In Vivo and in Vitro Selection of Mitogen Responsive Lymphocytes in Patients with Chronic Lymphocytic Leukemia

The in vitro mitogen response of blood lymphoid cells from patients with chronic lymphocytic leukemia was observed to be low compared to lymphocytes from healthy subjects. However, highly responsive cells could be separated from the blood of such patients by a buoyant density centrifugation techniqu...

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Bibliographic Details
Published in:Acta radiologica. Therapy physics biology Vol. 15; no. 1; pp. 23 - 32
Main Authors: Blomgren, H., Jondal, M., Johansson, B.
Format: Journal Article
Language:English
Published: Sweden 1976
Subjects:
Adult
Aged
Cell Separation - methods
Chlorambucil - therapeutic use
Concanavalin A - pharmacology
Cyclophosphamide - therapeutic use
Female
Humans
Immunologic Techniques
In Vitro Techniques
Lectins - pharmacology
Leukemia, Lymphoid - drug therapy
Leukemia, Lymphoid - immunology
Leukemia, Lymphoid - radiotherapy
Leukocyte Count
Lymphoma - drug therapy
Lymphoma - immunology
Lymphoma - radiotherapy
Male
Middle Aged
Spleen - radiation effects
T-Lymphocytes - immunology
T-Lymphocytes - radiation effects
ISSN:0567-8064
Online Access:Get full text
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Summary:The in vitro mitogen response of blood lymphoid cells from patients with chronic lymphocytic leukemia was observed to be low compared to lymphocytes from healthy subjects. However, highly responsive cells could be separated from the blood of such patients by a buoyant density centrifugation technique and such reactive cells were found to be enriched by treating the patients with chemotherapy or splenic irradiation.
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ISSN:0567-8064
DOI:10.3109/02841867609132705