blood Pressure Thresholds in Aneurysmal Subarachnoid Hemorrhage: A Pilot Study

Impairment in cerebral autoregulation (CA) after aneurysmal subarachnoid hemorrhage (aSAH) is associated with delayed cerebral ischemia (DCI) and poor outcomes. We assessed: 1) feasibility of defining CA-based optimal mean arterial pressure (MAP Opt ) thresholds using noninvasive cerebral oximetry a...

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Published in:Critical care medicine Vol. 53; no. 11; p. e2323
Main Authors: Shah, Vishank A, Humayun, Mariyam, Radzik, Batya, Healy, Ryan, Palmisano, Caitlin, Anderson-White, Mirinda, Calvillo, Eusebia, Geocadin, Romergryko, Brown, 4th, Charles, Hogue, Charles, Ziai, Wendy, Cho, Sung-Min, Suarez, Jose I, Rivera-Lara, Lucia
Format: Journal Article
Language:English
Published: United States 01.11.2025
Subjects:
Aged
Arterial Pressure - physiology
Brain Ischemia - etiology
Cerebrovascular Circulation - physiology
Female
Homeostasis - physiology
Humans
Hypotension - etiology
Hypotension - physiopathology
Male
Middle Aged
Oximetry - methods
Pilot Projects
Prospective Studies
Subarachnoid Hemorrhage - complications
Subarachnoid Hemorrhage - physiopathology
optimal blood pressure
delayed cerebral ischemia
long-term outcomes
aneurysmal subarachnoid hemorrhage
noninvasive cerebral oximetry
early brain injury
ISSN:1530-0293, 1530-0293
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Summary:Impairment in cerebral autoregulation (CA) after aneurysmal subarachnoid hemorrhage (aSAH) is associated with delayed cerebral ischemia (DCI) and poor outcomes. We assessed: 1) feasibility of defining CA-based optimal mean arterial pressure (MAP Opt ) thresholds using noninvasive cerebral oximetry and 2) associations of relative hypotension below MAP Opt in the early brain injury (EBI) and pre-DCI phase with DCI and long-term outcomes after aSAH. Pilot observational study on a prospective cohort. Single-center Neuro-ICU. aSAH patients with altered consciousness. Continuous noninvasive cerebral oximetry neuromonitoring. Daily MAP Opt was defined as observed MAP (MAP Obs ) corresponding to lowest cerebral oximetry-derived autoregulation index. Outcomes included DCI and 1-year modified Rankin Scale (mRS). Mixed-effects linear regression assessed MAP Opt trajectories. Multivariable generalized estimating equation models assessed associations between daily %time below MAP Opt ± 5 mm Hg (MAP Opt range) and DCI and poor 1-year mRS (mRS 4-6). We included 118 daily MAP Opt measurements (118/128 epochs = 92.2% feasibility) estimated from 35 aSAH patients receiving cerebral oximetry monitoring for median duration of 4 days (interquartile range [IQR], 3-4 d), beginning on median of hospital day 2 (1-3). Median (IQR) age was 64 years (52-69 yr), World Federation of Neurological Surgeons grade 4 (2-5), and modified Fisher Scale 4 (3-4). DCI and poor 1-year outcome occurred in 15 (42.9%) and 20 (57.1%) patients, respectively. Patients that developed DCI had higher median MAP Opt (102.5 vs. 85 mm Hg; p = 0.03), upward trajectory of MAP Opt (β-coefficient = +19 mm Hg; p = 0.04 vs. +4 mm Hg; p = 0.56), and greater %time with MAP Obs below MAP Opt range (39.7% vs. 12.7%; p = 0.01) in the early phase. In covariate-adjusted models, %time below MAP Opt range was independently associated with DCI and poor 1-year mRS (adjusted odds ratio, 1.02; 95% CI, 1.002-1.03; p = 0.03). Defining individualized MAP Opt thresholds using noninvasive cerebral oximetry was feasible. Relative hypotension below oximetry-based MAP Opt in the EBI and pre-DCI phase (days~2-6) was associated with DCI and poor long-term functional outcome, supporting further exploration of individualized hemodynamic optimization in the early phase of aSAH.
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ISSN:1530-0293
1530-0293
DOI:10.1097/CCM.0000000000006826