Sequential V(A)/Q distributions in the normal rabbit by micropore membrane inlet mass spectrometry

We developed micropore membrane inlet mass spectrometer (MMIMS) probes to rapidly measure inert-gas partial pressures in small blood samples. The mass spectrometer output was linearly related to inert-gas partial pressure (r(2) of 0.996-1.000) and was nearly independent of large variations in inert-...

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Vydané v:Journal of applied physiology (1985) Ročník 89; číslo 5; s. 1699
Hlavní autori: Baumgardner, J E, Choi, I C, Vonk-Noordegraaf, A, Frasch, H F, Neufeld, G R, Marshall, B E
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.11.2000
Predmet:
Acetone - analysis
Anesthetics, Inhalation - analysis
Animals
Blood Gas Analysis - instrumentation
Blood Gas Analysis - methods
Enflurane - analysis
Ether - analysis
Female
Isoflurane - analogs & derivatives
Isoflurane - analysis
Krypton - analysis
Mass Spectrometry - instrumentation
Mass Spectrometry - methods
Membranes, Artificial
Noble Gases - analysis
Partial Pressure
Pulmonary Artery - physiology
Rabbits
Sensitivity and Specificity
Solubility
Sulfur Hexafluoride - analysis
Ventilation-Perfusion Ratio
ISSN:8750-7587
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Popis
Shrnutí:We developed micropore membrane inlet mass spectrometer (MMIMS) probes to rapidly measure inert-gas partial pressures in small blood samples. The mass spectrometer output was linearly related to inert-gas partial pressure (r(2) of 0.996-1.000) and was nearly independent of large variations in inert-gas solubility in liquid samples. We infused six inert gases into five pentobarbital-anesthetized New Zealand rabbits and used the MMIMS system to measure inert-gas partial pressures in systemic and pulmonary arterial blood and in mixed expired gas samples. The retention and excretion data were transformed into distributions of ventilation-to-perfusion ratios (V(A)/Q) with the use of linear regression techniques. Distributions of V(A)/Q were unimodal and broad, consistent with prior reports in the normal rabbit. Total blood sample volume for each VA/Q distribution was 4 ml, and analysis time was 8 min. MMIMS provides a convenient method to perform the multiple inert-gas elimination technique rapidly and with small blood sample volumes.
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SourceType-Scholarly Journals-1
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ISSN:8750-7587
DOI:10.1152/jappl.2000.89.5.1699